6d69 - Revision history

OCA at 15:19, 4 October 2023

OCA — Wed, 04 Oct 2023 15:19:16 GMT

←Older revision		Revision as of 15:19, 4 October 2023
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	<StructureSection load='6d69' size='340' side='right'caption='[[6d69]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='6d69' size='340' side='right'caption='[[6d69]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6d69]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D69 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6D69 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6d69]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D69 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.601Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~tn, abba, CG15105, Dmel_CG15105 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6d69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d69 OCA], [~~http~~://pdbe.org/6d69 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6d69 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6d69 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6d69 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d69 OCA], [https://pdbe.org/6d69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d69 RCSB], [https://www.ebi.ac.uk/pdbsum/6d69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d69 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q7JUV6_DROME Q7JUV6_DROME]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Geisbrecht~~, B V~~]]	+	[[Category: Geisbrecht BV]]
-	[[Category: McWhorter~~, W J~~]]	+	[[Category: McWhorter WJ]]
-	[[Category: Ramyar~~, K X]]~~	+	[[Category: Ramyar KX]]
-	~~[[Category: Beta-propeller]]~~	+
-	~~[[Category: Limb girdle muscular dystrophy type 2h]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Protein-protein interaction~~]]	+

OCA at 06:20, 6 May 2020

OCA — Wed, 06 May 2020 06:20:12 GMT

←Older revision		Revision as of 06:20, 6 May 2020
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	<StructureSection load='6d69' size='340' side='right'caption='[[6d69]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='6d69' size='340' side='right'caption='[[6d69]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6d69]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D69 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6D69 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6d69]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D69 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6D69 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6d69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d69 OCA], [http://pdbe.org/6d69 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d69 RCSB], [http://www.ebi.ac.uk/pdbsum/6d69 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d69 ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tn, abba, CG15105, Dmel_CG15105 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6d69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d69 OCA], [http://pdbe.org/6d69 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d69 RCSB], [http://www.ebi.ac.uk/pdbsum/6d69 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d69 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cell growth and/or proliferation may require the reprogramming of metabolic pathways, whereby a switch from oxidative to glycolytic metabolism diverts glycolytic intermediates towards anabolic pathways. Herein, we identify a novel role for TRIM32 in the maintenance of glycolytic flux mediated by biochemical interactions with the glycolytic enzymes Aldolase and Phosphoglycerate mutase. Loss of Drosophila TRIM32, encoded by thin (tn), shows reduced levels of glycolytic intermediates and amino acids. This altered metabolic profile correlates with a reduction in the size of glycolytic larval muscle and brain tissue. Consistent with a role for metabolic intermediates in glycolysis-driven biomass production, dietary amino acid supplementation in tn mutants improves muscle mass. Remarkably, TRIM32 is also required for ectopic growth - loss of TRIM32 in a wing disc-associated tumor model reduces glycolytic metabolism and restricts growth. Overall, our results reveal a novel role for TRIM32 for controlling glycolysis in the context of both normal development and tumor growth.
		+
		+	Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth.,Bawa S, Brooks DS, Neville KE, Tipping M, Sagar MA, Kollhoff JA, Chawla G, Geisbrecht BV, Tennessen JM, Eliceiri KW, Geisbrecht ER Elife. 2020 Mar 30;9. pii: 52358. doi: 10.7554/eLife.52358. PMID:32223900<ref>PMID:32223900</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6d69" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Drome]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Geisbrecht, B V]]		[[Category: Geisbrecht, B V]]

OCA at 06:37, 24 April 2019

OCA — Wed, 24 Apr 2019 06:37:18 GMT

←Older revision		Revision as of 06:37, 24 April 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6d69 is ~~ON HOLD until Paper Publication~~	+	==Crystal Structure of the NHL Repeat Region of D. melanogaster Thin==
-		+	<StructureSection load='6d69' size='340' side='right'caption='[[6d69]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~Authors~~: ~~Ramyar~~, K.X., ~~McWhorter~~, W.J., ~~Geisbrecht~~, B.V.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6d69]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D69 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D69 FirstGlance]. <br>
-	~~Description: Crystal Structure of the NHL Repeat Region of D. melanogaster Thin~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d69 OCA], [http://pdbe.org/6d69 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d69 RCSB], [http://www.ebi.ac.uk/pdbsum/6d69 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d69 ProSAT]</span></td></tr>
-	[[Category: Ramyar, K.X]]	+	</table>
-	[[Category: ~~Geisbrecht, B.V~~]]	+	__TOC__
-	[[Category: ~~Mcwhorter, W.J~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Geisbrecht, B V]]
		+	[[Category: McWhorter, W J]]
		+	[[Category: Ramyar, K X]]
		+	[[Category: Beta-propeller]]
		+	[[Category: Limb girdle muscular dystrophy type 2h]]
		+	[[Category: Protein binding]]
		+	[[Category: Protein-protein interaction]]

OCA at 04:01, 16 May 2018

OCA — Wed, 16 May 2018 04:01:13 GMT

←Older revision		Revision as of 04:01, 16 May 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6d69 is ON HOLD	+	The entry 6d69 is ON HOLD until Paper Publication

	Authors: Ramyar, K.X., McWhorter, W.J., Geisbrecht, B.V.		Authors: Ramyar, K.X., McWhorter, W.J., Geisbrecht, B.V.
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	Description: Crystal Structure of the NHL Repeat Region of D. melanogaster Thin		Description: Crystal Structure of the NHL Repeat Region of D. melanogaster Thin
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Mcwhorter, W.J]]
	[[Category: Ramyar, K.X]]		[[Category: Ramyar, K.X]]
	[[Category: Geisbrecht, B.V]]		[[Category: Geisbrecht, B.V]]
		+	[[Category: Mcwhorter, W.J]]

OCA: Protected "6d69" [edit=sysop:move=sysop]

OCA — Wed, 02 May 2018 06:43:56 GMT

Protected "6d69" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:43, 2 May 2018

OCA: New page: '''Unreleased structure''' The entry 6d69 is ON HOLD Authors: Ramyar, K.X., McWhorter, W.J., Geisbrecht, B.V. Description: Crystal Structure of the NHL Repeat Region of D. melanogaster...

OCA — Wed, 02 May 2018 06:43:55 GMT

New page: '''Unreleased structure''' The entry 6d69 is ON HOLD Authors: Ramyar, K.X., McWhorter, W.J., Geisbrecht, B.V. Description: Crystal Structure of the NHL Repeat Region of D. melanogaster...

New page

'''Unreleased structure'''

The entry 6d69 is ON HOLD

Authors: Ramyar, K.X., McWhorter, W.J., Geisbrecht, B.V.

Description: Crystal Structure of the NHL Repeat Region of D. melanogaster Thin
[[Category: Unreleased Structures]]
[[Category: Mcwhorter, W.J]]
[[Category: Ramyar, K.X]]
[[Category: Geisbrecht, B.V]]