6cyq - Revision history

OCA at 15:13, 4 October 2023

OCA — Wed, 04 Oct 2023 15:13:56 GMT

←Older revision		Revision as of 15:13, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='6cyq' size='340' side='right'caption='[[6cyq]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='6cyq' size='340' side='right'caption='[[6cyq]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6cyq]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CYQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6cyq]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CYQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CE4:(2R)-2-[(R)-{[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ACETYL]AMINO}(CARBOXY)METHYL]-5-METHYLIDENE-5,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC+ACID'>CE4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.698Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6cyn\|6cyn]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CE4:(2R)-2-[(R)-{[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ACETYL]AMINO}(CARBOXY)METHYL]-5-METHYLIDENE-5,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC+ACID'>CE4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaCTX-M-14, beta-lactamase CTX-M-14, bla-CTX-M-14a, blaCTX-M-14a, blaCTX-M-14b, blaCTX-M-14c, blaCTX-M-27b, blatoho-3, blaUOE-2, CTX-M-14, AM333_26030, APT94_14605, BET08_34355, BJJ90_27545, BK334_27290, BMR21_24310, BMR35_25520, BMR49_25760, BXT93_06855, CA268_29135, CDL37_21060, CR538_26855, ETN48_p0088, pCT_085, pHK01_011 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cyq OCA], [https://pdbe.org/6cyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cyq RCSB], [https://www.ebi.ac.uk/pdbsum/6cyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cyq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cyq OCA], [https://pdbe.org/6cyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cyq RCSB], [https://www.ebi.ac.uk/pdbsum/6cyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cyq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9L5C8_ECOLX Q9L5C8_ECOLX]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895]]~~	+	[[Category: Escherichia coli]]
-	~~[[Category: Beta-lactamase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brown, C]]	+	[[Category: Brown C]]
-	[[Category: Hu, L]]	+	[[Category: Hu L]]
-	[[Category: Palzkill, T]]	+	[[Category: Palzkill T]]
-	[[Category: Patel~~, M P~~]]	+	[[Category: Patel MP]]
-	[[Category: Prasad~~, B V.V~~]]	+	[[Category: Prasad BVV]]
-	[[Category: Sankaran, B]]	+	[[Category: Sankaran B]]
-	~~[[Category: Beta-lactamase ctx-m-14]]~~	+
-	~~[[Category: Hydrolase-antibiotic complex~~]]	+

OCA at 03:41, 2 July 2021

OCA — Fri, 02 Jul 2021 03:41:03 GMT

←Older revision		Revision as of 03:41, 2 July 2021
Line 3:		Line 3:
	<StructureSection load='6cyq' size='340' side='right'caption='[[6cyq]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='6cyq' size='340' side='right'caption='[[6cyq]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6cyq]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CYQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6CYQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6cyq]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CYQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CE4:(2R)-2-[(R)-{[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ACETYL]AMINO}(CARBOXY)METHYL]-5-METHYLIDENE-5,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC+ACID'>CE4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CE4:(2R)-2-[(R)-{[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ACETYL]AMINO}(CARBOXY)METHYL]-5-METHYLIDENE-5,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC+ACID'>CE4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6cyn\|6cyn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6cyn\|6cyn]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaCTX-M-14, beta-lactamase CTX-M-14, bla-CTX-M-14a, blaCTX-M-14a, blaCTX-M-14b, blaCTX-M-14c, blaCTX-M-27b, blatoho-3, blaUOE-2, CTX-M-14, AM333_26030, APT94_14605, BET08_34355, BJJ90_27545, BK334_27290, BMR21_24310, BMR35_25520, BMR49_25760, BXT93_06855, CA268_29135, CDL37_21060, CR538_26855, ETN48_p0088, pCT_085, pHK01_011 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaCTX-M-14, beta-lactamase CTX-M-14, bla-CTX-M-14a, blaCTX-M-14a, blaCTX-M-14b, blaCTX-M-14c, blaCTX-M-27b, blatoho-3, blaUOE-2, CTX-M-14, AM333_26030, APT94_14605, BET08_34355, BJJ90_27545, BK334_27290, BMR21_24310, BMR35_25520, BMR49_25760, BXT93_06855, CA268_29135, CDL37_21060, CR538_26855, ETN48_p0088, pCT_085, pHK01_011 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6cyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cyq OCA], [~~http~~://pdbe.org/6cyq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6cyq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6cyq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6cyq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cyq OCA], [https://pdbe.org/6cyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cyq RCSB], [https://www.ebi.ac.uk/pdbsum/6cyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cyq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 34:		Line 34:
	[[Category: Patel, M P]]		[[Category: Patel, M P]]
	[[Category: Prasad, B V.V]]		[[Category: Prasad, B V.V]]
		+	[[Category: Sankaran, B]]
	[[Category: Beta-lactamase ctx-m-14]]		[[Category: Beta-lactamase ctx-m-14]]
	[[Category: Hydrolase-antibiotic complex]]		[[Category: Hydrolase-antibiotic complex]]

