6cep - Revision history

OCA at 15:02, 4 October 2023

OCA — Wed, 04 Oct 2023 15:02:39 GMT

←Older revision		Revision as of 15:02, 4 October 2023
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	<StructureSection load='6cep' size='340' side='right'caption='[[6cep]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6cep' size='340' side='right'caption='[[6cep]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6cep]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CEP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6CEP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6cep]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CEP FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=NAD:NICOTINAMIDE~~-~~ADENINE-DINUCLEOTIDE'>NAD</scene>~~, ~~<scene name='pdbligand=OXM:OXAMIC+ACID'>OXM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[http:~~/~~/en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase]~~, ~~with EC number [http~~:~~//www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=OXM:OXAMIC+ACID'>OXM</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6cep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cep OCA], [~~http~~://pdbe.org/6cep PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6cep RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6cep PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6cep ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cep OCA], [https://pdbe.org/6cep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cep RCSB], [https://www.ebi.ac.uk/pdbsum/6cep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cep ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LDHB_PIG LDHB_PIG]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: L-lactate dehydrogenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Andrews, B]]	+	[[Category: Andrews B]]
-	[[Category: Dunham~~, C M~~]]	+	[[Category: Dunham CM]]
-	[[Category: Dyer~~, R B~~]]	+	[[Category: Dyer RB]]
-	[[Category: Hoffer~~, E D]]~~	+	[[Category: Hoffer ED]]
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Ternary complex~~]]	+

OCA at 10:44, 1 January 2020

OCA — Wed, 01 Jan 2020 10:44:03 GMT

←Older revision		Revision as of 10:44, 1 January 2020
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	==Sus scrofa heart L-lactate dehydrogenase ternary complex with NADH and oxamate==		==Sus scrofa heart L-lactate dehydrogenase ternary complex with NADH and oxamate==
-	<StructureSection load='6cep' size='340' side='right' caption='[[6cep]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='6cep' size='340' side='right'caption='[[6cep]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6cep]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CEP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CEP FirstGlance]. <br>		<table><tr><td colspan='2'>[[6cep]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CEP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CEP FirstGlance]. <br>
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	==See Also==		==See Also==
-	*[[Lactate ~~Dehydrogenase~~\|Lactate ~~Dehydrogenase~~]]	+	*[[Lactate dehydrogenase 3D structures\|Lactate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
		+	[[Category: Large Structures]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Andrews, B]]		[[Category: Andrews, B]]

OCA at 06:44, 9 January 2019

OCA — Wed, 09 Jan 2019 06:44:59 GMT

←Older revision		Revision as of 06:44, 9 January 2019
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cep OCA], [http://pdbe.org/6cep PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cep RCSB], [http://www.ebi.ac.uk/pdbsum/6cep PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cep ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cep OCA], [http://pdbe.org/6cep PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cep RCSB], [http://www.ebi.ac.uk/pdbsum/6cep PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cep ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lactate dehydrogenase (LDH) has recently garnered attention as an attractive target for cancer therapies, owing to the enzyme's critical role in cellular metabolism. Current inhibition strategies, employing substrate or cofactor analogues, are insufficiently specific for use as pharmaceutical agents. The possibility of allosteric inhibition of LDH was postulated on the basis of theoretical docking studies of a small molecule inhibitor to LDH. The present study examined structural analogues of this proposed inhibitor to gauge its potency and attempt to elucidate the molecular mechanism of action. These analogues display encouraging in vitro inhibition of porcine heart LDH, including micromolar Ki values and a maximum inhibition of up to 50% in the steady state. Furthermore, Michaelis-Menten kinetics and fluorescence data both suggest the simple, acetaminophen derivatives are non-competitive in binding to the enzyme. Kinetic comparisons of a panel of increasingly decorated structural analogues imply that the binding is specific, and the small molecule core provides a privileged scaffold for further pharmaceutical development of a novel, allosteric drug.
		+
		+	Small molecule cores demonstrate non-competitive inhibition of lactate dehydrogenase.,Andrews BA, Dyer RB Medchemcomm. 2018 Jul 13;9(8):1369-1376. doi: 10.1039/c8md00309b. eCollection, 2018 Aug 1. PMID:30151092<ref>PMID:30151092</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6cep" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Lactate Dehydrogenase\|Lactate Dehydrogenase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 05:35, 27 June 2018

OCA — Wed, 27 Jun 2018 05:35:47 GMT

←Older revision		Revision as of 05:35, 27 June 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6cep is ~~ON HOLD until Paper Publication~~	+	==Sus scrofa heart L-lactate dehydrogenase ternary complex with NADH and oxamate==
-		+	<StructureSection load='6cep' size='340' side='right' caption='[[6cep]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6cep]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CEP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CEP FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=OXM:OXAMIC+ACID'>OXM</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cep OCA], [http://pdbe.org/6cep PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cep RCSB], [http://www.ebi.ac.uk/pdbsum/6cep PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cep ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: L-lactate dehydrogenase]]
		+	[[Category: Sus scrofa]]
		+	[[Category: Andrews, B]]
		+	[[Category: Dunham, C M]]
		+	[[Category: Dyer, R B]]
		+	[[Category: Hoffer, E D]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Ternary complex]]

OCA: Protected "6cep" [edit=sysop:move=sysop]

OCA — Wed, 04 Apr 2018 04:37:17 GMT

Protected "6cep" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:37, 4 April 2018

OCA: New page: '''Unreleased structure''' The entry 6cep is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 04 Apr 2018 04:37:16 GMT

New page: '''Unreleased structure''' The entry 6cep is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6cep is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]