6cou - Revision history

OCA at 09:00, 11 November 2020

OCA — Wed, 11 Nov 2020 09:00:06 GMT

←Older revision		Revision as of 09:00, 11 November 2020
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	==CSP2-E1Ad10==		==CSP2-E1Ad10==
-	<StructureSection load='6cou' size='340' side='right' caption='[[6cou]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='6cou' size='340' side='right'caption='[[6cou]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6cou]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6COU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6COU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6cou]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6COU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6COU FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAS:D-ASPARTIC+ACID'>DAS</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAS:D-ASPARTIC+ACID'>DAS</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6cou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cou OCA], [http://pdbe.org/6cou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cou RCSB], [http://www.ebi.ac.uk/pdbsum/6cou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cou ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6cou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cou OCA], [http://pdbe.org/6cou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cou RCSB], [http://www.ebi.ac.uk/pdbsum/6cou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cou ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Yang, Y]]		[[Category: Yang, Y]]
	[[Category: Csp]]		[[Category: Csp]]

OCA at 07:26, 29 August 2018

OCA — Wed, 29 Aug 2018 07:26:37 GMT

←Older revision		Revision as of 07:26, 29 August 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6cou is ~~ON HOLD until Paper~~ Publication	+	==CSP2-E1Ad10==
		+	<StructureSection load='6cou' size='340' side='right' caption='[[6cou]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6cou]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6COU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6COU FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAS:D-ASPARTIC+ACID'>DAS</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cou OCA], [http://pdbe.org/6cou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cou RCSB], [http://www.ebi.ac.uk/pdbsum/6cou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cou ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CSP2_STRPN CSP2_STRPN]] Acts as a pheromone, induces cells to develop competence for genetic transformation.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Streptococcus pneumoniae is an important pathogen that utilizes quorum sensing (QS) to regulate genetic transformation, virulence, and biofilm formation. The competence-stimulating peptide (CSP) is a 17-amino acid signal peptide that is used by S. pneumoniae to trigger QS. S. pneumoniae strains can be divided into two main specificity groups based on the CSP signal they produce (CSP1 or CSP2) and their compatible receptors (ComD1 or ComD2, respectively). Modulation of QS in S. pneumoniae can be achieved by targeting the CSP:ComD interaction using synthetic CSP analogues. However, to rationally design CSP-based QS modulators with enhanced activities, an in-depth understanding of the structural features that are required for receptor binding is needed. Herein, we report a comprehensive in-solution three-dimensional structural characterization of eight CSP1 and CSP2 analogues with varied biological activities using nuclear magnetic resonance spectroscopy. Analysis of these structures revealed two distinct hydrophobic patches required for effective ComD1 and ComD2 binding.

-	~~Authors:~~ Yang, Y.	+	Structural Characterization of Competence-Stimulating Peptide Analogues Reveals Key Features for ComD1 and ComD2 Receptor Binding in Streptococcus pneumoniae.,Yang Y, Cornilescu G, Tal-Gan Y Biochemistry. 2018 Aug 28. doi: 10.1021/acs.biochem.8b00653. PMID:30125091<ref>PMID:30125091</ref>

-	~~Description: CSP2-E1Ad10~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 6cou" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Yang, Y]]		[[Category: Yang, Y]]
		+	[[Category: Csp]]
		+	[[Category: Pneumococcus]]
		+	[[Category: Quorum sensing]]
		+	[[Category: Signaling molecule]]
		+	[[Category: Signaling protein]]

OCA at 05:46, 25 July 2018

OCA — Wed, 25 Jul 2018 05:46:36 GMT

←Older revision		Revision as of 05:46, 25 July 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6cou is ON HOLD	+	The entry 6cou is ON HOLD until Paper Publication

	Authors: Yang, Y.		Authors: Yang, Y.

OCA: Protected "6cou" [edit=sysop:move=sysop]

OCA — Wed, 21 Mar 2018 06:11:17 GMT

Protected "6cou" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:11, 21 March 2018

OCA: New page: '''Unreleased structure''' The entry 6cou is ON HOLD Authors: Yang, Y. Description: CSP2-E1Ad10 Category: Unreleased Structures Category: Yang, Y

OCA — Wed, 21 Mar 2018 06:11:16 GMT

New page: '''Unreleased structure''' The entry 6cou is ON HOLD Authors: Yang, Y. Description: CSP2-E1Ad10 Category: Unreleased Structures Category: Yang, Y

New page

'''Unreleased structure'''

The entry 6cou is ON HOLD

Authors: Yang, Y.

Description: CSP2-E1Ad10
[[Category: Unreleased Structures]]
[[Category: Yang, Y]]