OCA at 09:53, 18 December 2019

OCA — Wed, 18 Dec 2019 09:53:52 GMT

←Older revision		Revision as of 09:53, 18 December 2019
Line 1:		Line 1:

	==Crystal structure of CTX-M-14 S70G/N106S beta-lactamase in complex with hydrolyzed cefotaxime==		==Crystal structure of CTX-M-14 S70G/N106S beta-lactamase in complex with hydrolyzed cefotaxime==
-	<StructureSection load='6cyq' size='340' side='right' caption='[[6cyq]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='6cyq' size='340' side='right'caption='[[6cyq]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6cyq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CYQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[6cyq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CYQ FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6cyq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6cyq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
		+	[[Category: Large Structures]]
	[[Category: Brown, C]]		[[Category: Brown, C]]
	[[Category: Hu, L]]		[[Category: Hu, L]]

OCA at 08:34, 17 October 2018

OCA — Wed, 17 Oct 2018 08:34:55 GMT

←Older revision		Revision as of 08:34, 17 October 2018
Line 3:		Line 3:
	<StructureSection load='6cyq' size='340' side='right' caption='[[6cyq]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='6cyq' size='340' side='right' caption='[[6cyq]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6cyq]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CYQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6cyq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CYQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CE4:(2R)-2-[(R)-{[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ACETYL]AMINO}(CARBOXY)METHYL]-5-METHYLIDENE-5,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC+ACID'>CE4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CE4:(2R)-2-[(R)-{[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ACETYL]AMINO}(CARBOXY)METHYL]-5-METHYLIDENE-5,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC+ACID'>CE4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6cyn\|6cyn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6cyn\|6cyn]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaCTX-M-14, beta-lactamase CTX-M-14, bla-CTX-M-14a, blaCTX-M-14a, blaCTX-M-14b, blaCTX-M-14c, blaCTX-M-27b, blatoho-3, blaUOE-2, CTX-M-14, AM333_26030, APT94_14605, BET08_34355, BJJ90_27545, BK334_27290, BMR21_24310, BMR35_25520, BMR49_25760, BXT93_06855, CA268_29135, CDL37_21060, CR538_26855, ETN48_p0088, pCT_085, pHK01_011 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cyq OCA], [http://pdbe.org/6cyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cyq RCSB], [http://www.ebi.ac.uk/pdbsum/6cyq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cyq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cyq OCA], [http://pdbe.org/6cyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cyq RCSB], [http://www.ebi.ac.uk/pdbsum/6cyq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cyq ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The CTX-M beta-lactamases have emerged as the most widespread extended-spectrum beta-lactamases (ESBLs) in Gram-negative bacteria. These enzymes rapidly hydrolyze cefotaxime, but not the related cephalosporin, ceftazidime. ESBL variants have evolved, however, that provide enhanced ceftazidime resistance. We show here that a natural variant at a non-active site, second-shell residue, N106S, enhances enzyme stability, but reduces catalytic efficiency for cefotaxime and ceftazidime and decreases resistance levels. However, when the N106S variant was combined with an active-site variant, D240G, that enhances enzyme catalytic efficiency, but decreases stability, the resultant double mutant exhibited higher resistance levels than predicted on the basis of the phenotypes of each variant. We found that this epistasis is due to compensatory effects, whereby increased stability provided by N106S overrides its cost of decreased catalytic activity. X-ray structures of the variant enzymes in complex with cefotaxime revealed conformational changes in the active site loop spanning residues 103-106 that were caused by the N106S substitution and relieve steric strain to stabilize the enzyme, but also alter contacts with cefotaxime and thereby reduce catalytic activity. We noted that the 103-106 loop conformation in the N106S-containing variants is different from that of wild-type CTX-M, but nearly identical to that of the non-ESBL, TEM-1 beta-lactamase, having a serine at the 106 position. Therefore, residue 106 may serve as a "switch" that toggles the conformations of the 103-106 loop. When it is serine, the loop is in the non-ESBL, TEM-like conformation, and when it is asparagine, the loop is in a CTX-M-like, cefotaximase-favorable conformation.
		+
		+	Synergistic effects of functionally distinct substitutions in beta-lactamase variants shed light on the evolution of bacterial drug resistance.,Patel MP, Hu L, Brown CA, Sun Z, Adamski CJ, Stojanoski V, Sankaran B, Prasad BVV, Palzkill T J Biol Chem. 2018 Oct 1. pii: RA118.003792. doi: 10.1074/jbc.RA118.003792. PMID:30275013<ref>PMID:30275013</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6cyq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Brown, C]]		[[Category: Brown, C]]

