6c6k - Revision history

OCA at 14:32, 6 March 2024

OCA — Wed, 06 Mar 2024 14:32:36 GMT

←Older revision		Revision as of 14:32, 6 March 2024
Line 3:		Line 3:
	<StructureSection load='6c6k' size='340' side='right'caption='[[6c6k]], [[Resolution\|resolution]] 2.54Å' scene=''>		<StructureSection load='6c6k' size='340' side='right'caption='[[6c6k]], [[Resolution\|resolution]] 2.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6c6k]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C6K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6C6K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6c6k]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Equine_encephalosis_virus Equine encephalosis virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C6K FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.54Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><td class="sblockDat">IFIT1, G10P1, IFI56, IFNAI1, ISG56 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IFIT3, CIG-49, IFI60, IFIT4, ISG60 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c6k OCA], [https://pdbe.org/6c6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c6k RCSB], [https://www.ebi.ac.uk/pdbsum/6c6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c6k ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6c6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c6k OCA], [~~http~~://pdbe.org/6c6k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6c6k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6c6k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6c6k ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/IFIT1_HUMAN IFIT1_HUMAN]] Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.<ref>PMID:19008854</ref> <ref>PMID:19416887</ref> <ref>PMID:21976647</ref> <ref>PMID:23334420</ref> [[http://www.uniprot.org/uniprot/IFIT3_HUMAN IFIT3_HUMAN]] IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.<ref>PMID:17050680</ref> <ref>PMID:20686046</ref> <ref>PMID:21190939</ref> <ref>PMID:21642987</ref> <ref>PMID:21813773</ref>	+	[https://www.uniprot.org/uniprot/IFIT1_HUMAN IFIT1_HUMAN] Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.<ref>PMID:19008854</ref> <ref>PMID:19416887</ref> <ref>PMID:21976647</ref> <ref>PMID:23334420</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Although interferon-induced proteins with tetratricopeptide repeats (IFIT proteins) inhibit infection of many viruses by recognizing their RNA, the regulatory mechanisms involved remain unclear. Here we report a crystal structure of cap 0 (m(7)GpppN) RNA bound to human IFIT1 in complex with the C-terminal domain of human IFIT3. Structural, biochemical, and genetic studies suggest that IFIT3 binding to IFIT1 has dual regulatory functions: (1) extending the half-life of IFIT1 and thereby increasing its steady-state amounts in cells; and (2) allosterically regulating the IFIT1 RNA-binding channel, thereby enhancing the specificity of recognition for cap 0 but not cap 1 (m(7)GpppNm) or 5'-ppp RNA. Mouse Ifit3 lacks this key C-terminal domain and does not bind mouse Ifit1. The IFIT3 interaction with IFIT1 is important for restricting infection of viruses lacking 2'-O methylation in their RNA cap structures. Our experiments establish differences in the regulation of IFIT1 orthologs and define targets for modulation of human IFIT protein activity.	+
-		+
-	Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability.,Johnson B, VanBlargan LA, Xu W, White JP, Shan C, Shi PY, Zhang R, Adhikari J, Gross ML, Leung DW, Diamond MS, Amarasinghe GK Immunity. 2018 Mar 20;48(3):487-499.e5. doi: 10.1016/j.immuni.2018.01.014. Epub, 2018 Mar 8. PMID:29525521<ref>PMID:29525521</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 6c6k" style="background-color:#fffaf0;"></div~~>	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Equine encephalosis virus]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Amarasinghe~~, G K~~]]	+	[[Category: Amarasinghe GK]]
-	[[Category: Johnson, B]]	+	[[Category: Johnson B]]
-	[[Category: Leung~~, D W~~]]	+	[[Category: Leung DW]]
-	[[Category: Xu, W]]	+	[[Category: Xu W]]
-	~~[[Category: Antiviral]]~~	+
-	~~[[Category: Flavivirus]]~~	+
-	~~[[Category: Host defense]]~~	+
-	~~[[Category: Innate immunity]]~~	+
-	~~[[Category: Interferon stimulated gene]]~~	+
-	~~[[Category: Pathogen associated molecular pattern]]~~	+
-	~~[[Category: Rna binding protein-rna complex]]~~	+
-	~~[[Category: Self/non-self rna recognition~~]]	+

