6dg3 - Revision history

OCA at 06:05, 11 October 2023

OCA — Wed, 11 Oct 2023 06:05:34 GMT

←Older revision		Revision as of 06:05, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6dg3' size='340' side='right'caption='[[6dg3]], [[Resolution\|resolution]] 2.94Å' scene=''>		<StructureSection load='6dg3' size='340' side='right'caption='[[6dg3]], [[Resolution\|resolution]] 2.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dg3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lacpl Lacpl~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DG3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dg3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactiplantibacillus_plantarum_WCFS1 Lactiplantibacillus plantarum WCFS1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DG3 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CS:CESIUM+ION'>CS</scene>~~, ~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.944Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~larE, lp_0109 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=220668 LACPL])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dg3 OCA], [https://pdbe.org/6dg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dg3 RCSB], [https://www.ebi.ac.uk/pdbsum/6dg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dg3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dg3 OCA], [https://pdbe.org/6dg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dg3 RCSB], [https://www.ebi.ac.uk/pdbsum/6dg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dg3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LARE_LACPL LARE_LACPL]] Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Catalyzes the ATP-dependent incorporation of two sulfur atoms in pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN) to yield pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN). The source of sulfur is the enzyme itself: Cys-176 of LarE is the sulfur donor, thereby being converted into dehydroalanine, and is not regenerated in vivo. Thus, two molecules of LarE undergo sacrificial sulfur transfer to create one P2TMN (PubMed:27114550). Binds nickel (PubMed:24710389). Is required for the activation of the lactate racemase LarA (PubMed:24710389). May also be involved in the activation of other nickel-pincer cofactor-dependent enzymes (PubMed:27114550).<ref>PMID:24710389</ref> <ref>PMID:27114550</ref>	+	[https://www.uniprot.org/uniprot/LARE_LACPL LARE_LACPL] Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Catalyzes the ATP-dependent incorporation of two sulfur atoms in pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN) to yield pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN). The source of sulfur is the enzyme itself: Cys-176 of LarE is the sulfur donor, thereby being converted into dehydroalanine, and is not regenerated in vivo. Thus, two molecules of LarE undergo sacrificial sulfur transfer to create one P2TMN (PubMed:27114550). Binds nickel (PubMed:24710389). Is required for the activation of the lactate racemase LarA (PubMed:24710389). May also be involved in the activation of other nickel-pincer cofactor-dependent enzymes (PubMed:27114550).<ref>PMID:24710389</ref> <ref>PMID:27114550</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lacpl~~]]	+	[[Category: Lactiplantibacillus plantarum WCFS1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fellner, M]]	+	[[Category: Fellner M]]
-	[[Category: Hausinger~~, R P~~]]	+	[[Category: Hausinger RP]]
-	[[Category: Hu, J]]	+	[[Category: Hu J]]
-	~~[[Category: Ampylation]]~~	+
-	~~[[Category: Atp pyrophophatase domain]]~~	+
-	~~[[Category: Caesium]]~~	+
-	~~[[Category: Hexamer]]~~	+
-	~~[[Category: Lactate]]~~	+
-	~~[[Category: Lactate racemase]]~~	+
-	~~[[Category: Lactate racemization]]~~	+
-	~~[[Category: Lar]]~~	+
-	~~[[Category: Lare]]~~	+
-	~~[[Category: Pp-loop]]~~	+
-	~~[[Category: Sulfur transferase]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Trimer~~]]	+

OCA at 09:32, 12 May 2021

OCA — Wed, 12 May 2021 09:32:46 GMT

←Older revision		Revision as of 09:32, 12 May 2021
Line 3:		Line 3:
	<StructureSection load='6dg3' size='340' side='right'caption='[[6dg3]], [[Resolution\|resolution]] 2.94Å' scene=''>		<StructureSection load='6dg3' size='340' side='right'caption='[[6dg3]], [[Resolution\|resolution]] 2.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dg3]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lacpl Lacpl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DG3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DG3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dg3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacpl Lacpl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DG3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">larE, lp_0109 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=220668 LACPL])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">larE, lp_0109 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=220668 LACPL])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dg3 OCA], [~~http~~://pdbe.org/6dg3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6dg3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6dg3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6dg3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dg3 OCA], [https://pdbe.org/6dg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dg3 RCSB], [https://www.ebi.ac.uk/pdbsum/6dg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dg3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LARE_LACPL LARE_LACPL]] Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Catalyzes the ATP-dependent incorporation of two sulfur atoms in pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN) to yield pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN). The source of sulfur is the enzyme itself: Cys-176 of LarE is the sulfur donor, thereby being converted into dehydroalanine, and is not regenerated in vivo. Thus, two molecules of LarE undergo sacrificial sulfur transfer to create one P2TMN (PubMed:27114550). Binds nickel (PubMed:24710389). Is required for the activation of the lactate racemase LarA (PubMed:24710389). May also be involved in the activation of other nickel-pincer cofactor-dependent enzymes (PubMed:27114550).<ref>PMID:24710389</ref> <ref>PMID:27114550</ref>	+	[[https://www.uniprot.org/uniprot/LARE_LACPL LARE_LACPL]] Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Catalyzes the ATP-dependent incorporation of two sulfur atoms in pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN) to yield pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN). The source of sulfur is the enzyme itself: Cys-176 of LarE is the sulfur donor, thereby being converted into dehydroalanine, and is not regenerated in vivo. Thus, two molecules of LarE undergo sacrificial sulfur transfer to create one P2TMN (PubMed:27114550). Binds nickel (PubMed:24710389). Is required for the activation of the lactate racemase LarA (PubMed:24710389). May also be involved in the activation of other nickel-pincer cofactor-dependent enzymes (PubMed:27114550).<ref>PMID:24710389</ref> <ref>PMID:27114550</ref>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:31, 27 November 2019

