6bzv - Revision history

OCA at 07:06, 2 February 2022

OCA — Wed, 02 Feb 2022 07:06:17 GMT

←Older revision		Revision as of 07:06, 2 February 2022
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	<StructureSection load='6bzv' size='340' side='right'caption='[[6bzv]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='6bzv' size='340' side='right'caption='[[6bzv]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bzv]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BZV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bzv]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BZV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bzv OCA], [~~http~~://pdbe.org/6bzv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bzv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bzv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bzv ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bzv OCA], [https://pdbe.org/6bzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bzv RCSB], [https://www.ebi.ac.uk/pdbsum/6bzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bzv ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 6bzv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6bzv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
-	[[Category: ~~Alemn~~, F]]	+	[[Category: Aleman, F]]
	[[Category: Law, M]]		[[Category: Law, M]]
	[[Category: Tzarum, N]]		[[Category: Tzarum, N]]

OCA at 09:27, 18 December 2019

OCA — Wed, 18 Dec 2019 09:27:09 GMT

←Older revision		Revision as of 09:27, 18 December 2019
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	==Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the GL precursor of the broadly neutralizing antibody 19B3==		==Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the GL precursor of the broadly neutralizing antibody 19B3==
-	<StructureSection load='6bzv' size='340' side='right' caption='[[6bzv]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='6bzv' size='340' side='right'caption='[[6bzv]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6bzv]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BZV FirstGlance]. <br>		<table><tr><td colspan='2'>[[6bzv]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BZV FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Alemn, F]]		[[Category: Alemn, F]]

OCA at 06:11, 11 July 2018

OCA — Wed, 11 Jul 2018 06:11:55 GMT

←Older revision		Revision as of 06:11, 11 July 2018
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	<StructureSection load='6bzv' size='340' side='right' caption='[[6bzv]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='6bzv' size='340' side='right' caption='[[6bzv]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bzv]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BZV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bzv]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BZV FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bzv OCA], [http://pdbe.org/6bzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bzv RCSB], [http://www.ebi.ac.uk/pdbsum/6bzv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bzv ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bzv OCA], [http://pdbe.org/6bzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bzv RCSB], [http://www.ebi.ac.uk/pdbsum/6bzv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bzv ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Elicitation of broadly neutralizing antibodies (bnAbs) is a leading strategy in rational vaccine design against antigenically diverse pathogens. Here, we studied a panel of monoclonal antibodies (mAbs) from mice immunized with the hepatitis C virus (HCV) envelope glycoproteins E1E2. Six of the mAbs recognize the conserved E2 antigenic site 412-423 (AS412) and cross-neutralize diverse HCV genotypes. Immunogenetic and structural analysis revealed that the antibodies originated from two different germline (GL) precursors and bind AS412 in a beta-hairpin conformation. Intriguingly, the anti-HCV activity of one antibody lineage is associated with maturation of the light chain (LC), whereas the other lineage is dependent on heavy-chain (HC) maturation. Crystal structures of GL precursors of the LC-dependent lineage in complex with AS412 offer critical insights into the maturation process of bnAbs to HCV, providing a scientific foundation for utilizing the mouse model to study AS412-targeting vaccine candidates.
		+
		+	Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors.,Aleman F, Tzarum N, Kong L, Nagy K, Zhu J, Wilson IA, Law M Proc Natl Acad Sci U S A. 2018 Jun 28. pii: 1802378115. doi:, 10.1073/pnas.1802378115. PMID:29954862<ref>PMID:29954862</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6bzv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Alemn, F]]		[[Category: Alemn, F]]
	[[Category: Law, M]]		[[Category: Law, M]]

OCA at 05:49, 20 June 2018

OCA — Wed, 20 Jun 2018 05:49:42 GMT

←Older revision		Revision as of 05:49, 20 June 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6bzv is ~~ON HOLD until Paper Publication~~	+	==Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the GL precursor of the broadly neutralizing antibody 19B3==
-		+	<StructureSection load='6bzv' size='340' side='right' caption='[[6bzv]], [[Resolution\|resolution]] 2.65Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6bzv]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BZV FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bzv OCA], [http://pdbe.org/6bzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bzv RCSB], [http://www.ebi.ac.uk/pdbsum/6bzv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bzv ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Alemn, F]]
		+	[[Category: Law, M]]
		+	[[Category: Tzarum, N]]
		+	[[Category: Wilson, I A]]
		+	[[Category: Antibody]]
		+	[[Category: As412]]
		+	[[Category: Broadly neutralizing antibody]]
		+	[[Category: E2]]
		+	[[Category: Hepatitis c virus]]
		+	[[Category: Immune system]]
		+	[[Category: Rational vaccine design]]
		+	[[Category: Viral protein]]

OCA at 05:41, 17 January 2018

OCA — Wed, 17 Jan 2018 05:41:16 GMT

←Older revision		Revision as of 05:41, 17 January 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bzv is ON HOLD	+	The entry 6bzv is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6bzv" [edit=sysop:move=sysop]

OCA — Wed, 03 Jan 2018 04:55:58 GMT

Protected "6bzv" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:55, 3 January 2018

OCA: New page: '''Unreleased structure''' The entry 6bzv is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 03 Jan 2018 04:55:57 GMT

New page: '''Unreleased structure''' The entry 6bzv is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6bzv is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]