6dg7 - Revision history

OCA at 00:03, 11 April 2020

OCA — Sat, 11 Apr 2020 00:03:20 GMT

←Older revision		Revision as of 00:03, 11 April 2020
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	<SX load='6dg7' size='340' side='right' viewer='molstar' caption='[[6dg7]], [[Resolution\|resolution]] 3.32Å' scene=''>		<SX load='6dg7' size='340' side='right' viewer='molstar' caption='[[6dg7]], [[Resolution\|resolution]] 3.32Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dg7]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DG7 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DG7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dg7]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DG7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DG7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SRO:SEROTONIN'>SRO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SRO:SEROTONIN'>SRO</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Htr3a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Htr3a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dg7 OCA], [http://pdbe.org/6dg7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dg7 RCSB], [http://www.ebi.ac.uk/pdbsum/6dg7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dg7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6dg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dg7 OCA], [http://pdbe.org/6dg7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dg7 RCSB], [http://www.ebi.ac.uk/pdbsum/6dg7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dg7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:53, 6 March 2020

OCA — Fri, 06 Mar 2020 20:53:47 GMT

←Older revision		Revision as of 20:53, 6 March 2020
Line 1:		Line 1:

	==Full-length 5-HT3A receptor in a serotonin-bound conformation- State 1==		==Full-length 5-HT3A receptor in a serotonin-bound conformation- State 1==
-	<~~StructureSection~~ load='6dg7' size='340' side='right'caption='[[6dg7]], [[Resolution\|resolution]] 3.32Å' scene=''>	+	<SX load='6dg7' size='340' side='right' viewer='molstar' caption='[[6dg7]], [[Resolution\|resolution]] 3.32Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6dg7]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DG7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6dg7]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DG7 FirstGlance]. <br>
Line 23:		Line 23:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]

OCA at 08:51, 8 January 2020

OCA — Wed, 08 Jan 2020 08:51:46 GMT

←Older revision		Revision as of 08:51, 8 January 2020
Line 1:		Line 1:

	==Full-length 5-HT3A receptor in a serotonin-bound conformation- State 1==		==Full-length 5-HT3A receptor in a serotonin-bound conformation- State 1==
-	<StructureSection load='6dg7' size='340' side='right' caption='[[6dg7]], [[Resolution\|resolution]] 3.32Å' scene=''>	+	<StructureSection load='6dg7' size='340' side='right'caption='[[6dg7]], [[Resolution\|resolution]] 3.32Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dg7]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DG7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dg7]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DG7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SRO:SEROTONIN'>SRO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SRO:SEROTONIN'>SRO</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Htr3a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dg7 OCA], [http://pdbe.org/6dg7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dg7 RCSB], [http://www.ebi.ac.uk/pdbsum/6dg7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dg7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dg7 OCA], [http://pdbe.org/6dg7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dg7 RCSB], [http://www.ebi.ac.uk/pdbsum/6dg7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dg7 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The 5-HT3A serotonin receptor(1), a cationic pentameric ligand-gated ion channel (pLGIC), is the clinical target for management of nausea and vomiting associated with radiation and chemotherapies(2). Upon binding, serotonin induces a global conformational change that encompasses the ligand-binding extracellular domain (ECD), the transmembrane domain (TMD) and the intracellular domain (ICD), the molecular details of which are unclear. Here we present two serotonin-bound structures of the full-length 5-HT3A receptor in distinct conformations at 3.32 A and 3.89 A resolution that reveal the mechanism underlying channel activation. In comparison to the apo 5-HT3A receptor, serotonin-bound states underwent a large twisting motion in the ECD and TMD, leading to the opening of a 165 A permeation pathway. Notably, this motion results in the creation of lateral portals for ion permeation at the interface of the TMD and ICD. Combined with molecular dynamics simulations, these structures provide novel insights into conformational coupling across domains and functional modulation.
		+
		+	Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3A receptor.,Basak S, Gicheru Y, Rao S, Sansom MSP, Chakrapani S Nature. 2018 Nov;563(7730):270-274. doi: 10.1038/s41586-018-0660-7. Epub 2018 Oct, 31. PMID:30401837<ref>PMID:30401837</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6dg7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[5-hydroxytryptamine receptor 3D structures\|5-hydroxytryptamine receptor 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Basak, S]]		[[Category: Basak, S]]
	[[Category: Chakrapani, S]]		[[Category: Chakrapani, S]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]

OCA at 12:13, 7 November 2018

OCA — Wed, 07 Nov 2018 12:13:55 GMT

←Older revision		Revision as of 12:13, 7 November 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6dg7 is ~~ON HOLD until Paper Publication~~	+	==Full-length 5-HT3A receptor in a serotonin-bound conformation- State 1==
-		+	<StructureSection load='6dg7' size='340' side='right' caption='[[6dg7]], [[Resolution\|resolution]] 3.32Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6dg7]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DG7 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SRO:SEROTONIN'>SRO</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dg7 OCA], [http://pdbe.org/6dg7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dg7 RCSB], [http://www.ebi.ac.uk/pdbsum/6dg7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dg7 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Basak, S]]
		+	[[Category: Chakrapani, S]]
		+	[[Category: Membrane protein]]

OCA at 04:04, 30 May 2018

OCA — Wed, 30 May 2018 04:04:56 GMT

←Older revision		Revision as of 04:04, 30 May 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dg7 is ON HOLD	+	The entry 6dg7 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6dg7" [edit=sysop:move=sysop]

OCA — Wed, 23 May 2018 06:04:47 GMT

Protected "6dg7" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:04, 23 May 2018

OCA: New page: '''Unreleased structure''' The entry 6dg7 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 23 May 2018 06:04:46 GMT

New page: '''Unreleased structure''' The entry 6dg7 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6dg7 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]