6c4g - Revision history

OCA at 14:55, 4 October 2023

OCA — Wed, 04 Oct 2023 14:55:54 GMT

←Older revision		Revision as of 14:55, 4 October 2023
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	<StructureSection load='6c4g' size='340' side='right'caption='[[6c4g]], [[Resolution\|resolution]] 2.39Å' scene=''>		<StructureSection load='6c4g' size='340' side='right'caption='[[6c4g]], [[Resolution\|resolution]] 2.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6c4g]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Haemamoeba_vivax Haemamoeba~~ vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6C4G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6c4g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C4G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EQG:benzyl+[(6S,7S,10S,13S,18Z)-18-amino-10-cyclohexyl-6-hydroxy-18-imino-7-(2-methylpropyl)-4,9,12-trioxo-1-phenyl-16-oxa-3,8,11,17-tetraazaoctadecan-13-yl]carbamate'>EQG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.39Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6c4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c4g OCA], [~~http~~://pdbe.org/6c4g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6c4g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6c4g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6c4g ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EQG:benzyl+[(6S,7S,10S,13S,18Z)-18-amino-10-cyclohexyl-6-hydroxy-18-imino-7-(2-methylpropyl)-4,9,12-trioxo-1-phenyl-16-oxa-3,8,11,17-tetraazaoctadecan-13-yl]carbamate'>EQG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c4g OCA], [https://pdbe.org/6c4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c4g RCSB], [https://www.ebi.ac.uk/pdbsum/6c4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c4g ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PLM5_PLAVS PLM5_PLAVS] During the asexual blood stage, plays an essential role in the export of several proteins into the host erythrocytes by cleaving the pentameric localization motif RxLxE/Q/D (termed Plasmodium export element (PEXEL)) located downstream of the N-terminal secretory signal sequence (PubMed:24983235). Specifically, cleaves after the leucine residue in the RxLxE/Q/D (or RxLxxE) motif of exported proteins including EMP1 (By similarity). Also, by regulating protein export, plays an essential role in gametocyte development and thus parasite transmission to the mosquito vector (By similarity).[UniProtKB:Q8I6Z5][UniProtKB:W7JPD9]<ref>PMID:24983235</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Haemamoeba vivax]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Boddey~~, J A~~]]	+	[[Category: Plasmodium vivax]]
-	[[Category: Cowman~~, A F~~]]	+	[[Category: Boddey JA]]
-	[[Category: Czabotar~~, P E~~]]	+	[[Category: Cowman AF]]
-	[[Category: Hodder~~, A N~~]]	+	[[Category: Czabotar PE]]
-	[[Category: Nguyen, W]]	+	[[Category: Hodder AN]]
-	[[Category: Sleebs~~, B E]]~~	+	[[Category: Nguyen W]]
-	~~[[Category: Hydrolase]]~~	+	[[Category: Sleebs BE]]
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Malaria]]~~	+
-	~~[[Category: Plasmepsin]]~~	+
-	~~[[Category: Protease~~]]	+

OCA at 08:40, 8 January 2020

OCA — Wed, 08 Jan 2020 08:40:05 GMT

←Older revision		Revision as of 08:40, 8 January 2020
Line 1:		Line 1:

	==Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-601)==		==Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-601)==
-	<StructureSection load='6c4g' size='340' side='right' caption='[[6c4g]], [[Resolution\|resolution]] 2.39Å' scene=''>	+	<StructureSection load='6c4g' size='340' side='right'caption='[[6c4g]], [[Resolution\|resolution]] 2.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6c4g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemamoeba_vivax Haemamoeba vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C4G FirstGlance]. <br>		<table><tr><td colspan='2'>[[6c4g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemamoeba_vivax Haemamoeba vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C4G FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Haemamoeba vivax]]		[[Category: Haemamoeba vivax]]
		+	[[Category: Large Structures]]
	[[Category: Boddey, J A]]		[[Category: Boddey, J A]]
	[[Category: Cowman, A F]]		[[Category: Cowman, A F]]

OCA at 08:12, 21 February 2019

OCA — Thu, 21 Feb 2019 08:12:24 GMT

←Older revision		Revision as of 08:12, 21 February 2019
Line 3:		Line 3:
	<StructureSection load='6c4g' size='340' side='right' caption='[[6c4g]], [[Resolution\|resolution]] 2.39Å' scene=''>		<StructureSection load='6c4g' size='340' side='right' caption='[[6c4g]], [[Resolution\|resolution]] 2.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6c4g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C4G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6c4g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemamoeba_vivax Haemamoeba vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C4G FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EQG:benzyl+[(6S,7S,10S,13S,18Z)-18-amino-10-cyclohexyl-6-hydroxy-18-imino-7-(2-methylpropyl)-4,9,12-trioxo-1-phenyl-16-oxa-3,8,11,17-tetraazaoctadecan-13-yl]carbamate'>EQG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EQG:benzyl+[(6S,7S,10S,13S,18Z)-18-amino-10-cyclohexyl-6-hydroxy-18-imino-7-(2-methylpropyl)-4,9,12-trioxo-1-phenyl-16-oxa-3,8,11,17-tetraazaoctadecan-13-yl]carbamate'>EQG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c4g OCA], [http://pdbe.org/6c4g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c4g RCSB], [http://www.ebi.ac.uk/pdbsum/6c4g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c4g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c4g OCA], [http://pdbe.org/6c4g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c4g RCSB], [http://www.ebi.ac.uk/pdbsum/6c4g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c4g ProSAT]</span></td></tr>
Line 16:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 6c4g" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6c4g" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Plasmepsin\|Plasmepsin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Haemamoeba vivax]]
	[[Category: Boddey, J A]]		[[Category: Boddey, J A]]
	[[Category: Cowman, A F]]		[[Category: Cowman, A F]]

