6c51 - Revision history

OCA at 09:30, 18 December 2019

OCA — Wed, 18 Dec 2019 09:30:30 GMT

←Older revision		Revision as of 09:30, 18 December 2019
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	==Cross-alpha Amyloid-like Structure alphaAmL==		==Cross-alpha Amyloid-like Structure alphaAmL==
-	<StructureSection load='6c51' size='340' side='right' caption='[[6c51]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='6c51' size='340' side='right'caption='[[6c51]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6c51]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C51 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C51 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6c51]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C51 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C51 FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Liu, L]]		[[Category: Liu, L]]
	[[Category: Zhang, S Q]]		[[Category: Zhang, S Q]]

OCA at 16:12, 15 August 2018

OCA — Wed, 15 Aug 2018 16:12:32 GMT

←Older revision		Revision as of 16:12, 15 August 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6c51 is ~~ON HOLD until Paper~~ Publication	+	==Cross-alpha Amyloid-like Structure alphaAmL==
		+	<StructureSection load='6c51' size='340' side='right' caption='[[6c51]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6c51]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C51 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C51 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c51 OCA], [http://pdbe.org/6c51 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c51 RCSB], [http://www.ebi.ac.uk/pdbsum/6c51 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c51 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Amyloids adopt 'cross-beta' structures composed of long, twisted fibrils with beta-strands running perpendicular to the fibril axis. Recently, a toxic peptide was proposed to form amyloid-like cross-alpha structures in solution, with a planar bilayer-like assembly observed in the crystal structure. Here we crystallographically characterize designed peptides that assemble into spiraling cross-alpha amyloid-like structures, which resemble twisted beta-amyloid fibrils. The peptides form helical dimers, stabilized by packing of small and apolar residues, and the dimers further assemble into cross-alpha amyloid-like fibrils with superhelical pitches ranging from 170 A to 200 A. When a small residue that appeared critical for packing was converted to leucine, it resulted in structural rearrangement to a helical polymer. Fluorescently tagged versions of the designed peptides form puncta in mammalian cells, which recover from photobleaching with markedly different kinetics. These structural folds could be potentially useful for directing in vivo protein assemblies with predetermined spacing and stabilities.

-	~~Authors:~~ Liu, L., ~~Zhang, S~~.Q.	+	Designed peptides that assemble into cross-alpha amyloid-like structures.,Zhang SQ, Huang H, Yang J, Kratochvil HT, Lolicato M, Liu Y, Shu X, Liu L, DeGrado WF Nat Chem Biol. 2018 Jul 30. pii: 10.1038/s41589-018-0105-5. doi:, 10.1038/s41589-018-0105-5. PMID:30061717<ref>PMID:30061717</ref>

-	~~Description: Cross~~-~~alpha Amyloid~~-~~like Structure alphaAmL~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 6c51" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Liu, L]]		[[Category: Liu, L]]
-	[[Category: Zhang, S.Q]]	+	[[Category: Zhang, S Q]]
		+	[[Category: Cross-alpha amyloid]]
		+	[[Category: De novo protein]]
		+	[[Category: Protein design]]

OCA at 05:17, 15 February 2018

OCA — Thu, 15 Feb 2018 05:17:02 GMT

←Older revision		Revision as of 05:17, 15 February 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6c51 is ON HOLD	+	The entry 6c51 is ON HOLD until Paper Publication

	Authors: Liu, L., Zhang, S.Q.		Authors: Liu, L., Zhang, S.Q.

OCA: Protected "6c51" [edit=sysop:move=sysop]

OCA — Wed, 24 Jan 2018 17:19:27 GMT

Protected "6c51" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:19, 24 January 2018

OCA: New page: '''Unreleased structure''' The entry 6c51 is ON HOLD Authors: Liu, L., Zhang, S.Q. Description: Cross-alpha Amyloid-like Structure alphaAmL Category: Unreleased Structures [[Catego...

OCA — Wed, 24 Jan 2018 17:19:25 GMT

New page: '''Unreleased structure''' The entry 6c51 is ON HOLD Authors: Liu, L., Zhang, S.Q. Description: Cross-alpha Amyloid-like Structure alphaAmL Category: Unreleased Structures [[Catego...

New page

'''Unreleased structure'''

The entry 6c51 is ON HOLD

Authors: Liu, L., Zhang, S.Q.

Description: Cross-alpha Amyloid-like Structure alphaAmL
[[Category: Unreleased Structures]]
[[Category: Liu, L]]
[[Category: Zhang, S.Q]]