6cuh - Revision history

OCA at 15:11, 4 October 2023

OCA — Wed, 04 Oct 2023 15:11:23 GMT

←Older revision		Revision as of 15:11, 4 October 2023
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	<StructureSection load='6cuh' size='340' side='right'caption='[[6cuh]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='6cuh' size='340' side='right'caption='[[6cuh]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6cuh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CUH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6CUH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6cuh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CUH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.01Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6cug\|6cug]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6cuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cuh OCA], [~~http~~://pdbe.org/6cuh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6cuh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6cuh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6cuh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cuh OCA], [https://pdbe.org/6cuh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cuh RCSB], [https://www.ebi.ac.uk/pdbsum/6cuh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cuh ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Rossjohn, J]]	+	[[Category: Rossjohn J]]
-	[[Category: Shahine~~, A E]]~~	+	[[Category: Shahine AE]]
-	~~[[Category: Bc8b]]~~	+
-	~~[[Category: Cd1b]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Pc]]~~	+
-	~~[[Category: Phosphatidylcholine]]~~	+
-	~~[[Category: T cell receptor]]~~	+
-	~~[[Category: Tcr~~]]	+

OCA at 09:01, 11 November 2020

OCA — Wed, 11 Nov 2020 09:01:10 GMT

←Older revision		Revision as of 09:01, 11 November 2020
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	==Crystal structure of the unliganded BC8B TCR==		==Crystal structure of the unliganded BC8B TCR==
-	<StructureSection load='6cuh' size='340' side='right' caption='[[6cuh]], [[Resolution\|resolution]] 2.01Å' scene=''>	+	<StructureSection load='6cuh' size='340' side='right'caption='[[6cuh]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6cuh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CUH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6CUH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6cuh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CUH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6CUH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6cug\|6cug]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6cug\|6cug]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6cuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cuh OCA], [http://pdbe.org/6cuh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cuh RCSB], [http://www.ebi.ac.uk/pdbsum/6cuh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cuh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6cuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cuh OCA], [http://pdbe.org/6cuh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cuh RCSB], [http://www.ebi.ac.uk/pdbsum/6cuh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cuh ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 6cuh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6cuh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[T-cell receptor 3D structures\|T-cell receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Rossjohn, J]]		[[Category: Rossjohn, J]]
	[[Category: Shahine, A E]]		[[Category: Shahine, A E]]

OCA at 12:05, 16 January 2019

OCA — Wed, 16 Jan 2019 12:05:11 GMT

←Older revision		Revision as of 12:05, 16 January 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6cuh is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the unliganded BC8B TCR==
		+	<StructureSection load='6cuh' size='340' side='right' caption='[[6cuh]], [[Resolution\|resolution]] 2.01Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6cuh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CUH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CUH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6cug\|6cug]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cuh OCA], [http://pdbe.org/6cuh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cuh RCSB], [http://www.ebi.ac.uk/pdbsum/6cuh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cuh ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CD1 proteins are expressed on dendritic cells, where they display lipid antigens to T-cell receptors (TCRs). Here we describe T-cell autoreactivity towards ubiquitous human membrane phospholipids presented by CD1b. These T-cells discriminate between two major types of lipids, sphingolipids and phospholipids, but were broadly cross-reactive towards diverse phospholipids including phosphatidylcholine, phosphatidylinositol and phosphatidylethanolamine. The crystal structure of a representative TCR bound to CD1b-phosphatidylcholine provides a molecular mechanism for this promiscuous recognition. We observe a lateral escape channel in the TCR, which shunted phospholipid head groups sideways along the CD1b-TCR interface, without contacting the TCR. Instead the TCR recognition site involved the neck region phosphate that is common to all major self-phospholipids but absent in sphingolipids. Whereas prior studies have focused on foreign lipids or rare self-lipids, we define a new molecular mechanism of promiscuous recognition of common self-phospholipids including those that are known targets in human autoimmune disease.

-	~~Authors~~:	+	A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids.,Shahine A, Reinink P, Reijneveld JF, Gras S, Holzheimer M, Cheng TY, Minnaard AJ, Altman JD, Lenz S, Prandi J, Kubler-Kielb J, Moody DB, Rossjohn J, Van Rhijn I Nat Commun. 2019 Jan 4;10(1):56. doi: 10.1038/s41467-018-07898-0. PMID:30610190<ref>PMID:30610190</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6cuh" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Rossjohn, J]]
		+	[[Category: Shahine, A E]]
		+	[[Category: Bc8b]]
		+	[[Category: Cd1b]]
		+	[[Category: Immune system]]
		+	[[Category: Pc]]
		+	[[Category: Phosphatidylcholine]]
		+	[[Category: T cell receptor]]
		+	[[Category: Tcr]]

OCA at 12:26, 11 April 2018

OCA — Wed, 11 Apr 2018 12:26:32 GMT

←Older revision		Revision as of 12:26, 11 April 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6cuh is ON HOLD	+	The entry 6cuh is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6cuh" [edit=sysop:move=sysop]

OCA — Wed, 04 Apr 2018 04:42:21 GMT

Protected "6cuh" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:42, 4 April 2018

OCA: New page: '''Unreleased structure''' The entry 6cuh is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 04 Apr 2018 04:42:20 GMT

New page: '''Unreleased structure''' The entry 6cuh is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6cuh is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]