OCA at 07:38, 14 June 2018

OCA — Thu, 14 Jun 2018 07:38:05 GMT

←Older revision		Revision as of 07:38, 14 June 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6c4g is ~~ON HOLD~~	+	==Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-601)==
		+	<StructureSection load='6c4g' size='340' side='right' caption='[[6c4g]], [[Resolution\|resolution]] 2.39Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6c4g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C4G FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EQG:benzyl+[(6S,7S,10S,13S,18Z)-18-amino-10-cyclohexyl-6-hydroxy-18-imino-7-(2-methylpropyl)-4,9,12-trioxo-1-phenyl-16-oxa-3,8,11,17-tetraazaoctadecan-13-yl]carbamate'>EQG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c4g OCA], [http://pdbe.org/6c4g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c4g RCSB], [http://www.ebi.ac.uk/pdbsum/6c4g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c4g ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plasmepsin V is an aspartyl protease that plays a critical role in the export of proteins bearing the Plasmodium export element (PEXEL) motif (RxLxQ/E/D) to the infected host erythrocyte, and thus the survival of the malaria parasite. Previously, development of transition state PEXEL mimetic inhibitors of plasmepsin V have primarily focused on demonstrating the importance of the P3 Arg and P1 Leu in binding affinity and selectivity. Here, we investigate the importance of the P2 position by incorporating both natural and non-natural amino acids into this position and show disubstituted beta-carbon amino acids convey the greatest potency. Consequently, we show analogues with either cyclohexylglycine or phenylglycine in the P2 position are the most potent inhibitors of plasmepsin V that impair processing of the PEXEL motif in exported proteins resulting in death of P. falciparum asexual stage parasites.

-	~~Authors: Czabotar, P.E~~., Hodder, ~~A.N.~~, ~~Nguyen~~, W., ~~Sleebs~~, ~~B.E.~~, Boddey, J.A.~~, Cowman, A~~.F.	+	Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2 position of PEXEL peptidomimetics.,Nguyen W, Hodder AN, de Lezongard RB, Czabotar PE, Jarman KE, O'Neill MT, Thompson JK, Jousset Sabroux H, Cowman AF, Boddey JA, Sleebs BE Eur J Med Chem. 2018 Jun 25;154:182-198. doi: 10.1016/j.ejmech.2018.05.022. Epub , 2018 May 18. PMID:29800827<ref>PMID:29800827</ref>

-	~~Description: Plasmepsin V from Plasmodium vivax bound to~~ a ~~transition state mimetic (WEHI~~-~~601)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Cowman~~, A.F]]	+	<div class="pdbe-citations 6c4g" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Hodder~~, A.N]]	+	== References ==
-	[[Category: ~~Sleebs~~, B.E]]	+	<references/>
-	[[Category: ~~Boddey~~, J.A]]	+	__TOC__
-	~~[[Category: Czabotar, P.E~~]]	+	</StructureSection>
		+	[[Category: Boddey, J A]]
		+	[[Category: Cowman, A F]]
		+	[[Category: Czabotar, P E]]
		+	[[Category: Hodder, A N]]
	[[Category: Nguyen, W]]		[[Category: Nguyen, W]]
		+	[[Category: Sleebs, B E]]
		+	[[Category: Hydrolase]]
		+	[[Category: Inhibitor]]
		+	[[Category: Malaria]]
		+	[[Category: Plasmepsin]]
		+	[[Category: Protease]]

OCA: Protected "6c4g" [edit=sysop:move=sysop]

OCA — Wed, 17 Jan 2018 05:48:56 GMT

Protected "6c4g" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:48, 17 January 2018

OCA: New page: '''Unreleased structure''' The entry 6c4g is ON HOLD Authors: Czabotar, P.E., Hodder, A.N., Nguyen, W., Sleebs, B.E., Boddey, J.A., Cowman, A.F. Description: Plasmepsin V from Plasmodi...

OCA — Wed, 17 Jan 2018 05:48:55 GMT

New page: '''Unreleased structure''' The entry 6c4g is ON HOLD Authors: Czabotar, P.E., Hodder, A.N., Nguyen, W., Sleebs, B.E., Boddey, J.A., Cowman, A.F. Description: Plasmepsin V from Plasmodi...

New page

'''Unreleased structure'''

The entry 6c4g is ON HOLD

Authors: Czabotar, P.E., Hodder, A.N., Nguyen, W., Sleebs, B.E., Boddey, J.A., Cowman, A.F.

Description: Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-601)
[[Category: Unreleased Structures]]
[[Category: Cowman, A.F]]
[[Category: Hodder, A.N]]
[[Category: Sleebs, B.E]]
[[Category: Boddey, J.A]]
[[Category: Czabotar, P.E]]
[[Category: Nguyen, W]]