OCA at 09:31, 18 December 2019

OCA — Wed, 18 Dec 2019 09:31:29 GMT

←Older revision		Revision as of 09:31, 18 December 2019
Line 1:		Line 1:

	==Structural basis for preferential recognition of cap 0 RNA by a human IFIT1-IFIT3 protein complex==		==Structural basis for preferential recognition of cap 0 RNA by a human IFIT1-IFIT3 protein complex==
-	<StructureSection load='6c6k' size='340' side='right' caption='[[6c6k]], [[Resolution\|resolution]] 2.54Å' scene=''>	+	<StructureSection load='6c6k' size='340' side='right'caption='[[6c6k]], [[Resolution\|resolution]] 2.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6c6k]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C6K FirstGlance]. <br>		<table><tr><td colspan='2'>[[6c6k]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C6K FirstGlance]. <br>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Amarasinghe, G K]]		[[Category: Amarasinghe, G K]]
	[[Category: Johnson, B]]		[[Category: Johnson, B]]

OCA at 08:13, 21 February 2019

OCA — Thu, 21 Feb 2019 08:13:03 GMT

←Older revision		Revision as of 08:13, 21 February 2019
Line 3:		Line 3:
	<StructureSection load='6c6k' size='340' side='right' caption='[[6c6k]], [[Resolution\|resolution]] 2.54Å' scene=''>		<StructureSection load='6c6k' size='340' side='right' caption='[[6c6k]], [[Resolution\|resolution]] 2.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6c6k]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C6K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6c6k]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C6K FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFIT1, G10P1, IFI56, IFNAI1, ISG56 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IFIT3, CIG-49, IFI60, IFIT4, ISG60 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c6k OCA], [http://pdbe.org/6c6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c6k RCSB], [http://www.ebi.ac.uk/pdbsum/6c6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c6k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c6k OCA], [http://pdbe.org/6c6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c6k RCSB], [http://www.ebi.ac.uk/pdbsum/6c6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c6k ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Amarasinghe, G K]]		[[Category: Amarasinghe, G K]]
	[[Category: Johnson, B]]		[[Category: Johnson, B]]

OCA at 05:58, 4 April 2018

OCA — Wed, 04 Apr 2018 05:58:35 GMT

←Older revision		Revision as of 05:58, 4 April 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6c6k is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Structural basis for preferential recognition of cap 0 RNA by a human IFIT1-IFIT3 protein complex==
		+	<StructureSection load='6c6k' size='340' side='right' caption='[[6c6k]], [[Resolution\|resolution]] 2.54Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6c6k]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C6K FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c6k OCA], [http://pdbe.org/6c6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c6k RCSB], [http://www.ebi.ac.uk/pdbsum/6c6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c6k ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IFIT1_HUMAN IFIT1_HUMAN]] Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.<ref>PMID:19008854</ref> <ref>PMID:19416887</ref> <ref>PMID:21976647</ref> <ref>PMID:23334420</ref> [[http://www.uniprot.org/uniprot/IFIT3_HUMAN IFIT3_HUMAN]] IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.<ref>PMID:17050680</ref> <ref>PMID:20686046</ref> <ref>PMID:21190939</ref> <ref>PMID:21642987</ref> <ref>PMID:21813773</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Although interferon-induced proteins with tetratricopeptide repeats (IFIT proteins) inhibit infection of many viruses by recognizing their RNA, the regulatory mechanisms involved remain unclear. Here we report a crystal structure of cap 0 (m(7)GpppN) RNA bound to human IFIT1 in complex with the C-terminal domain of human IFIT3. Structural, biochemical, and genetic studies suggest that IFIT3 binding to IFIT1 has dual regulatory functions: (1) extending the half-life of IFIT1 and thereby increasing its steady-state amounts in cells; and (2) allosterically regulating the IFIT1 RNA-binding channel, thereby enhancing the specificity of recognition for cap 0 but not cap 1 (m(7)GpppNm) or 5'-ppp RNA. Mouse Ifit3 lacks this key C-terminal domain and does not bind mouse Ifit1. The IFIT3 interaction with IFIT1 is important for restricting infection of viruses lacking 2'-O methylation in their RNA cap structures. Our experiments establish differences in the regulation of IFIT1 orthologs and define targets for modulation of human IFIT protein activity.

