6c4z - Revision history

OCA at 09:30, 18 December 2019

OCA — Wed, 18 Dec 2019 09:30:21 GMT

←Older revision		Revision as of 09:30, 18 December 2019
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	==Cross-alpha Amyloid-like Structure alphaAmG - low resolution==		==Cross-alpha Amyloid-like Structure alphaAmG - low resolution==
-	<StructureSection load='6c4z' size='340' side='right' caption='[[6c4z]], [[Resolution\|resolution]] 3.30Å' scene=''>	+	<StructureSection load='6c4z' size='340' side='right'caption='[[6c4z]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6c4z]] is a 18 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C4Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[6c4z]] is a 18 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C4Z FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Liu, L]]		[[Category: Liu, L]]
	[[Category: Zhang, S Q]]		[[Category: Zhang, S Q]]

OCA at 16:12, 15 August 2018

OCA — Wed, 15 Aug 2018 16:12:24 GMT

←Older revision		Revision as of 16:12, 15 August 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6c4z is ~~ON HOLD until Paper~~ Publication	+	==Cross-alpha Amyloid-like Structure alphaAmG - low resolution==
		+	<StructureSection load='6c4z' size='340' side='right' caption='[[6c4z]], [[Resolution\|resolution]] 3.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6c4z]] is a 18 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C4Z FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c4z OCA], [http://pdbe.org/6c4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c4z RCSB], [http://www.ebi.ac.uk/pdbsum/6c4z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c4z ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Amyloids adopt 'cross-beta' structures composed of long, twisted fibrils with beta-strands running perpendicular to the fibril axis. Recently, a toxic peptide was proposed to form amyloid-like cross-alpha structures in solution, with a planar bilayer-like assembly observed in the crystal structure. Here we crystallographically characterize designed peptides that assemble into spiraling cross-alpha amyloid-like structures, which resemble twisted beta-amyloid fibrils. The peptides form helical dimers, stabilized by packing of small and apolar residues, and the dimers further assemble into cross-alpha amyloid-like fibrils with superhelical pitches ranging from 170 A to 200 A. When a small residue that appeared critical for packing was converted to leucine, it resulted in structural rearrangement to a helical polymer. Fluorescently tagged versions of the designed peptides form puncta in mammalian cells, which recover from photobleaching with markedly different kinetics. These structural folds could be potentially useful for directing in vivo protein assemblies with predetermined spacing and stabilities.

-	~~Authors:~~ Liu, L., ~~Zhang, S~~.Q.	+	Designed peptides that assemble into cross-alpha amyloid-like structures.,Zhang SQ, Huang H, Yang J, Kratochvil HT, Lolicato M, Liu Y, Shu X, Liu L, DeGrado WF Nat Chem Biol. 2018 Jul 30. pii: 10.1038/s41589-018-0105-5. doi:, 10.1038/s41589-018-0105-5. PMID:30061717<ref>PMID:30061717</ref>

-	~~Description: Cross~~-~~alpha Amyloid~~-~~like Structure alphaAmG -low resolution~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 6c4z" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Liu, L]]		[[Category: Liu, L]]
-	[[Category: Zhang, S.Q]]	+	[[Category: Zhang, S Q]]
		+	[[Category: Cross-alpha amyloid]]
		+	[[Category: De novo protein]]
		+	[[Category: Protein design]]

OCA at 05:16, 15 February 2018

OCA — Thu, 15 Feb 2018 05:16:59 GMT

←Older revision		Revision as of 05:16, 15 February 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6c4z is ON HOLD	+	The entry 6c4z is ON HOLD until Paper Publication

	Authors: Liu, L., Zhang, S.Q.		Authors: Liu, L., Zhang, S.Q.

OCA: Protected "6c4z" [edit=sysop:move=sysop]

OCA — Wed, 24 Jan 2018 17:19:21 GMT

Protected "6c4z" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:19, 24 January 2018

OCA: New page: '''Unreleased structure''' The entry 6c4z is ON HOLD Authors: Liu, L., Zhang, S.Q. Description: Cross-alpha Amyloid-like Structure alphaAmG -low resolution [[Category: Unreleased Struc...

OCA — Wed, 24 Jan 2018 17:19:20 GMT

New page: '''Unreleased structure''' The entry 6c4z is ON HOLD Authors: Liu, L., Zhang, S.Q. Description: Cross-alpha Amyloid-like Structure alphaAmG -low resolution [[Category: Unreleased Struc...

New page

'''Unreleased structure'''

The entry 6c4z is ON HOLD

Authors: Liu, L., Zhang, S.Q.

Description: Cross-alpha Amyloid-like Structure alphaAmG -low resolution
[[Category: Unreleased Structures]]
[[Category: Liu, L]]
[[Category: Zhang, S.Q]]