6cbq - Revision history

OCA at 15:00, 4 October 2023

OCA — Wed, 04 Oct 2023 15:00:40 GMT

←Older revision		Revision as of 15:00, 4 October 2023
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	<StructureSection load='6cbq' size='340' side='right'caption='[[6cbq]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='6cbq' size='340' side='right'caption='[[6cbq]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6cbq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CBQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6CBQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6cbq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CBQ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=EVY:(2S)-2-hexyl-N-[(3S)-2-oxooxolan-3-yl]decanamide'>EVY</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Related_structure~~\|~~Related:]]</b></td><td class="sblockDat">[[3szt\|3szt~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EVY:(2S)-2-hexyl-N-[(3S)-2-oxooxolan-3-yl]decanamide'>EVY</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>phzR, qscR, sdiA_2, CAZ03_14830, CAZ10_26210, DC19_16645, HQ52_16845, PAERUG_E15_London_28_01_14_06284, PAMH19_5306 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~287~~ "~~Bacillus aeruginosus~~" (~~Schroeter 1872~~) ~~Trevisan 1885]~~)</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cbq OCA], [https://pdbe.org/6cbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cbq RCSB], [https://www.ebi.ac.uk/pdbsum/6cbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cbq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6cbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cbq OCA], [~~http~~://pdbe.org/6cbq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6cbq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6cbq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6cbq ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9RMS5_PSEAI Q9RMS5_PSEAI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Churchill, M E.A]]~~	+	[[Category: Pseudomonas aeruginosa]]
-	~~[[Category: Wysoczynski-Horita, C L]]~~	+	[[Category: Churchill MEA]]
-	~~[[Category: Luxr-type ahl receptor]]~~	+	[[Category: Wysoczynski-Horita CL]]
-	[[Category: Pseudomonas aeruginosa ~~qscr~~]]	+
-	[[Category: ~~Transcription~~]]	+
-	[[Category: ~~Transcription~~-~~agonist complex~~]]	+

OCA at 08:24, 27 November 2019

OCA — Wed, 27 Nov 2019 08:24:11 GMT

←Older revision		Revision as of 08:24, 27 November 2019
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	==Crystal structure of QscR bound to agonist S3==		==Crystal structure of QscR bound to agonist S3==
-	<StructureSection load='6cbq' size='340' side='right' caption='[[6cbq]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='6cbq' size='340' side='right'caption='[[6cbq]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6cbq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CBQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6cbq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CBQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EVY:(2S)-2-hexyl-N-[(3S)-2-oxooxolan-3-yl]decanamide'>EVY</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EVY:(2S)-2-hexyl-N-[(3S)-2-oxooxolan-3-yl]decanamide'>EVY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3szt\|3szt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3szt\|3szt]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">phzR, qscR, sdiA_2, CAZ03_14830, CAZ10_26210, DC19_16645, HQ52_16845, PAERUG_E15_London_28_01_14_06284, PAMH19_5306 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cbq OCA], [http://pdbe.org/6cbq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cbq RCSB], [http://www.ebi.ac.uk/pdbsum/6cbq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cbq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cbq OCA], [http://pdbe.org/6cbq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cbq RCSB], [http://www.ebi.ac.uk/pdbsum/6cbq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cbq ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Churchill, M E.A]]		[[Category: Churchill, M E.A]]
	[[Category: Wysoczynski-Horita, C L]]		[[Category: Wysoczynski-Horita, C L]]

OCA at 06:36, 28 February 2018

OCA — Wed, 28 Feb 2018 06:36:27 GMT

←Older revision		Revision as of 06:36, 28 February 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6cbq is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of QscR bound to agonist S3==
		+	<StructureSection load='6cbq' size='340' side='right' caption='[[6cbq]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6cbq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CBQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EVY:(2S)-2-hexyl-N-[(3S)-2-oxooxolan-3-yl]decanamide'>EVY</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3szt\|3szt]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cbq OCA], [http://pdbe.org/6cbq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cbq RCSB], [http://www.ebi.ac.uk/pdbsum/6cbq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cbq ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pseudomonas aeruginosa is an opportunistic pathogen that uses the process of quorum sensing (QS) to coordinate the expression of many virulence genes. During quorum sensing, N-acyl-homoserine lactone (AHL) signaling molecules regulate the activity of three LuxR-type transcription factors, LasR, RhlR, and QscR. To better understand P. aeruginosa QS signal reception, we examined the mechanism underlying the response of QscR to synthetic agonists and antagonists using biophysical and structural approaches. The structure of QscR bound to a synthetic agonist reveals a novel mode of ligand binding supporting a general mechanism for agonist activity. In turn, antagonists of QscR with partial agonist activity were found to destabilize and greatly impair QscR dimerization and DNA binding. These results highlight the diversity of LuxR-type receptor responses to small molecule agonists and antagonists and demonstrate the potential for chemical strategies for the selective targeting of individual quorum-sensing systems. This article is protected by copyright. All rights reserved.

-	~~Authors: Churchill, M.E.A~~., Wysoczynski-Horita, C.L.	+	Mechanism of agonism and antagonism of the Pseudomonas aeruginosa quorum sensing regulator QscR with non-native ligands.,Wysoczynski-Horita CL, Boursier ME, Hill R, Hansen K, Blackwell HE, Churchill MEA Mol Microbiol. 2018 Feb 13. doi: 10.1111/mmi.13930. PMID:29437248<ref>PMID:29437248</ref>

-	~~Description: Crystal structure~~ of ~~QscR bound to agonist S3~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: Wysoczynski-Horita, C.L]]	+	<div class="pdbe-citations 6cbq" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Churchill, M.E.A~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Churchill, M E.A]]
		+	[[Category: Wysoczynski-Horita, C L]]
		+	[[Category: Luxr-type ahl receptor]]
		+	[[Category: Pseudomonas aeruginosa qscr]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription-agonist complex]]

OCA: Protected "6cbq" [edit=sysop:move=sysop]

OCA — Thu, 15 Feb 2018 05:20:21 GMT

Protected "6cbq" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:20, 15 February 2018

OCA: New page: '''Unreleased structure''' The entry 6cbq is ON HOLD until Paper Publication Authors: Churchill, M.E.A., Wysoczynski-Horita, C.L. Description: Crystal structure of QscR bound to agonis...

OCA — Thu, 15 Feb 2018 05:20:20 GMT

New page: '''Unreleased structure''' The entry 6cbq is ON HOLD until Paper Publication Authors: Churchill, M.E.A., Wysoczynski-Horita, C.L. Description: Crystal structure of QscR bound to agonis...

New page

'''Unreleased structure'''

The entry 6cbq is ON HOLD until Paper Publication

Authors: Churchill, M.E.A., Wysoczynski-Horita, C.L.

Description: Crystal structure of QscR bound to agonist S3
[[Category: Unreleased Structures]]
[[Category: Wysoczynski-Horita, C.L]]
[[Category: Churchill, M.E.A]]