OCA at 08:05, 10 October 2018

OCA — Wed, 10 Oct 2018 08:05:57 GMT

←Older revision		Revision as of 08:05, 10 October 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6cyq ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of CTX-M-14 S70G/N106S beta-lactamase in complex with hydrolyzed cefotaxime==
-		+	<StructureSection load='6cyq' size='340' side='right' caption='[[6cyq]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~Authors~~: ~~Patel, M~~.P., Hu, L., ~~Brown~~, C., ~~Prasad~~, B.V.V., ~~Palzkill~~, T.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6cyq]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CYQ FirstGlance]. <br>
-	~~Description: Crystal structure of CTX-M-14 S70G~~/~~N106S beta-lactamase in complex with hydrolyzed cefotaxime~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CE4:(2R)-2-[(R)-{[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ACETYL]AMINO}(CARBOXY)METHYL]-5-METHYLIDENE-5,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC+ACID'>CE4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6cyn\|6cyn]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cyq OCA], [http://pdbe.org/6cyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cyq RCSB], [http://www.ebi.ac.uk/pdbsum/6cyq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cyq ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Beta-lactamase]]
	[[Category: Brown, C]]		[[Category: Brown, C]]
	[[Category: Hu, L]]		[[Category: Hu, L]]
-	[[Category: Patel, M.P]]
-	[[Category: Prasad, B.V.V]]
	[[Category: Palzkill, T]]		[[Category: Palzkill, T]]
		+	[[Category: Patel, M P]]
		+	[[Category: Prasad, B V.V]]
		+	[[Category: Beta-lactamase ctx-m-14]]
		+	[[Category: Hydrolase-antibiotic complex]]

OCA: Protected "6cyq" [edit=sysop:move=sysop]

OCA — Wed, 18 Apr 2018 04:13:26 GMT

Protected "6cyq" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:13, 18 April 2018

OCA: New page: '''Unreleased structure''' The entry 6cyq is ON HOLD until Paper Publication Authors: Patel, M.P., Hu, L., Brown, C., Prasad, B.V.V., Palzkill, T. Description: Crystal structure of CTX...

OCA — Wed, 18 Apr 2018 04:13:25 GMT

New page: '''Unreleased structure''' The entry 6cyq is ON HOLD until Paper Publication Authors: Patel, M.P., Hu, L., Brown, C., Prasad, B.V.V., Palzkill, T. Description: Crystal structure of CTX...

New page

'''Unreleased structure'''

The entry 6cyq is ON HOLD until Paper Publication

Authors: Patel, M.P., Hu, L., Brown, C., Prasad, B.V.V., Palzkill, T.

Description: Crystal structure of CTX-M-14 S70G/N106S beta-lactamase in complex with hydrolyzed cefotaxime
[[Category: Unreleased Structures]]
[[Category: Brown, C]]
[[Category: Hu, L]]
[[Category: Patel, M.P]]
[[Category: Prasad, B.V.V]]
[[Category: Palzkill, T]]