6d0j - Revision history

OCA at 15:15, 4 October 2023

OCA — Wed, 04 Oct 2023 15:15:17 GMT

←Older revision		Revision as of 15:15, 4 October 2023
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	<StructureSection load='6d0j' size='340' side='right'caption='[[6d0j]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='6d0j' size='340' side='right'caption='[[6d0j]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6d0j]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Entcs Entcs~~] and [~~http~~://en.wikipedia.org/wiki/~~Synthetic_construct_sequences~~ Synthetic construct ~~sequences~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D0J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6D0J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6d0j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_casseliflavus_EC10 Enterococcus casseliflavus EC10] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D0J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=MHA:(CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC+ACID'>MHA</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECAG_02710 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=565654 ENTCS])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=MHA:(CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC+ACID'>MHA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6d0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d0j OCA], [~~http~~://pdbe.org/6d0j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6d0j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6d0j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6d0j ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d0j OCA], [https://pdbe.org/6d0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d0j RCSB], [https://www.ebi.ac.uk/pdbsum/6d0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d0j ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/C9CPP6_ENTCS C9CPP6_ENTCS]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Entcs~~]]	+	[[Category: Enterococcus casseliflavus EC10]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Synthetic construct ~~sequences~~]]	+	[[Category: Synthetic construct]]
-	[[Category: Koide, A]]	+	[[Category: Koide A]]
-	[[Category: Koide, S]]	+	[[Category: Koide S]]
-	[[Category: Kolmakova-Partensky, L]]	+	[[Category: Kolmakova-Partensky L]]
-	[[Category: Last~~, N B~~]]	+	[[Category: Last NB]]
-	[[Category: Miller, C]]	+	[[Category: Miller C]]
-	[[Category: Shane, T]]	+	[[Category: Shane T]]
-	[[Category: Stockbridge~~, R B~~]]	+	[[Category: Stockbridge RB]]
-	[[Category: Wilson~~, A E]]~~	+	[[Category: Wilson AE]]
-	~~[[Category: Fluoride/proton antiporter clc membrane protein]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 10:54, 1 January 2020

OCA — Wed, 01 Jan 2020 10:54:37 GMT

←Older revision		Revision as of 10:54, 1 January 2020
Line 1:		Line 1:

	==Crystal structure of a CLC-type fluoride/proton antiporter==		==Crystal structure of a CLC-type fluoride/proton antiporter==
-	<StructureSection load='6d0j' size='340' side='right' caption='[[6d0j]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='6d0j' size='340' side='right'caption='[[6d0j]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6d0j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Entcs Entcs] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D0J FirstGlance]. <br>		<table><tr><td colspan='2'>[[6d0j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Entcs Entcs] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D0J FirstGlance]. <br>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Entcs]]		[[Category: Entcs]]
		+	[[Category: Large Structures]]
	[[Category: Synthetic construct sequences]]		[[Category: Synthetic construct sequences]]
	[[Category: Koide, A]]		[[Category: Koide, A]]

OCA at 06:15, 11 July 2018

OCA — Wed, 11 Jul 2018 06:15:37 GMT

←Older revision		Revision as of 06:15, 11 July 2018
Line 3:		Line 3:
	<StructureSection load='6d0j' size='340' side='right' caption='[[6d0j]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='6d0j' size='340' side='right' caption='[[6d0j]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6d0j]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D0J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6d0j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Entcs Entcs] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D0J FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=MHA:(CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC+ACID'>MHA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=MHA:(CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC+ACID'>MHA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECAG_02710 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=565654 ENTCS])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d0j OCA], [http://pdbe.org/6d0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d0j RCSB], [http://www.ebi.ac.uk/pdbsum/6d0j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d0j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d0j OCA], [http://pdbe.org/6d0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d0j RCSB], [http://www.ebi.ac.uk/pdbsum/6d0j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d0j ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fluoride/proton antiporters of the CLC(F) family combat F(-) toxicity in bacteria by exporting this halide from the cytoplasm. These transporters belong to the widespread CLC superfamily but display transport properties different from those of the well-studied Cl(-)/H(+) antiporters. Here, we report a structural and functional investigation of these F(-)-transport proteins. Crystal structures of a CLC(F) homolog from Enterococcus casseliflavus are captured in two conformations with simultaneous accessibility of F(-) and H(+) ions via separate pathways on opposite sides of the membrane. Manipulation of a key glutamate residue critical for H(+) and F(-) transport reverses the anion selectivity of transport; replacement of the glutamate with glutamine or alanine completely inhibits F(-) and H(+) transport while allowing for rapid uncoupled flux of Cl(-). The structural and functional results lead to a 'windmill' model of CLC antiport wherein F (-) and H(+) simultaneously move through separate ion-specific pathways that switch sidedness during the transport cycle.
		+
		+	A CLC-type F(-)/H(+) antiporter in ion-swapped conformations.,Last NB, Stockbridge RB, Wilson AE, Shane T, Kolmakova-Partensky L, Koide A, Koide S, Miller C Nat Struct Mol Biol. 2018 Jun 25. pii: 10.1038/s41594-018-0082-0. doi:, 10.1038/s41594-018-0082-0. PMID:29941917<ref>PMID:29941917</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6d0j" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Entcs]]
		+	[[Category: Synthetic construct sequences]]
	[[Category: Koide, A]]		[[Category: Koide, A]]
	[[Category: Koide, S]]		[[Category: Koide, S]]

OCA at 07:14, 4 July 2018

OCA — Wed, 04 Jul 2018 07:14:41 GMT

←Older revision		Revision as of 07:14, 4 July 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6d0j is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of a CLC-type fluoride/proton antiporter==
-		+	<StructureSection load='6d0j' size='340' side='right' caption='[[6d0j]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6d0j]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D0J FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=MHA:(CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC+ACID'>MHA</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d0j OCA], [http://pdbe.org/6d0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d0j RCSB], [http://www.ebi.ac.uk/pdbsum/6d0j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d0j ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Koide, A]]
		+	[[Category: Koide, S]]
		+	[[Category: Kolmakova-Partensky, L]]
		+	[[Category: Last, N B]]
		+	[[Category: Miller, C]]
		+	[[Category: Shane, T]]
		+	[[Category: Stockbridge, R B]]
		+	[[Category: Wilson, A E]]
		+	[[Category: Fluoride/proton antiporter clc membrane protein]]
		+	[[Category: Transport protein]]

OCA: Protected "6d0j" [edit=sysop:move=sysop]

OCA — Wed, 18 Apr 2018 04:18:30 GMT

Protected "6d0j" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:18, 18 April 2018

OCA: New page: '''Unreleased structure''' The entry 6d0j is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 18 Apr 2018 04:18:28 GMT

New page: '''Unreleased structure''' The entry 6d0j is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6d0j is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]