6cxs - Revision history

OCA at 15:13, 4 October 2023

OCA — Wed, 04 Oct 2023 15:13:25 GMT

←Older revision		Revision as of 15:13, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='6cxs' size='340' side='right'caption='[[6cxs]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='6cxs' size='340' side='right'caption='[[6cxs]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6cxs]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Clope Clope~~] and [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CXS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6CXS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6cxs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens_str._13 Clostridium perfringens str. 13] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CXS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FJV:4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4,5 4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine'>FJV</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jkm\|4jkm]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FJV:4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4,5 4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine'>FJV</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bglR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=195102 CLOPE]), malE, b4034, JW3994 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cxs OCA], [https://pdbe.org/6cxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cxs RCSB], [https://www.ebi.ac.uk/pdbsum/6cxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cxs ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6cxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cxs OCA], [~~http~~://pdbe.org/6cxs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6cxs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6cxs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6cxs ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~MALE_ECOLI MALE_ECOLI~~]~~] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.~~	+	[https://www.uniprot.org/uniprot/Q8XP19_CLOPE Q8XP19_CLOPE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Clope~~]]	+	[[Category: Clostridium perfringens str. 13]]
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Redinbo~~, M R~~]]	+	[[Category: Redinbo MR]]
-	[[Category: Wallace~~, B D]]~~	+	[[Category: Wallace BD]]
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Hydrolase-hydrolase-inhibitor complex~~]]	+

OCA at 10:28, 27 March 2020

OCA — Fri, 27 Mar 2020 10:28:59 GMT

←Older revision		Revision as of 10:28, 27 March 2020
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.		[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Irinotecan treats a range of solid tumors, but its effectiveness is severely limited by gastrointestinal (GI) tract toxicity caused by gut bacterial beta-glucuronidase (GUS) enzymes. Targeted bacterial GUS inhibitors have been shown to partially alleviate irinotecan-induced GI tract damage and resultant diarrhea in mice. Here, we unravel the mechanistic basis for GI protection by gut microbial GUS inhibitors using in vivo models. We use in vitro, in fimo, and in vivo models to determine whether GUS inhibition alters the anticancer efficacy of irinotecan. We demonstrate that a single dose of irinotecan increases GI bacterial GUS activity in 1 d and reduces intestinal epithelial cell proliferation in 5 d, both blocked by a single dose of a GUS inhibitor. In a tumor xenograft model, GUS inhibition prevents intestinal toxicity and maintains the antitumor efficacy of irinotecan. Remarkably, GUS inhibitor also effectively blocks the striking irinotecan-induced bloom of Enterobacteriaceae in immune-deficient mice. In a genetically engineered mouse model of cancer, GUS inhibition alleviates gut damage, improves survival, and does not alter gut microbial composition; however, by allowing dose intensification, it dramatically improves irinotecan's effectiveness, reducing tumors to a fraction of that achieved by irinotecan alone, while simultaneously promoting epithelial regeneration. These results indicate that targeted gut microbial enzyme inhibitors can improve cancer chemotherapeutic outcomes by protecting the gut epithelium from microbial dysbiosis and proliferative crypt damage.
		+
		+	Targeted inhibition of gut bacterial beta-glucuronidase activity enhances anticancer drug efficacy.,Bhatt AP, Pellock SJ, Biernat KA, Walton WG, Wallace BD, Creekmore BC, Letertre MM, Swann JR, Wilson ID, Roques JR, Darr DB, Bailey ST, Montgomery SA, Roach JM, Azcarate-Peril MA, Sartor RB, Gharaibeh RZ, Bultman SJ, Redinbo MR Proc Natl Acad Sci U S A. 2020 Mar 13. pii: 1918095117. doi:, 10.1073/pnas.1918095117. PMID:32170007<ref>PMID:32170007</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6cxs" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Glucuronisidase 3D structures\|Glucuronisidase 3D structures]]		*[[Glucuronisidase 3D structures\|Glucuronisidase 3D structures]]
	*[[Maltose-binding protein 3D structures\|Maltose-binding protein 3D structures]]		*[[Maltose-binding protein 3D structures\|Maltose-binding protein 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:49, 11 March 2020

OCA — Wed, 11 Mar 2020 07:49:39 GMT

←Older revision		Revision as of 07:49, 11 March 2020
Line 3:		Line 3:
	<StructureSection load='6cxs' size='340' side='right'caption='[[6cxs]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='6cxs' size='340' side='right'caption='[[6cxs]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6cxs]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CXS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6cxs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Clope Clope] and [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CXS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FJV:4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4,5 4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine'>FJV</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FJV:4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4,5 4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine'>FJV</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jkm\|4jkm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jkm\|4jkm]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bglR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=195102 CLOPE]), malE, b4034, JW3994 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cxs OCA], [http://pdbe.org/6cxs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cxs RCSB], [http://www.ebi.ac.uk/pdbsum/6cxs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cxs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cxs OCA], [http://pdbe.org/6cxs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cxs RCSB], [http://www.ebi.ac.uk/pdbsum/6cxs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cxs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.		[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
		+
		+	==See Also==
		+	*[[Glucuronisidase 3D structures\|Glucuronisidase 3D structures]]
		+	*[[Maltose-binding protein 3D structures\|Maltose-binding protein 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Clope]]
		+	[[Category: Ecoli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Redinbo, M R]]		[[Category: Redinbo, M R]]

OCA at 05:50, 17 April 2019

OCA — Wed, 17 Apr 2019 05:50:56 GMT

←Older revision		Revision as of 05:50, 17 April 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6cxs is ~~ON HOLD until Paper Publication~~	+	==Crystal Structure of Clostridium perfringens beta-glucuronidase bound with a novel, potent inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine==
-		+	<StructureSection load='6cxs' size='340' side='right'caption='[[6cxs]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6cxs]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CXS FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FJV:4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4,5 4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine'>FJV</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jkm\|4jkm]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cxs OCA], [http://pdbe.org/6cxs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cxs RCSB], [http://www.ebi.ac.uk/pdbsum/6cxs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cxs ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Redinbo, M R]]
		+	[[Category: Wallace, B D]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Hydrolase-hydrolase-inhibitor complex]]

OCA at 05:46, 25 July 2018

OCA — Wed, 25 Jul 2018 05:46:48 GMT

←Older revision		Revision as of 05:46, 25 July 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6cxs is ON HOLD	+	The entry 6cxs is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6cxs" [edit=sysop:move=sysop]

OCA — Wed, 11 Apr 2018 12:33:12 GMT

Protected "6cxs" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:33, 11 April 2018

OCA: New page: '''Unreleased structure''' The entry 6cxs is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 11 Apr 2018 12:33:11 GMT

New page: '''Unreleased structure''' The entry 6cxs is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6cxs is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]