6dir - Revision history

OCA at 06:07, 11 October 2023

OCA — Wed, 11 Oct 2023 06:07:25 GMT

←Older revision		Revision as of 06:07, 11 October 2023
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	<StructureSection load='6dir' size='340' side='right'caption='[[6dir]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='6dir' size='340' side='right'caption='[[6dir]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dir]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~9hepc 9hepc~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DIR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DIR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dir]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DIR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GKA:(2R,6S,12Z,13aS,14aR,16aS)-6-[(N-acetyl-3-methyl-L-valyl)amino]-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-N-[(1-~~methylcyclopropyl~~)sulfonyl]-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]~~diazacyclopentadecine~~-14a(5H)-carboxamide'>GKA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.751Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dir OCA], [~~http~~://pdbe.org/6dir PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6dir RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6dir PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6dir ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GKA:(2R,6S,12Z,13aS,14aR,16aS)-6-[(N-acetyl-3-methyl-L-valyl)amino]-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-N-[(1-methyl+cyclopropyl)sulfonyl]-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diaz+acyclopentadecine-14a(5H)-carboxamide'>GKA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dir OCA], [https://pdbe.org/6dir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dir RCSB], [https://www.ebi.ac.uk/pdbsum/6dir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dir ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0B4WYC6_9HEPC A0A0B4WYC6_9HEPC]
		+
		+	==See Also==
		+	*[[Virus protease 3D structures\|Virus protease 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hepacivirus C]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Matthew~~, A N~~]]	+	[[Category: Matthew AN]]
-	[[Category: Schiffer~~, C A]]~~	+	[[Category: Schiffer CA]]
-	~~[[Category: Drug resistance]]~~	+
-	~~[[Category: Hepatitis c virus]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Ns3/4a protease]]~~	+
-	~~[[Category: Protease inhibitor~~]]	+

OCA at 10:10, 18 December 2019

OCA — Wed, 18 Dec 2019 10:10:20 GMT

←Older revision		Revision as of 10:10, 18 December 2019
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	<StructureSection load='6dir' size='340' side='right'caption='[[6dir]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='6dir' size='340' side='right'caption='[[6dir]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dir]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DIR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dir]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9hepc 9hepc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DIR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GKA:(2R,6S,12Z,13aS,14aR,16aS)-6-[(N-acetyl-3-methyl-L-valyl)amino]-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-N-[(1-methylcyclopropyl)sulfonyl]-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxamide'>GKA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GKA:(2R,6S,12Z,13aS,14aR,16aS)-6-[(N-acetyl-3-methyl-L-valyl)amino]-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-N-[(1-methylcyclopropyl)sulfonyl]-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxamide'>GKA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dir OCA], [http://pdbe.org/6dir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dir RCSB], [http://www.ebi.ac.uk/pdbsum/6dir PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dir ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dir OCA], [http://pdbe.org/6dir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dir RCSB], [http://www.ebi.ac.uk/pdbsum/6dir PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dir ProSAT]</span></td></tr>

OCA at 06:09, 31 July 2019

OCA — Wed, 31 Jul 2019 06:09:29 GMT

←Older revision		Revision as of 06:09, 31 July 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6dir is ON HOLD until Jul 23 2020~~	+	==Crystal structure of HCV NS3/4A protease in complex with P4-P5-2 (AJ-67)==
-		+	<StructureSection load='6dir' size='340' side='right'caption='[[6dir]], [[Resolution\|resolution]] 1.75Å' scene=''>
-	~~Authors: Matthew, A.N., Schiffer, C.A.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6dir]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DIR FirstGlance]. <br>
-	~~Description:~~ Crystal structure of HCV NS3/4A protease in complex with P4-P5-2 (AJ-67)	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GKA:(2R,6S,12Z,13aS,14aR,16aS)-6-[(N-acetyl-3-methyl-L-valyl)amino]-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-N-[(1-methylcyclopropyl)sulfonyl]-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxamide'>GKA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dir OCA], [http://pdbe.org/6dir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dir RCSB], [http://www.ebi.ac.uk/pdbsum/6dir PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dir ProSAT]</span></td></tr>
-	[[Category: Matthew, A.N]]	+	</table>
-	[[Category: Schiffer, C.A]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Matthew, A N]]
		+	[[Category: Schiffer, C A]]
		+	[[Category: Drug resistance]]
		+	[[Category: Hepatitis c virus]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Ns3/4a protease]]
		+	[[Category: Protease inhibitor]]

OCA at 06:50, 1 May 2019

OCA — Wed, 01 May 2019 06:50:23 GMT

←Older revision		Revision as of 06:50, 1 May 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dir is ON HOLD until ~~Paper Publication~~	+	The entry 6dir is ON HOLD until Jul 23 2020

	Authors: Matthew, A.N., Schiffer, C.A.		Authors: Matthew, A.N., Schiffer, C.A.
Line 7:		Line 7:
	Description: Crystal structure of HCV NS3/4A protease in complex with P4-P5-2 (AJ-67)		Description: Crystal structure of HCV NS3/4A protease in complex with P4-P5-2 (AJ-67)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Schiffer, C.A]]
	[[Category: Matthew, A.N]]		[[Category: Matthew, A.N]]
		+	[[Category: Schiffer, C.A]]

OCA at 05:37, 14 June 2018

OCA — Thu, 14 Jun 2018 05:37:59 GMT

←Older revision		Revision as of 05:37, 14 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dir is ON HOLD	+	The entry 6dir is ON HOLD until Paper Publication

	Authors: Matthew, A.N., Schiffer, C.A.		Authors: Matthew, A.N., Schiffer, C.A.

OCA: Protected "6dir" [edit=sysop:move=sysop]

OCA — Wed, 30 May 2018 04:11:39 GMT

Protected "6dir" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:11, 30 May 2018

OCA: New page: '''Unreleased structure''' The entry 6dir is ON HOLD Authors: Matthew, A.N., Schiffer, C.A. Description: Crystal structure of HCV NS3/4A protease in complex with P4-P5-2 (AJ-67) [[Cate...

OCA — Wed, 30 May 2018 04:11:38 GMT

New page: '''Unreleased structure''' The entry 6dir is ON HOLD Authors: Matthew, A.N., Schiffer, C.A. Description: Crystal structure of HCV NS3/4A protease in complex with P4-P5-2 (AJ-67) [[Cate...

New page

'''Unreleased structure'''

The entry 6dir is ON HOLD

Authors: Matthew, A.N., Schiffer, C.A.

Description: Crystal structure of HCV NS3/4A protease in complex with P4-P5-2 (AJ-67)
[[Category: Unreleased Structures]]
[[Category: Schiffer, C.A]]
[[Category: Matthew, A.N]]