6bzs - Revision history

OCA at 14:53, 4 October 2023

OCA — Wed, 04 Oct 2023 14:53:42 GMT

←Older revision		Revision as of 14:53, 4 October 2023
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	<StructureSection load='6bzs' size='340' side='right'caption='[[6bzs]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='6bzs' size='340' side='right'caption='[[6bzs]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bzs]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BZS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bzs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BZS FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2999046Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[6bzr\|6bzr]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">ABCC6, ARA, MRP6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bzs OCA], [https://pdbe.org/6bzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bzs RCSB], [https://www.ebi.ac.uk/pdbsum/6bzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bzs ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bzs OCA], [~~http~~://pdbe.org/6bzs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bzs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bzs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bzs ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MRP6_HUMAN MRP6_HUMAN]] Generalized arterial calcification of infancy;Pseudoxanthoma elasticum. The disease is caused by mutations affecting the gene represented in this entry. Homozygous or compound heterozygous ABCC6 mutations have been found in the overwhelming majority of cases. Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/MRP6_HUMAN MRP6_HUMAN] Generalized arterial calcification of infancy;Pseudoxanthoma elasticum. The disease is caused by mutations affecting the gene represented in this entry. Homozygous or compound heterozygous ABCC6 mutations have been found in the overwhelming majority of cases. Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MRP6_HUMAN MRP6_HUMAN]] Isoform 1: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).<ref>PMID:11880368</ref> Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases.<ref>PMID:23912081</ref>	+	[https://www.uniprot.org/uniprot/MRP6_HUMAN MRP6_HUMAN] Isoform 1: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).<ref>PMID:11880368</ref> Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases.<ref>PMID:23912081</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Thibodeau~~, P H~~]]	+	[[Category: Thibodeau PH]]
-	[[Category: Zheng, A]]	+	[[Category: Zheng A]]
-	~~[[Category: Abcc6]]~~	+
-	~~[[Category: Apo state]]~~	+
-	~~[[Category: Atp-binding cassette transporter c6]]~~	+
-	~~[[Category: Nbd1]]~~	+
-	~~[[Category: Nucleotide binding domain 1]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 09:26, 18 December 2019

OCA — Wed, 18 Dec 2019 09:26:42 GMT

←Older revision		Revision as of 09:26, 18 December 2019
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	==Human ABCC6 NBD1 in Apo state==		==Human ABCC6 NBD1 in Apo state==
-	<StructureSection load='6bzs' size='340' side='right' caption='[[6bzs]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='6bzs' size='340' side='right'caption='[[6bzs]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6bzs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BZS FirstGlance]. <br>		<table><tr><td colspan='2'>[[6bzs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BZS FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Thibodeau, P H]]		[[Category: Thibodeau, P H]]
	[[Category: Zheng, A]]		[[Category: Zheng, A]]

