6di7 - Revision history

OCA at 06:06, 11 October 2023

OCA — Wed, 11 Oct 2023 06:06:58 GMT

←Older revision		Revision as of 06:06, 11 October 2023
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	<StructureSection load='6di7' size='340' side='right'caption='[[6di7]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='6di7' size='340' side='right'caption='[[6di7]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6di7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Chatd Chatd~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DI7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DI7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6di7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DI7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=GDP:GUANOSINE~~-~~5-DIPHOSPHATE'>GDP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~CTHT_0061810 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=5~~&id~~=~~759272 CHATD])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6di7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6di7 OCA], [~~http~~://pdbe.org/6di7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6di7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6di7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6di7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6di7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6di7 OCA], [https://pdbe.org/6di7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6di7 RCSB], [https://www.ebi.ac.uk/pdbsum/6di7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6di7 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G0SFF0_CHATD G0SFF0_CHATD]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chatd~~]]	+	[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brady~~, T M~~]]	+	[[Category: Brady TM]]
-	[[Category: Ford~~, M G.J~~]]	+	[[Category: Ford MGJ]]
-	[[Category: Varlakhanova~~, N V]]~~	+	[[Category: Varlakhanova NV]]
-	~~[[Category: Drp]]~~	+
-	~~[[Category: Dynamin]]~~	+
-	~~[[Category: Dynamin-related protein]]~~	+
-	~~[[Category: Endosome]]~~	+
-	~~[[Category: Gdp]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Vacuolar protein sorting 1]]~~	+
-	~~[[Category: Vacuole]]~~	+
-	~~[[Category: Vps1~~]]	+

OCA at 11:03, 1 January 2020

OCA — Wed, 01 Jan 2020 11:03:48 GMT

←Older revision		Revision as of 11:03, 1 January 2020
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	==Vps1 GTPase-BSE fusion complexed with GDP==		==Vps1 GTPase-BSE fusion complexed with GDP==
-	<StructureSection load='6di7' size='340' side='right' caption='[[6di7]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='6di7' size='340' side='right'caption='[[6di7]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6di7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DI7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DI7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6di7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DI7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DI7 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Chatd]]		[[Category: Chatd]]
		+	[[Category: Large Structures]]
	[[Category: Brady, T M]]		[[Category: Brady, T M]]
	[[Category: Ford, M G.J]]		[[Category: Ford, M G.J]]

OCA at 08:36, 17 October 2018

OCA — Wed, 17 Oct 2018 08:36:29 GMT

←Older revision		Revision as of 08:36, 17 October 2018
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	<StructureSection load='6di7' size='340' side='right' caption='[[6di7]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='6di7' size='340' side='right' caption='[[6di7]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6di7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DI7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DI7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6di7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DI7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DI7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0061810 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6di7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6di7 OCA], [http://pdbe.org/6di7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6di7 RCSB], [http://www.ebi.ac.uk/pdbsum/6di7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6di7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6di7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6di7 OCA], [http://pdbe.org/6di7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6di7 RCSB], [http://www.ebi.ac.uk/pdbsum/6di7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6di7 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Chatd]]
	[[Category: Brady, T M]]		[[Category: Brady, T M]]
	[[Category: Ford, M G.J]]		[[Category: Ford, M G.J]]

