6cg7 - Revision history

OCA at 15:04, 4 October 2023

OCA — Wed, 04 Oct 2023 15:04:13 GMT

←Older revision		Revision as of 15:04, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='6cg7' size='340' side='right'caption='[[6cg7]], [[Resolution\|resolution]] 2.71Å' scene=''>		<StructureSection load='6cg7' size='340' side='right'caption='[[6cg7]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6cg7]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CG7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6CG7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6cg7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CG7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.705Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6cg6\|6cg6]]~~, [[~~6cgb~~\|~~6cgb]], [[6cgs\|6cgs]], [[6cgu\|6cgu~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Cdh22 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cg7 OCA], [https://pdbe.org/6cg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cg7 RCSB], [https://www.ebi.ac.uk/pdbsum/6cg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cg7 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6cg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cg7 OCA], [~~http~~://pdbe.org/6cg7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6cg7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6cg7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6cg7 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CAD22_MOUSE CAD22_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues.	+	[https://www.uniprot.org/uniprot/CAD22_MOUSE CAD22_MOUSE] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Brasch, J]]	+	[[Category: Brasch J]]
-	[[Category: Harrison~~, O J~~]]	+	[[Category: Harrison OJ]]
-	[[Category: Shapiro, L]]	+	[[Category: Shapiro L]]
-	~~[[Category: Cadherin ec domain dimer extracellular]]~~	+
-	~~[[Category: Cell adhesion~~]]	+

OCA at 08:25, 27 November 2019

OCA — Wed, 27 Nov 2019 08:25:47 GMT

←Older revision		Revision as of 08:25, 27 November 2019
Line 1:		Line 1:

	==mouse cadherin-22 EC1-2 adhesive fragment==		==mouse cadherin-22 EC1-2 adhesive fragment==
-	<StructureSection load='6cg7' size='340' side='right' caption='[[6cg7]], [[Resolution\|resolution]] 2.71Å' scene=''>	+	<StructureSection load='6cg7' size='340' side='right'caption='[[6cg7]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6cg7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CG7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6cg7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CG7 FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 6cg7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6cg7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cadherin 3D structures\|Cadherin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Brasch, J]]		[[Category: Brasch, J]]

OCA at 07:45, 23 May 2018

OCA — Wed, 23 May 2018 07:45:55 GMT

←Older revision		Revision as of 07:45, 23 May 2018
Line 3:		Line 3:
	<StructureSection load='6cg7' size='340' side='right' caption='[[6cg7]], [[Resolution\|resolution]] 2.71Å' scene=''>		<StructureSection load='6cg7' size='340' side='right' caption='[[6cg7]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6cg7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CG7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6cg7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CG7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6cg6\|6cg6]], [[6cgb\|6cgb]], [[6cgs\|6cgs]], [[6cgu\|6cgu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6cg6\|6cg6]], [[6cgb\|6cgb]], [[6cgs\|6cgs]], [[6cgu\|6cgu]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdh22 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cg7 OCA], [http://pdbe.org/6cg7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cg7 RCSB], [http://www.ebi.ac.uk/pdbsum/6cg7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cg7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cg7 OCA], [http://pdbe.org/6cg7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cg7 RCSB], [http://www.ebi.ac.uk/pdbsum/6cg7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cg7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CAD22_MOUSE CAD22_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues.		[[http://www.uniprot.org/uniprot/CAD22_MOUSE CAD22_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Type II cadherins are cell-cell adhesion proteins critical for tissue patterning and neuronal targeting but whose molecular binding code remains poorly understood. Here, we delineate binding preferences for type II cadherin cell-adhesive regions, revealing extensive heterophilic interactions between specific pairs, in addition to homophilic interactions. Three distinct specificity groups emerge from our analysis with members that share highly similar heterophilic binding patterns and favor binding to one another. Structures of adhesive fragments from each specificity group confirm near-identical dimer topology conserved throughout the family, allowing interface residues whose conservation corresponds to specificity preferences to be identified. We show that targeted mutation of these residues converts binding preferences between specificity groups in biophysical and co-culture assays. Our results provide a detailed understanding of the type II cadherin interaction map and a basis for defining their role in tissue patterning and for the emerging importance of their heterophilic interactions in neural connectivity.
		+
		+	Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior.,Brasch J, Katsamba PS, Harrison OJ, Ahlsen G, Troyanovsky RB, Indra I, Kaczynska A, Kaeser B, Troyanovsky S, Honig B, Shapiro L Cell Rep. 2018 May 8;23(6):1840-1852. doi: 10.1016/j.celrep.2018.04.012. PMID:29742438<ref>PMID:29742438</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6cg7" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Brasch, J]]		[[Category: Brasch, J]]
	[[Category: Harrison, O J]]		[[Category: Harrison, O J]]

OCA at 06:17, 9 May 2018

OCA — Wed, 09 May 2018 06:17:59 GMT

←Older revision		Revision as of 06:17, 9 May 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6cg7 is ~~ON HOLD~~	+	==mouse cadherin-22 EC1-2 adhesive fragment==
-		+	<StructureSection load='6cg7' size='340' side='right' caption='[[6cg7]], [[Resolution\|resolution]] 2.71Å' scene=''>
-	~~Authors~~: ~~Brasch~~, J., ~~Harrison~~, O.J., ~~Shapiro~~, L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6cg7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CG7 FirstGlance]. <br>
-	~~Description~~: ~~mouse cadherin~~-~~22 EC1~~-~~2 adhesive fragment~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6cg6\|6cg6]], [[6cgb\|6cgb]], [[6cgs\|6cgs]], [[6cgu\|6cgu]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cg7 OCA], [http://pdbe.org/6cg7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cg7 RCSB], [http://www.ebi.ac.uk/pdbsum/6cg7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cg7 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAD22_MOUSE CAD22_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Brasch, J]]
		+	[[Category: Harrison, O J]]
	[[Category: Shapiro, L]]		[[Category: Shapiro, L]]
-	[[Category: ~~Harrison, O.J~~]]	+	[[Category: Cadherin ec domain dimer extracellular]]
-	[[Category: ~~Brasch, J~~]]	+	[[Category: Cell adhesion]]

OCA: Protected "6cg7" [edit=sysop:move=sysop]

OCA — Wed, 28 Feb 2018 05:02:55 GMT

Protected "6cg7" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:02, 28 February 2018

OCA: New page: '''Unreleased structure''' The entry 6cg7 is ON HOLD Authors: Brasch, J., Harrison, O.J., Shapiro, L. Description: mouse cadherin-22 EC1-2 adhesive fragment [[Category: Unreleased Stru...

OCA — Wed, 28 Feb 2018 05:02:53 GMT

New page: '''Unreleased structure''' The entry 6cg7 is ON HOLD Authors: Brasch, J., Harrison, O.J., Shapiro, L. Description: mouse cadherin-22 EC1-2 adhesive fragment [[Category: Unreleased Stru...

New page

'''Unreleased structure'''

The entry 6cg7 is ON HOLD

Authors: Brasch, J., Harrison, O.J., Shapiro, L.

Description: mouse cadherin-22 EC1-2 adhesive fragment
[[Category: Unreleased Structures]]
[[Category: Shapiro, L]]
[[Category: Harrison, O.J]]
[[Category: Brasch, J]]