6d4i - Revision history

OCA at 15:17, 4 October 2023

OCA — Wed, 04 Oct 2023 15:17:58 GMT

←Older revision		Revision as of 15:17, 4 October 2023
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	<StructureSection load='6d4i' size='340' side='right'caption='[[6d4i]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='6d4i' size='340' side='right'caption='[[6d4i]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6d4i]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Macmu Macmu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D4I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6D4I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6d4i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D4I FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.95Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3haf\|3haf]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6d4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d4i OCA], [~~http~~://pdbe.org/6d4i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6d4i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6d4i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6d4i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d4i OCA], [https://pdbe.org/6d4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d4i RCSB], [https://www.ebi.ac.uk/pdbsum/6d4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d4i ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/F7H602_MACMU F7H602_MACMU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6d4i" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6d4i" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Macmu~~]]	+	[[Category: Macaca mulatta]]
-	[[Category: Gohain, N]]	+	[[Category: Gohain N]]
-	[[Category: Pazgier, M]]	+	[[Category: Pazgier M]]
-	[[Category: Tolbert~~, W D]]~~	+	[[Category: Tolbert WD]]
-	~~[[Category: Fc fragment]]~~	+
-	~~[[Category: Igg1]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin]]~~	+
-	~~[[Category: Immunoglobulin-like betasandwich~~]]	+

OCA at 23:00, 5 June 2019

OCA — Wed, 05 Jun 2019 23:00:17 GMT

←Older revision		Revision as of 23:00, 5 June 2019
Line 3:		Line 3:
	<StructureSection load='6d4i' size='340' side='right'caption='[[6d4i]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='6d4i' size='340' side='right'caption='[[6d4i]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6d4i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D4I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6d4i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D4I FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3haf\|3haf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3haf\|3haf]]</td></tr>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Macmu]]
	[[Category: Gohain, N]]		[[Category: Gohain, N]]
	[[Category: Pazgier, M]]		[[Category: Pazgier, M]]

OCA at 08:42, 1 May 2019

OCA — Wed, 01 May 2019 08:42:48 GMT

←Older revision		Revision as of 08:42, 1 May 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6d4i is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure of a Fc Fragment of Rhesus macaque (Macaca mulatta) IgG2==
		+	<StructureSection load='6d4i' size='340' side='right'caption='[[6d4i]], [[Resolution\|resolution]] 2.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6d4i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D4I FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3haf\|3haf]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d4i OCA], [http://pdbe.org/6d4i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d4i RCSB], [http://www.ebi.ac.uk/pdbsum/6d4i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d4i ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Old World monkey, Rhesus macaque (Macaca mulatta, Mm), is frequently used as a primate model organism in the study of human disease and to test new vaccines/antibody treatments despite diverging before chimpanzees and orangutans. Mm and humans share 93% genome identity with substantial differences in the genes of the adaptive immune system that lead to different functional IgG subclass characteristics, Fcgamma receptors expressed on innate immune cells, and biological interactions. These differences put limitations on Mm use as a primary animal model in the study of human disease and to test new vaccines/antibody treatments. Here, we comprehensively analyzed molecular properties of the Fc domain of the four IgG subclasses of Rhesus macaque to describe potential mechanisms for their interactions with effector cell Fc receptors. Our studies revealed less diversity in the overall structure among the Mm IgG Fc, with MmIgG1 Fc being the most structurally like human IgG3, although its CH2 loops and N(297) glycan mobility are comparable to human IgG1. Furthermore, the Fcs of Mm IgG3 and 4 lack the structural properties typical for their human orthologues that determine IgG3's reduced interaction with the neonatal receptor and IgG4's ability for Fab-arm exchange and its weaker Fcgamma receptor interactions. Taken together, our data indicate that MmIgG1-4 are less structurally divergent than the human IgGs, with only MmIgG1 matching the molecular properties of human IgG1 and 3, the most active IgGs in terms of Fcgamma receptor binding and Fc-mediated functions. PDB accession numbers for deposited structures are 6D4E, 6D4I, 6D4M, and 6D4N for MmIgG1 Fc, MmIgG2 Fc, MmIgG3 Fc, and MmIgG4 Fc, respectively.

-	~~Authors~~: ~~Gohain, N~~., Tolbert, ~~W.D.~~, ~~Pazgier~~, M.	+	From Rhesus macaque to human: structural evolutionary pathways for immunoglobulin G subclasses.,Tolbert WD, Subedi GP, Gohain N, Lewis GK, Patel KR, Barb AW, Pazgier M MAbs. 2019 Apr 2:1-16. doi: 10.1080/19420862.2019.1589852. PMID:30939981<ref>PMID:30939981</ref>

-	~~Description: Crystal Structure of~~ a ~~Fc Fragment~~ of ~~Rhesus macaque (Macaca mulatta) IgG2~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Pazgier, M]]~~	+	<div class="pdbe-citations 6d4i" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Tolbert, W.D~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Gohain, N]]		[[Category: Gohain, N]]
		+	[[Category: Pazgier, M]]
		+	[[Category: Tolbert, W D]]
		+	[[Category: Fc fragment]]
		+	[[Category: Igg1]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin]]
		+	[[Category: Immunoglobulin-like betasandwich]]

OCA at 06:41, 2 May 2018

OCA — Wed, 02 May 2018 06:41:42 GMT

←Older revision		Revision as of 06:41, 2 May 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6d4i is ON HOLD	+	The entry 6d4i is ON HOLD until Paper Publication

	Authors: Gohain, N., Tolbert, W.D., Pazgier, M.		Authors: Gohain, N., Tolbert, W.D., Pazgier, M.

OCA: Protected "6d4i" [edit=sysop:move=sysop]

OCA — Wed, 25 Apr 2018 04:11:45 GMT

Protected "6d4i" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:11, 25 April 2018

OCA: New page: '''Unreleased structure''' The entry 6d4i is ON HOLD Authors: Gohain, N., Tolbert, W.D., Pazgier, M. Description: Crystal Structure of a Fc Fragment of Rhesus macaque (Macaca mulatta) ...

OCA — Wed, 25 Apr 2018 04:11:44 GMT

New page: '''Unreleased structure''' The entry 6d4i is ON HOLD Authors: Gohain, N., Tolbert, W.D., Pazgier, M. Description: Crystal Structure of a Fc Fragment of Rhesus macaque (Macaca mulatta) ...

New page

'''Unreleased structure'''

The entry 6d4i is ON HOLD

Authors: Gohain, N., Tolbert, W.D., Pazgier, M.

Description: Crystal Structure of a Fc Fragment of Rhesus macaque (Macaca mulatta) IgG2
[[Category: Unreleased Structures]]
[[Category: Pazgier, M]]
[[Category: Tolbert, W.D]]
[[Category: Gohain, N]]