OCA at 06:08, 22 August 2018

OCA — Wed, 22 Aug 2018 06:08:01 GMT

←Older revision		Revision as of 06:08, 22 August 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6di7 is ~~ON HOLD until Paper~~ Publication	+	==Vps1 GTPase-BSE fusion complexed with GDP==
		+	<StructureSection load='6di7' size='340' side='right' caption='[[6di7]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6di7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DI7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DI7 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6di7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6di7 OCA], [http://pdbe.org/6di7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6di7 RCSB], [http://www.ebi.ac.uk/pdbsum/6di7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6di7 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dynamin-related proteins (DRPs) are large multidomain GTPases required for diverse membrane-remodeling events. DRPs self-assemble into helical structures, but how these structures are tailored to their cellular targets remains unclear. We demonstrate that the fungal DRP Vps1 primarily localizes to and functions at the endosomal compartment. We present crystal structures of a Vps1 GTPase-bundle signaling element (BSE) fusion in different nucleotide states to capture GTP hydrolysis intermediates and concomitant conformational changes. Using cryoEM, we determined the structure of full-length GMPPCP-bound Vps1. The Vps1 helix is more open and flexible than that of dynamin. This is due to further opening of the BSEs away from the GTPase domains. A novel interface between adjacent GTPase domains forms in Vps1 instead of the contacts between the BSE and adjacent stalks and GTPase domains as seen in dynamin. Disruption of this interface abolishes Vps1 function in vivo. Hence, Vps1 exhibits a unique helical architecture, highlighting structural flexibilities of DRP self-assembly.

-	~~Authors: Varlakhanova~~, ~~N.V~~., Brady, ~~T.M.~~, ~~Ford~~, M.G.J.	+	Structures of the fungal dynamin-related protein Vps1 reveal a unique, open helical architecture.,Varlakhanova NV, Alvarez FJD, Brady TM, Tornabene BA, Hosford CJ, Chappie JS, Zhang P, Ford MGJ J Cell Biol. 2018 Aug 7. pii: jcb.201712021. doi: 10.1083/jcb.201712021. PMID:30087125<ref>PMID:30087125</ref>

-	~~Description: Vps1 GTPase~~-~~BSE fusion complexed with GDP~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: Ford, M.G.J]]	+	<div class="pdbe-citations 6di7" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Brady~~, ~~T.M~~]]	+	== References ==
-	[[Category: ~~Varlakhanova, N.V~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Brady, T M]]
		+	[[Category: Ford, M G.J]]
		+	[[Category: Varlakhanova, N V]]
		+	[[Category: Drp]]
		+	[[Category: Dynamin]]
		+	[[Category: Dynamin-related protein]]
		+	[[Category: Endosome]]
		+	[[Category: Gdp]]
		+	[[Category: Hydrolase]]
		+	[[Category: Vacuolar protein sorting 1]]
		+	[[Category: Vacuole]]
		+	[[Category: Vps1]]

OCA at 19:45, 9 August 2018

OCA — Thu, 09 Aug 2018 19:45:47 GMT

←Older revision		Revision as of 19:45, 9 August 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6di7 is ON HOLD	+	The entry 6di7 is ON HOLD until Paper Publication

	Authors: Varlakhanova, N.V., Brady, T.M., Ford, M.G.J.		Authors: Varlakhanova, N.V., Brady, T.M., Ford, M.G.J.

OCA: Protected "6di7" [edit=sysop:move=sysop]

OCA — Wed, 30 May 2018 04:09:39 GMT

Protected "6di7" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:09, 30 May 2018

OCA: New page: '''Unreleased structure''' The entry 6di7 is ON HOLD Authors: Varlakhanova, N.V., Brady, T.M., Ford, M.G.J. Description: Vps1 GTPase-BSE fusion complexed with GDP [[Category: Unrelease...

OCA — Wed, 30 May 2018 04:09:38 GMT

New page: '''Unreleased structure''' The entry 6di7 is ON HOLD Authors: Varlakhanova, N.V., Brady, T.M., Ford, M.G.J. Description: Vps1 GTPase-BSE fusion complexed with GDP [[Category: Unrelease...

New page

'''Unreleased structure'''

The entry 6di7 is ON HOLD

Authors: Varlakhanova, N.V., Brady, T.M., Ford, M.G.J.

Description: Vps1 GTPase-BSE fusion complexed with GDP
[[Category: Unreleased Structures]]
[[Category: Ford, M.G.J]]
[[Category: Brady, T.M]]
[[Category: Varlakhanova, N.V]]