-	~~Authors: Amarasinghe, G.K~~., ~~Leung~~, D.W., ~~Johnson~~, B., Xu, W.	+	Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability.,Johnson B, VanBlargan LA, Xu W, White JP, Shan C, Shi PY, Zhang R, Adhikari J, Gross ML, Leung DW, Diamond MS, Amarasinghe GK Immunity. 2018 Mar 20;48(3):487-499.e5. doi: 10.1016/j.immuni.2018.01.014. Epub, 2018 Mar 8. PMID:29525521<ref>PMID:29525521</ref>

-	~~Description: Structural basis for preferential recognition of cap 0 RNA by~~ a ~~human IFIT1-IFIT3 protein complex~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Leung~~, ~~D.W~~]]	+	<div class="pdbe-citations 6c6k" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Amarasinghe, G K]]
	[[Category: Johnson, B]]		[[Category: Johnson, B]]
-	[[Category: ~~Amarasinghe~~, ~~G.K~~]]	+	[[Category: Leung, D W]]
	[[Category: Xu, W]]		[[Category: Xu, W]]
		+	[[Category: Antiviral]]
		+	[[Category: Flavivirus]]
		+	[[Category: Host defense]]
		+	[[Category: Innate immunity]]
		+	[[Category: Interferon stimulated gene]]
		+	[[Category: Pathogen associated molecular pattern]]
		+	[[Category: Rna binding protein-rna complex]]
		+	[[Category: Self/non-self rna recognition]]

OCA at 05:17, 15 February 2018

OCA — Thu, 15 Feb 2018 05:17:19 GMT

←Older revision		Revision as of 05:17, 15 February 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6c6k is ON HOLD	+	The entry 6c6k is ON HOLD until Paper Publication

	Authors: Amarasinghe, G.K., Leung, D.W., Johnson, B., Xu, W.		Authors: Amarasinghe, G.K., Leung, D.W., Johnson, B., Xu, W.

OCA: Protected "6c6k" [edit=sysop:move=sysop]

OCA — Wed, 24 Jan 2018 17:23:33 GMT

Protected "6c6k" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:23, 24 January 2018

OCA: New page: '''Unreleased structure''' The entry 6c6k is ON HOLD Authors: Amarasinghe, G.K., Leung, D.W., Johnson, B., Xu, W. Description: Structural basis for preferential recognition of cap 0 RN...

OCA — Wed, 24 Jan 2018 17:23:32 GMT

New page: '''Unreleased structure''' The entry 6c6k is ON HOLD Authors: Amarasinghe, G.K., Leung, D.W., Johnson, B., Xu, W. Description: Structural basis for preferential recognition of cap 0 RN...

New page

'''Unreleased structure'''

The entry 6c6k is ON HOLD

Authors: Amarasinghe, G.K., Leung, D.W., Johnson, B., Xu, W.

Description: Structural basis for preferential recognition of cap 0 RNA by a human IFIT1-IFIT3 protein complex
[[Category: Unreleased Structures]]
[[Category: Leung, D.W]]
[[Category: Johnson, B]]
[[Category: Amarasinghe, G.K]]
[[Category: Xu, W]]