6ckh - Revision history

OCA at 15:06, 4 October 2023

OCA — Wed, 04 Oct 2023 15:06:38 GMT

←Older revision		Revision as of 15:06, 4 October 2023
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	<StructureSection load='6ckh' size='340' side='right'caption='[[6ckh]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6ckh' size='340' side='right'caption='[[6ckh]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ckh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CKH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6CKH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ckh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Manduca_sexta Manduca sexta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CKH FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ckh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ckh OCA], [~~http~~://pdbe.org/6ckh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ckh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ckh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ckh ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ckh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ckh OCA], [https://pdbe.org/6ckh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ckh RCSB], [https://www.ebi.ac.uk/pdbsum/6ckh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ckh ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q86RS6_MANSE Q86RS6_MANSE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hu, Y~~]]	+	[[Category: Manduca sexta]]
-	[[Category: ~~Immune system]]~~	+	[[Category: Hu Y]]
-	~~[[Category: Innate immune system]]~~	+
-	~~[[Category: Pattern recognition receptor]]~~	+
-	~~[[Category: Peptidoglycan~~]]	+

OCA at 22:41, 5 June 2019

OCA — Wed, 05 Jun 2019 22:41:24 GMT

←Older revision		Revision as of 22:41, 5 June 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6ckh is ~~ON HOLD~~	+	==Manduca sexta Peptidoglycan Recognition Protein-1==
		+	<StructureSection load='6ckh' size='340' side='right'caption='[[6ckh]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6ckh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CKH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CKH FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ckh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ckh OCA], [http://pdbe.org/6ckh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ckh RCSB], [http://www.ebi.ac.uk/pdbsum/6ckh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ckh ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Peptidoglycan recognition proteins (PGRPs) recognize bacteria through their unique cell wall constituent, peptidoglycans (PGs). PGRPs are conserved from insects to mammals and all function in antibacterial defense. In the tobacco hornworm Manduca sexta, PGRP1 and microbe binding protein (MBP) interact with PGs and hemolymph protease-14 precursor (proHP14) to yield active HP14. HP14 triggers a serine protease network that produces active phenoloxidase (PO), Spatzle, and other cytokines to stimulate immune responses. PGRP1 binds preferentially to diaminopimelic acid (DAP)-PGs of Gram-negative bacteria and Gram-positive Bacillus and Clostridium species than Lys-PGs of other Gram-positive bacteria. In this study, we synthesized DAP- and Lys-muramyl pentapeptide (MPP) and monitored their associations with M. sexta PGRP1 by surface plasmon resonance. The Kd values (0.57muM for DAP-MPP and 45.6muM for Lys-MPP) agree with the differential recognition of DAP- and Lys-PGs. To reveal its structural basis, we produced the PGRP1 in insect cells and determined its structure at a resolution of 2.1A. The protein adopts a fold similar to those from other PGRPs with a classical L-shaped PG-binding groove. A unique loop lining the shallow groove suggests a different ligand-binding mechanism. In summary, this study provided new insights into the PG recognition by PGRPs, a critical first step that initiates the serine protease cascade.

-	~~Authors~~:	+	The three-dimensional structure and recognition mechanism of Manduca sexta peptidoglycan recognition protein-1.,Hu Y, Cao X, Li X, Wang Y, Boons GJ, Deng J, Jiang H Insect Biochem Mol Biol. 2019 May;108:44-52. doi: 10.1016/j.ibmb.2019.03.001., Epub 2019 Mar 21. PMID:30905759<ref>PMID:30905759</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6ckh" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Hu, Y]]
		+	[[Category: Immune system]]
		+	[[Category: Innate immune system]]
		+	[[Category: Pattern recognition receptor]]
		+	[[Category: Peptidoglycan]]

OCA at 04:11, 29 May 2019

OCA — Wed, 29 May 2019 04:11:36 GMT

←Older revision		Revision as of 04:11, 29 May 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ckh is ON HOLD ~~until sometime in the future~~	+	The entry 6ckh is ON HOLD

	Authors:		Authors:

OCA at 04:22, 3 April 2019

OCA — Wed, 03 Apr 2019 04:22:04 GMT

←Older revision		Revision as of 04:22, 3 April 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ckh is ON HOLD	+	The entry 6ckh is ON HOLD until sometime in the future

	Authors:		Authors:

OCA: Protected "6ckh" [edit=sysop:move=sysop]

OCA — Thu, 08 Mar 2018 03:50:55 GMT

Protected "6ckh" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:50, 8 March 2018

OCA: New page: '''Unreleased structure''' The entry 6ckh is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 08 Mar 2018 03:50:53 GMT

New page: '''Unreleased structure''' The entry 6ckh is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ckh is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]