OCA — Wed, 27 Nov 2019 08:31:37 GMT

←Older revision		Revision as of 08:31, 27 November 2019
Line 3:		Line 3:
	<StructureSection load='6dg3' size='340' side='right'caption='[[6dg3]], [[Resolution\|resolution]] 2.94Å' scene=''>		<StructureSection load='6dg3' size='340' side='right'caption='[[6dg3]], [[Resolution\|resolution]] 2.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dg3]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DG3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dg3]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Lacpl Lacpl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DG3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">larE, lp_0109 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=220668 LACPL])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dg3 OCA], [http://pdbe.org/6dg3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dg3 RCSB], [http://www.ebi.ac.uk/pdbsum/6dg3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dg3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dg3 OCA], [http://pdbe.org/6dg3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dg3 RCSB], [http://www.ebi.ac.uk/pdbsum/6dg3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dg3 ProSAT]</span></td></tr>
	</table>		</table>
Line 13:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lacpl]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Fellner, M]]		[[Category: Fellner, M]]

OCA at 06:43, 23 May 2019

OCA — Thu, 23 May 2019 06:43:08 GMT

←Older revision		Revision as of 06:43, 23 May 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6dg3 is ~~ON HOLD until Paper Publication~~	+	==LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase, in complex with caesium==
-		+	<StructureSection load='6dg3' size='340' side='right'caption='[[6dg3]], [[Resolution\|resolution]] 2.94Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6dg3]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DG3 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dg3 OCA], [http://pdbe.org/6dg3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dg3 RCSB], [http://www.ebi.ac.uk/pdbsum/6dg3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dg3 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LARE_LACPL LARE_LACPL]] Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Catalyzes the ATP-dependent incorporation of two sulfur atoms in pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN) to yield pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN). The source of sulfur is the enzyme itself: Cys-176 of LarE is the sulfur donor, thereby being converted into dehydroalanine, and is not regenerated in vivo. Thus, two molecules of LarE undergo sacrificial sulfur transfer to create one P2TMN (PubMed:27114550). Binds nickel (PubMed:24710389). Is required for the activation of the lactate racemase LarA (PubMed:24710389). May also be involved in the activation of other nickel-pincer cofactor-dependent enzymes (PubMed:27114550).<ref>PMID:24710389</ref> <ref>PMID:27114550</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Fellner, M]]
		+	[[Category: Hausinger, R P]]
		+	[[Category: Hu, J]]
		+	[[Category: Ampylation]]
		+	[[Category: Atp pyrophophatase domain]]
		+	[[Category: Caesium]]
		+	[[Category: Hexamer]]
		+	[[Category: Lactate]]
		+	[[Category: Lactate racemase]]
		+	[[Category: Lactate racemization]]
		+	[[Category: Lar]]
		+	[[Category: Lare]]
		+	[[Category: Pp-loop]]
		+	[[Category: Sulfur transferase]]
		+	[[Category: Transferase]]
		+	[[Category: Trimer]]

OCA at 04:04, 30 May 2018

OCA — Wed, 30 May 2018 04:04:53 GMT

←Older revision		Revision as of 04:04, 30 May 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dg3 is ON HOLD	+	The entry 6dg3 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6dg3" [edit=sysop:move=sysop]

OCA — Wed, 23 May 2018 06:04:27 GMT

Protected "6dg3" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:04, 23 May 2018

OCA: New page: '''Unreleased structure''' The entry 6dg3 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 23 May 2018 06:04:26 GMT

New page: '''Unreleased structure''' The entry 6dg3 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6dg3 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]