6cnv - Revision history

OCA at 09:00, 11 November 2020

OCA — Wed, 11 Nov 2020 09:00:16 GMT

←Older revision		Revision as of 09:00, 11 November 2020
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	==INFLUENZA B/BRISBANE HEMAGGLUTININ FAB CR9115 SD84H COMPLEX==		==INFLUENZA B/BRISBANE HEMAGGLUTININ FAB CR9115 SD84H COMPLEX==
-	<StructureSection load='6cnv' size='340' side='right' caption='[[6cnv]], [[Resolution\|resolution]] 4.10Å' scene=''>	+	<StructureSection load='6cnv' size='340' side='right'caption='[[6cnv]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6cnv]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CNV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6CNV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6cnv]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpt4 Bpt4], [http://en.wikipedia.org/wiki/Human Human], [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/townsville/202/2008) Influenza b virus (b/townsville/202/2008)] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CNV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6CNV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6cnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cnv OCA], [http://pdbe.org/6cnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cnv RCSB], [http://www.ebi.ac.uk/pdbsum/6cnv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cnv ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1275762 Influenza B virus (B/Townsville/202/2008)])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6cnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cnv OCA], [http://pdbe.org/6cnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cnv RCSB], [http://www.ebi.ac.uk/pdbsum/6cnv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cnv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6cnv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6cnv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bpt4]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
		+	[[Category: Synthetic construct sequences]]
	[[Category: Luo, J]]		[[Category: Luo, J]]
	[[Category: Obmolova, G]]		[[Category: Obmolova, G]]

OCA at 08:14, 14 November 2018

OCA — Wed, 14 Nov 2018 08:14:49 GMT

←Older revision		Revision as of 08:14, 14 November 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6cnv is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==INFLUENZA B/BRISBANE HEMAGGLUTININ FAB CR9115 SD84H COMPLEX==
		+	<StructureSection load='6cnv' size='340' side='right' caption='[[6cnv]], [[Resolution\|resolution]] 4.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6cnv]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CNV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cnv OCA], [http://pdbe.org/6cnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cnv RCSB], [http://www.ebi.ac.uk/pdbsum/6cnv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cnv ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/U3RVK6_9INFB U3RVK6_9INFB]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324] [[http://www.uniprot.org/uniprot/G4WYG8_9INFB G4WYG8_9INFB]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Broadly neutralizing antibodies against highly variable pathogens have stimulated the design of vaccines and therapeutics. We report the use of diverse camelid single-domain antibodies to influenza virus hemagglutinin to generate multidomain antibodies with impressive breadth and potency. Multidomain antibody MD3606 protects mice against influenza A and B infection when administered intravenously or expressed locally from a recombinant adeno-associated virus vector. Crystal and single-particle electron microscopy structures of these antibodies with hemagglutinins from influenza A and B viruses reveal binding to highly conserved epitopes. Collectively, our findings demonstrate that multidomain antibodies targeting multiple epitopes exhibit enhanced virus cross-reactivity and potency. In combination with adeno-associated virus-mediated gene delivery, they may provide an effective strategy to prevent infection with influenza virus and other highly variable pathogens.

-	~~Authors: Luo~~, J., ~~Obmolova~~, G.	+	Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.,Laursen NS, Friesen RHE, Zhu X, Jongeneelen M, Blokland S, Vermond J, van Eijgen A, Tang C, van Diepen H, Obmolova G, van der Neut Kolfschoten M, Zuijdgeest D, Straetemans R, Hoffman RMB, Nieusma T, Pallesen J, Turner HL, Bernard SM, Ward AB, Luo J, Poon LLM, Tretiakova AP, Wilson JM, Limberis MP, Vogels R, Brandenburg B, Kolkman JA, Wilson IA Science. 2018 Nov 2;362(6414):598-602. doi: 10.1126/science.aaq0620. PMID:30385580<ref>PMID:30385580</ref>

-	~~Description: INFLUENZA B~~/~~BRISBANE HEMAGGLUTININ FAB CR9115 SD84H COMPLEX~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Obmolova, G]]~~	+	<div class="pdbe-citations 6cnv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Luo, J]]		[[Category: Luo, J]]
		+	[[Category: Obmolova, G]]
		+	[[Category: Hemagglutinin]]
		+	[[Category: Humanization]]
		+	[[Category: Influenza]]
		+	[[Category: Single domain antibody]]
		+	[[Category: Viral protein]]
		+	[[Category: Viral protein-immune system complex]]

OCA at 04:39, 4 April 2018

OCA — Wed, 04 Apr 2018 04:39:02 GMT

←Older revision		Revision as of 04:39, 4 April 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6cnv is ON HOLD	+	The entry 6cnv is ON HOLD until Paper Publication

	Authors: Luo, J., Obmolova, G.		Authors: Luo, J., Obmolova, G.

OCA: Protected "6cnv" [edit=sysop:move=sysop]

OCA — Wed, 21 Mar 2018 06:08:57 GMT

Protected "6cnv" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:08, 21 March 2018

OCA: New page: '''Unreleased structure''' The entry 6cnv is ON HOLD Authors: Luo, J., Obmolova, G. Description: INFLUENZA B/BRISBANE HEMAGGLUTININ FAB CR9115 SD84H COMPLEX [[Category: Unreleased Stru...

OCA — Wed, 21 Mar 2018 06:08:56 GMT

New page: '''Unreleased structure''' The entry 6cnv is ON HOLD Authors: Luo, J., Obmolova, G. Description: INFLUENZA B/BRISBANE HEMAGGLUTININ FAB CR9115 SD84H COMPLEX [[Category: Unreleased Stru...

New page

'''Unreleased structure'''

The entry 6cnv is ON HOLD

Authors: Luo, J., Obmolova, G.

Description: INFLUENZA B/BRISBANE HEMAGGLUTININ FAB CR9115 SD84H COMPLEX
[[Category: Unreleased Structures]]
[[Category: Obmolova, G]]
[[Category: Luo, J]]