6cka - Revision history

OCA at 09:45, 18 December 2019

OCA — Wed, 18 Dec 2019 09:45:52 GMT

←Older revision		Revision as of 09:45, 18 December 2019
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	==Crystal Structure of Paratox==		==Crystal Structure of Paratox==
-	<StructureSection load='6cka' size='340' side='right' caption='[[6cka]], [[Resolution\|resolution]] 1.56Å' scene=''>	+	<StructureSection load='6cka' size='340' side='right'caption='[[6cka]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6cka]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strp3 Strp3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CKA FirstGlance]. <br>		<table><tr><td colspan='2'>[[6cka]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strp3 Strp3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CKA FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Strp3]]		[[Category: Strp3]]
	[[Category: Prehna, G]]		[[Category: Prehna, G]]

OCA at 08:28, 21 February 2019

OCA — Thu, 21 Feb 2019 08:28:09 GMT

←Older revision		Revision as of 08:28, 21 February 2019
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	<StructureSection load='6cka' size='340' side='right' caption='[[6cka]], [[Resolution\|resolution]] 1.56Å' scene=''>		<StructureSection load='6cka' size='340' side='right' caption='[[6cka]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6cka]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CKA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6cka]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strp3 Strp3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CKA FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SpyM3_1300 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198466 STRP3])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cka OCA], [http://pdbe.org/6cka PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cka RCSB], [http://www.ebi.ac.uk/pdbsum/6cka PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cka ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cka OCA], [http://pdbe.org/6cka PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cka RCSB], [http://www.ebi.ac.uk/pdbsum/6cka PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cka ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Horizontal gene transfer is an important means of bacterial evolution. This includes natural genetic transformation, where bacterial cells become "competent" and DNA is acquired from the extracellular environment. Natural competence in many species of Streptococcus, is regulated by quorum sensing via the ComRS receptor-signal pair. The ComR-XIP (mature ComS peptide) complex induces expression of the alternative sigma factor SigX, which targets RNA polymerase to CIN-box promoters to activate genes involved in DNA uptake and recombination. In addition, the widely distributed Streptococcus prophage gene paratox (prx) also contains a CIN-box, and here we demonstrate it to be transcriptionally activated by XIP. In vitro experiments demonstrate that Prx binds ComR directly and prevents the ComR-XIP complex from interacting with DNA. Mutations of prx in vivo caused increased expression of the late competence gene ssb when induced with XIP as compared to wild-type, and Prx orthologues are able to inhibit ComR activation by XIP in a reporter strain which lacks an endogenous prx. Additionally, an X-ray crystal structure of Prx reveals a unique fold that implies a novel molecular mechanism to inhibit ComR. Overall, our results suggest Prx functions to inhibit the acquisition of new DNA by Streptococcus.
		+
		+	The conserved mosaic prophage protein paratox inhibits the natural competence regulator ComR in Streptococcus.,Mashburn-Warren L, Goodman SD, Federle MJ, Prehna G Sci Rep. 2018 Nov 8;8(1):16535. doi: 10.1038/s41598-018-34816-7. PMID:30409983<ref>PMID:30409983</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6cka" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Strp3]]
	[[Category: Prehna, G]]		[[Category: Prehna, G]]
	[[Category: Natural competence]]		[[Category: Natural competence]]

OCA at 08:13, 14 November 2018

OCA — Wed, 14 Nov 2018 08:13:56 GMT

←Older revision		Revision as of 08:13, 14 November 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6cka is ~~ON HOLD until Paper Publication~~	+	==Crystal Structure of Paratox==
-		+	<StructureSection load='6cka' size='340' side='right' caption='[[6cka]], [[Resolution\|resolution]] 1.56Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6cka]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CKA FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cka OCA], [http://pdbe.org/6cka PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cka RCSB], [http://www.ebi.ac.uk/pdbsum/6cka PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cka ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Prehna, G]]
		+	[[Category: Natural competence]]
		+	[[Category: Prophage]]
		+	[[Category: Protein binding]]
		+	[[Category: Streptococcus]]
		+	[[Category: Viral protein]]

OCA: Protected "6cka" [edit=sysop:move=sysop]

OCA — Thu, 08 Mar 2018 03:50:32 GMT

Protected "6cka" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:50, 8 March 2018

OCA: New page: '''Unreleased structure''' The entry 6cka is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Thu, 08 Mar 2018 03:50:31 GMT

New page: '''Unreleased structure''' The entry 6cka is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6cka is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]