6d3t - Revision history

OCA at 10:41, 14 June 2023

OCA — Wed, 14 Jun 2023 10:41:40 GMT

←Older revision		Revision as of 10:41, 14 June 2023
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	==NMR solution structure of tamapin, mutant DP30==		==NMR solution structure of tamapin, mutant DP30==
-	<StructureSection load='6d3t' size='340' side='right'caption='[[6d3t~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='6d3t' size='340' side='right'caption='[[6d3t]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6d3t]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buthus_tamalus Buthus tamalus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D3T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6D3T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6d3t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_tamulus Mesobuthus tamulus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D3T FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6d3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d3t OCA], [~~http~~://pdbe.org/6d3t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6d3t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6d3t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6d3t ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d3t OCA], [https://pdbe.org/6d3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d3t RCSB], [https://www.ebi.ac.uk/pdbsum/6d3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d3t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~KAX54_MESTA KAX54_MESTA]~~] Blocks small conductance calcium-activated potassium channels ~~in pyramidal neurons of the hippocampus~~. ~~Displays a unique, remarkable selectivity for SK2~~/KCNN2 ~~versus SK1~~/KCNN1 and ~~SK3~~/~~KCNN3 channels~~.<ref>PMID:12239213</ref>	+	[https://www.uniprot.org/uniprot/KAX54_HOTTA KAX54_HOTTA] Blocks small conductance calcium-activated potassium channels (PubMed:12239213). Shows activity on KCa2.2/KCNN2 (IC(50)=0.0243 nM), KCa2.3/KCNN3 (IC(50)=1.7 nM), and KCa2.1/KCNN1 (IC(50)=42 nM) (PubMed:12239213). Induces cell death when tested on Jurkat E6-1 and human mammary breast cancer MDA-MB-231 which constituvely express KCa2.2/KCNN2, but not on human peripheral blood lymphocytes (which do not express KCa2.2/KCNN2) (PubMed:24821061).<ref>PMID:12239213</ref>

	==See Also==		==See Also==
Line 15:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buthus tamalus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Delgado, G Titaux~~]]	+	[[Category: Mesobuthus tamulus]]
-	[[Category: Flores, M ~~Mayorga~~]]	+	[[Category: Mayorga Flores M]]
-	[[Category: Meneses~~, C M.Melchor~~]]	+	[[Category: Melchor Meneses CM]]
-	[[Category: ~~Portilla, F del Rio~~]]	+	[[Category: Titaux Delgado G]]
-	[[Category: ~~Cs-alpha/beta]]~~	+	[[Category: Del Rio Portilla F]]
-	~~[[Category: Dp30]]~~	+
-	~~[[Category: Sk channel]]~~	+
-	~~[[Category: Tamapin mutant]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 11:18, 29 July 2020

OCA — Wed, 29 Jul 2020 11:18:22 GMT

←Older revision		Revision as of 11:18, 29 July 2020
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	<StructureSection load='6d3t' size='340' side='right'caption='[[6d3t]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='6d3t' size='340' side='right'caption='[[6d3t]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6d3t]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D3T OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6D3T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6d3t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buthus_tamalus Buthus tamalus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D3T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6D3T FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6d3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d3t OCA], [http://pdbe.org/6d3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d3t RCSB], [http://www.ebi.ac.uk/pdbsum/6d3t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d3t ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6d3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d3t OCA], [http://pdbe.org/6d3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d3t RCSB], [http://www.ebi.ac.uk/pdbsum/6d3t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d3t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/KAX54_MESTA KAX54_MESTA]] Blocks small conductance calcium-activated potassium channels in pyramidal neurons of the hippocampus. Displays a unique, remarkable selectivity for SK2/KCNN2 versus SK1/KCNN1 and SK3/KCNN3 channels.<ref>PMID:12239213</ref>		[[http://www.uniprot.org/uniprot/KAX54_MESTA KAX54_MESTA]] Blocks small conductance calcium-activated potassium channels in pyramidal neurons of the hippocampus. Displays a unique, remarkable selectivity for SK2/KCNN2 versus SK1/KCNN1 and SK3/KCNN3 channels.<ref>PMID:12239213</ref>
		+
		+	==See Also==
		+	*[[Potassium channel toxin 3D structures\|Potassium channel toxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buthus tamalus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Delgado, G Titaux]]		[[Category: Delgado, G Titaux]]

OCA at 10:36, 17 July 2019

OCA — Wed, 17 Jul 2019 10:36:11 GMT

←Older revision		Revision as of 10:36, 17 July 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6d3t is ~~ON HOLD~~ ~~until Paper Publication~~	+	==NMR solution structure of tamapin, mutant DP30==
-		+	<StructureSection load='6d3t' size='340' side='right'caption='[[6d3t]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6d3t]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D3T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D3T FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d3t OCA], [http://pdbe.org/6d3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d3t RCSB], [http://www.ebi.ac.uk/pdbsum/6d3t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d3t ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KAX54_MESTA KAX54_MESTA]] Blocks small conductance calcium-activated potassium channels in pyramidal neurons of the hippocampus. Displays a unique, remarkable selectivity for SK2/KCNN2 versus SK1/KCNN1 and SK3/KCNN3 channels.<ref>PMID:12239213</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Delgado, G Titaux]]
		+	[[Category: Flores, M Mayorga]]
		+	[[Category: Meneses, C M.Melchor]]
		+	[[Category: Portilla, F del Rio]]
		+	[[Category: Cs-alpha/beta]]
		+	[[Category: Dp30]]
		+	[[Category: Sk channel]]
		+	[[Category: Tamapin mutant]]
		+	[[Category: Toxin]]

OCA at 04:49, 9 May 2018

OCA — Wed, 09 May 2018 04:49:40 GMT

←Older revision		Revision as of 04:49, 9 May 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6d3t is ON HOLD	+	The entry 6d3t is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6d3t" [edit=sysop:move=sysop]

OCA — Wed, 25 Apr 2018 04:10:08 GMT

Protected "6d3t" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:10, 25 April 2018

OCA: New page: '''Unreleased structure''' The entry 6d3t is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 25 Apr 2018 04:10:06 GMT

New page: '''Unreleased structure''' The entry 6d3t is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6d3t is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]