6dgc - Revision history

OCA at 06:05, 11 October 2023

OCA — Wed, 11 Oct 2023 06:05:38 GMT

←Older revision		Revision as of 06:05, 11 October 2023
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	<StructureSection load='6dgc' size='340' side='right'caption='[[6dgc]], [[Resolution\|resolution]] 2.92Å' scene=''>		<StructureSection load='6dgc' size='340' side='right'caption='[[6dgc]], [[Resolution\|resolution]] 2.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dgc]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Sulfolobus_sp.~~_l00_11~~ Sulfolobus sp. ~~l00~~ 11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DGC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DGC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dgc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_sp._L00_11 Sulfolobus sp. L00 11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DGC FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dgc OCA], [~~http~~://pdbe.org/6dgc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6dgc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6dgc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6dgc ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.92Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dgc OCA], [https://pdbe.org/6dgc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dgc RCSB], [https://www.ebi.ac.uk/pdbsum/6dgc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dgc ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5MPE7_9CREN Q5MPE7_9CREN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6dgc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6dgc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transposase 3D structures\|Transposase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Sulfolobus sp. ~~l00~~ 11]]	+	[[Category: Sulfolobus sp. L00 11]]
-	[[Category: Cascio, D]]	+	[[Category: Cascio D]]
-	[[Category: Hancock~~, S P~~]]	+	[[Category: Hancock SP]]
-	[[Category: Johnson~~, R C~~]]	+	[[Category: Johnson RC]]
-	[[Category: Kumar, P]]	+	[[Category: Kumar P]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Is607-like serine recombinase~~]]	+

OCA at 08:10, 3 April 2019

OCA — Wed, 03 Apr 2019 08:10:54 GMT

←Older revision		Revision as of 08:10, 3 April 2019
Line 1:		Line 1:

	==Crystal structure of the C-terminal catalytic domain of ISC1926 TnpA, an IS607-like serine recombinase==		==Crystal structure of the C-terminal catalytic domain of ISC1926 TnpA, an IS607-like serine recombinase==
-	<StructureSection load='6dgc' size='340' side='right' caption='[[6dgc]], [[Resolution\|resolution]] 2.92Å' scene=''>	+	<StructureSection load='6dgc' size='340' side='right'caption='[[6dgc]], [[Resolution\|resolution]] 2.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dgc]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DGC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DGC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dgc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_sp._l00_11 Sulfolobus sp. l00 11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DGC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DGC FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dgc OCA], [http://pdbe.org/6dgc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dgc RCSB], [http://www.ebi.ac.uk/pdbsum/6dgc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dgc ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dgc OCA], [http://pdbe.org/6dgc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dgc RCSB], [http://www.ebi.ac.uk/pdbsum/6dgc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dgc ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	IS607-family transposons are unusual because they do not have terminal inverted repeats or generate target site duplications. They encode two protein-coding genes, but only tnpA is required for transposition. Our X-ray structures confirm that TnpA is a member of the serine recombinase (SR) family, but the chemically-inactive quaternary structure of the dimer, along with the N-terminal location of the DNA binding domain, are different from other SRs. TnpA dimers from IS1535 cooperatively associate with multiple subterminal repeats, which together with additional nonspecific binding, form a nucleoprotein filament on one transposon end that efficiently captures a second unbound end to generate the paired-end complex (PEC). Formation of the PEC does not require a change in the dimeric structure of the catalytic domain, but remodeling of the C-terminal alpha-helical region is involved. We posit that the PEC recruits a chemically-active conformer of TnpA to the transposon end to initiate DNA chemistry.
		+
		+	Multiple serine transposase dimers assemble the transposon-end synaptic complex during IS607-family transposition.,Chen W, Mandali S, Hancock SP, Kumar P, Collazo M, Cascio D, Johnson RC Elife. 2018 Oct 5;7. pii: 39611. doi: 10.7554/eLife.39611. PMID:30289389<ref>PMID:30289389</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6dgc" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Sulfolobus sp. l00 11]]
	[[Category: Cascio, D]]		[[Category: Cascio, D]]
	[[Category: Hancock, S P]]		[[Category: Hancock, S P]]

OCA at 07:38, 18 July 2018

OCA — Wed, 18 Jul 2018 07:38:58 GMT

←Older revision		Revision as of 07:38, 18 July 2018
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-	'''Unreleased structure'''

-	~~The entry 6dgc is ON HOLD until Paper Publication~~	+	==Crystal structure of the C-terminal catalytic domain of ISC1926 TnpA, an IS607-like serine recombinase==
-		+	<StructureSection load='6dgc' size='340' side='right' caption='[[6dgc]], [[Resolution\|resolution]] 2.92Å' scene=''>
-	~~Authors: Hancock, S.P., Kumar, P., Cascio, D., Johnson, R.C.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6dgc]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DGC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DGC FirstGlance]. <br>
-	~~Description:~~ Crystal structure of the C-terminal catalytic domain of ISC1926 TnpA, an IS607-like serine recombinase	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dgc OCA], [http://pdbe.org/6dgc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dgc RCSB], [http://www.ebi.ac.uk/pdbsum/6dgc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dgc ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Hancock~~, S.P]]	+	__TOC__
		+	</StructureSection>
	[[Category: Cascio, D]]		[[Category: Cascio, D]]
		+	[[Category: Hancock, S P]]
		+	[[Category: Johnson, R C]]
	[[Category: Kumar, P]]		[[Category: Kumar, P]]
-	[[Category: ~~Johnson, R.C~~]]	+	[[Category: Hydrolase]]
		+	[[Category: Is607-like serine recombinase]]

OCA at 05:35, 14 June 2018

OCA — Thu, 14 Jun 2018 05:35:52 GMT

←Older revision		Revision as of 05:35, 14 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dgc is ON HOLD	+	The entry 6dgc is ON HOLD until Paper Publication

	Authors: Hancock, S.P., Kumar, P., Cascio, D., Johnson, R.C.		Authors: Hancock, S.P., Kumar, P., Cascio, D., Johnson, R.C.
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Hancock, S.P]]		[[Category: Hancock, S.P]]
		+	[[Category: Cascio, D]]
	[[Category: Kumar, P]]		[[Category: Kumar, P]]
	[[Category: Johnson, R.C]]		[[Category: Johnson, R.C]]
-	[[Category: Cascio, D]]

OCA: Protected "6dgc" [edit=sysop:move=sysop]

OCA — Wed, 23 May 2018 06:05:21 GMT

Protected "6dgc" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:05, 23 May 2018

OCA: New page: '''Unreleased structure''' The entry 6dgc is ON HOLD Authors: Hancock, S.P., Kumar, P., Cascio, D., Johnson, R.C. Description: Crystal structure of the C-terminal catalytic domain of I...

OCA — Wed, 23 May 2018 06:05:19 GMT

New page: '''Unreleased structure''' The entry 6dgc is ON HOLD Authors: Hancock, S.P., Kumar, P., Cascio, D., Johnson, R.C. Description: Crystal structure of the C-terminal catalytic domain of I...

New page

'''Unreleased structure'''

The entry 6dgc is ON HOLD

Authors: Hancock, S.P., Kumar, P., Cascio, D., Johnson, R.C.

Description: Crystal structure of the C-terminal catalytic domain of ISC1926 TnpA, an IS607-like serine recombinase
[[Category: Unreleased Structures]]
[[Category: Hancock, S.P]]
[[Category: Kumar, P]]
[[Category: Johnson, R.C]]
[[Category: Cascio, D]]