OCA at 20:16, 19 September 2018

OCA — Wed, 19 Sep 2018 20:16:29 GMT

←Older revision		Revision as of 20:16, 19 September 2018
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	<StructureSection load='6bzs' size='340' side='right' caption='[[6bzs]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='6bzs' size='340' side='right' caption='[[6bzs]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bzs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BZS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bzs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BZS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6bzr\|6bzr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6bzr\|6bzr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABCC6, ARA, MRP6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bzs OCA], [http://pdbe.org/6bzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bzs RCSB], [http://www.ebi.ac.uk/pdbsum/6bzs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bzs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bzs OCA], [http://pdbe.org/6bzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bzs RCSB], [http://www.ebi.ac.uk/pdbsum/6bzs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bzs ProSAT]</span></td></tr>
	</table>		</table>
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MRP6_HUMAN MRP6_HUMAN]] Isoform 1: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).<ref>PMID:11880368</ref> Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases.<ref>PMID:23912081</ref>		[[http://www.uniprot.org/uniprot/MRP6_HUMAN MRP6_HUMAN]] Isoform 1: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).<ref>PMID:11880368</ref> Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases.<ref>PMID:23912081</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mutations in ATP-binding cassette subfamily C member 6 (ABCC6) transporter are associated with pseudoxanthoma elasticum (PXE), a disease resulting in ectopic mineralization and affecting multiple tissues. A growing number of mutations have been identified in individuals with PXE. For most of these variants, no mechanistic information is available regarding their role in normal and pathophysiologies. To assess how PXE-associated mutations alter ABCC6 biosynthesis and structure, we biophysically and biochemically evaluated the N-terminal nucleotide-binding domain of ABCC6. A high-resolution X-ray structure of nucleotide-binding domain 1 (NBD1) of human ABCC6 was obtained at 2.3 A that provided a template on which to evaluate PXE-causing mutations. Biochemical analysis of mutations in this domain indicated that multiple PXE-causing mutations altered its structural properties. Analyses of the full-length protein revealed a strong correlation between the alterations in NBD properties and the processing and expression of ABCC6. These results suggest that a significant fraction of PXE-associated mutations located in NBD1 causes changes in its structural properties and that these mutation-induced alterations directly affect the maturation of the full-length ABCC6 protein.
		+
		+	Structural analysis reveals pathomechanisms associated with pseudoxanthoma elasticum-causing mutations in the ABCC6 transporter.,Ran Y, Zheng A, Thibodeau PH J Biol Chem. 2018 Aug 28. pii: RA118.004806. doi: 10.1074/jbc.RA118.004806. PMID:30154241<ref>PMID:30154241</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6bzs" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Thibodeau, P H]]		[[Category: Thibodeau, P H]]
	[[Category: Zheng, A]]		[[Category: Zheng, A]]

OCA at 10:05, 5 September 2018

OCA — Wed, 05 Sep 2018 10:05:08 GMT

←Older revision		Revision as of 10:05, 5 September 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The entry ~~6bzs~~ is ~~ON HOLD~~ ~~until Dec 26 2019~~	+	==Human ABCC6 NBD1 in Apo state==
-		+	<StructureSection load='6bzs' size='340' side='right' caption='[[6bzs]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6bzs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BZS FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6bzr\|6bzr]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bzs OCA], [http://pdbe.org/6bzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bzs RCSB], [http://www.ebi.ac.uk/pdbsum/6bzs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bzs ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/MRP6_HUMAN MRP6_HUMAN]] Generalized arterial calcification of infancy;Pseudoxanthoma elasticum. The disease is caused by mutations affecting the gene represented in this entry. Homozygous or compound heterozygous ABCC6 mutations have been found in the overwhelming majority of cases. Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MRP6_HUMAN MRP6_HUMAN]] Isoform 1: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).<ref>PMID:11880368</ref> Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases.<ref>PMID:23912081</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Thibodeau, P H]]
		+	[[Category: Zheng, A]]
		+	[[Category: Abcc6]]
		+	[[Category: Apo state]]
		+	[[Category: Atp-binding cassette transporter c6]]
		+	[[Category: Nbd1]]
		+	[[Category: Nucleotide binding domain 1]]
		+	[[Category: Transport protein]]

OCA at 04:36, 4 April 2018

OCA — Wed, 04 Apr 2018 04:36:25 GMT

←Older revision		Revision as of 04:36, 4 April 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bzs is ON HOLD	+	The entry 6bzs is ON HOLD until Dec 26 2019

	Authors:		Authors:

OCA at 05:04, 14 March 2018

OCA — Wed, 14 Mar 2018 05:04:03 GMT

←Older revision		Revision as of 05:04, 14 March 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bzs is ON HOLD ~~until Dec 26 2019~~	+	The entry 6bzs is ON HOLD

	Authors:		Authors:

OCA at 17:16, 24 January 2018

OCA — Wed, 24 Jan 2018 17:16:16 GMT

←Older revision		Revision as of 17:16, 24 January 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bzs is ON HOLD	+	The entry 6bzs is ON HOLD until Dec 26 2019

	Authors:		Authors:

OCA: Protected "6bzs" [edit=sysop:move=sysop]

OCA — Wed, 03 Jan 2018 04:55:51 GMT

Protected "6bzs" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:55, 3 January 2018

OCA: New page: '''Unreleased structure''' The entry 6bzs is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 03 Jan 2018 04:55:50 GMT

New page: '''Unreleased structure''' The entry 6bzs is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6bzs is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]