6dfj - Revision history

OCA at 09:05, 11 November 2020

OCA — Wed, 11 Nov 2020 09:05:09 GMT

←Older revision		Revision as of 09:05, 11 November 2020
Line 1:		Line 1:

	==Crystal structure of anti-Zika antibody Z021 bound to DENV-1 envelope protein DIII==		==Crystal structure of anti-Zika antibody Z021 bound to DENV-1 envelope protein DIII==
-	<StructureSection load='6dfj' size='340' side='right' caption='[[6dfj]], [[Resolution\|resolution]] 2.07Å' scene=''>	+	<StructureSection load='6dfj' size='340' side='right'caption='[[6dfj]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dfj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DFJ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DFJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dfj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DFJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DFJ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dfj OCA], [http://pdbe.org/6dfj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dfj RCSB], [http://www.ebi.ac.uk/pdbsum/6dfj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dfj ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6dfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dfj OCA], [http://pdbe.org/6dfj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dfj RCSB], [http://www.ebi.ac.uk/pdbsum/6dfj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dfj ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 6dfj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6dfj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 25:
	[[Category: Dengue virus 1]]		[[Category: Dengue virus 1]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bjorkman, P J]]		[[Category: Bjorkman, P J]]
	[[Category: Keeffe, J R]]		[[Category: Keeffe, J R]]

OCA at 08:58, 14 November 2018

OCA — Wed, 14 Nov 2018 08:58:43 GMT

←Older revision		Revision as of 08:58, 14 November 2018
Line 3:		Line 3:
	<StructureSection load='6dfj' size='340' side='right' caption='[[6dfj]], [[Resolution\|resolution]] 2.07Å' scene=''>		<StructureSection load='6dfj' size='340' side='right' caption='[[6dfj]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dfj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DFJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DFJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dfj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DFJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DFJ FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dfj OCA], [http://pdbe.org/6dfj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dfj RCSB], [http://www.ebi.ac.uk/pdbsum/6dfj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dfj ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dfj OCA], [http://pdbe.org/6dfj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dfj RCSB], [http://www.ebi.ac.uk/pdbsum/6dfj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dfj ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Zika virus (ZIKV) causes severe neurologic complications and fetal aberrations. Vaccine development is hindered by potential safety concerns due to antibody cross-reactivity with dengue virus and the possibility of disease enhancement. In contrast, passive administration of anti-ZIKV antibodies engineered to prevent enhancement may be safe and effective. Here, we report on human monoclonal antibody Z021, a potent neutralizer that recognizes an epitope on the lateral ridge of the envelope domain III (EDIII) of ZIKV and is protective against ZIKV in mice. When administered to macaques undergoing a high-dose ZIKV challenge, a single anti-EDIII antibody selected for resistant variants. Co-administration of two antibodies, Z004 and Z021, which target distinct sites on EDIII, was associated with a delay and a 3- to 4-log decrease in peak viremia. Moreover, the combination of these antibodies engineered to avoid enhancement prevented viral escape due to mutation in macaques, a natural host for ZIKV.
		+
		+	A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates.,Keeffe JR, Van Rompay KKA, Olsen PC, Wang Q, Gazumyan A, Azzopardi SA, Schaefer-Babajew D, Lee YE, Stuart JB, Singapuri A, Watanabe J, Usachenko J, Ardeshir A, Saeed M, Agudelo M, Eisenreich T, Bournazos S, Oliveira TY, Rice CM, Coffey LL, MacDonald MR, Bjorkman PJ, Nussenzweig MC, Robbiani DF Cell Rep. 2018 Nov 6;25(6):1385-1394.e7. doi: 10.1016/j.celrep.2018.10.031. PMID:30403995<ref>PMID:30403995</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6dfj" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dengue virus 1]]
		+	[[Category: Human]]
	[[Category: Bjorkman, P J]]		[[Category: Bjorkman, P J]]
	[[Category: Keeffe, J R]]		[[Category: Keeffe, J R]]

OCA at 05:54, 24 October 2018

OCA — Wed, 24 Oct 2018 05:54:01 GMT

←Older revision		Revision as of 05:54, 24 October 2018
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-	'''Unreleased structure'''

-	~~The entry 6dfj is ON HOLD until Paper Publication~~	+	==Crystal structure of anti-Zika antibody Z021 bound to DENV-1 envelope protein DIII==
-		+	<StructureSection load='6dfj' size='340' side='right' caption='[[6dfj]], [[Resolution\|resolution]] 2.07Å' scene=''>
-	~~Authors: Keeffe, J.R., Bjorkman, P.J.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6dfj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DFJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DFJ FirstGlance]. <br>
-	~~Description:~~ Crystal structure of anti-Zika antibody Z021 bound to DENV-1 envelope protein DIII	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dfj OCA], [http://pdbe.org/6dfj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dfj RCSB], [http://www.ebi.ac.uk/pdbsum/6dfj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dfj ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Keeffe~~, J.R]]	+	__TOC__
-	[[Category: Bjorkman, P.J]]	+	</StructureSection>
		+	[[Category: Bjorkman, P J]]
		+	[[Category: Keeffe, J R]]
		+	[[Category: Antibody]]
		+	[[Category: Dengue]]
		+	[[Category: Fab]]
		+	[[Category: Immune system]]
		+	[[Category: Neutralizing]]
		+	[[Category: Recurrent]]
		+	[[Category: Zika]]

OCA at 05:35, 14 June 2018

OCA — Thu, 14 Jun 2018 05:35:36 GMT

←Older revision		Revision as of 05:35, 14 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dfj is ON HOLD	+	The entry 6dfj is ON HOLD until Paper Publication

	Authors: Keeffe, J.R., Bjorkman, P.J.		Authors: Keeffe, J.R., Bjorkman, P.J.

OCA: Protected "6dfj" [edit=sysop:move=sysop]

OCA — Wed, 23 May 2018 06:02:57 GMT

Protected "6dfj" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:02, 23 May 2018

OCA: New page: '''Unreleased structure''' The entry 6dfj is ON HOLD Authors: Keeffe, J.R., Bjorkman, P.J. Description: Crystal structure of anti-Zika antibody Z021 bound to DENV-1 envelope protein DI...

OCA — Wed, 23 May 2018 06:02:55 GMT

New page: '''Unreleased structure''' The entry 6dfj is ON HOLD Authors: Keeffe, J.R., Bjorkman, P.J. Description: Crystal structure of anti-Zika antibody Z021 bound to DENV-1 envelope protein DI...

New page

'''Unreleased structure'''

The entry 6dfj is ON HOLD

Authors: Keeffe, J.R., Bjorkman, P.J.

Description: Crystal structure of anti-Zika antibody Z021 bound to DENV-1 envelope protein DIII
[[Category: Unreleased Structures]]
[[Category: Keeffe, J.R]]
[[Category: Bjorkman, P.J]]