6djd - Revision history

OCA at 06:07, 11 October 2023

OCA — Wed, 11 Oct 2023 06:07:53 GMT

←Older revision		Revision as of 06:07, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6djd' size='340' side='right'caption='[[6djd]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='6djd' size='340' side='right'caption='[[6djd]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6djd]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DJD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DJD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6djd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DJD FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=EDO:1,2~~-~~ETHANEDIOL'>EDO</scene>~~, ~~<scene name='pdbligand=GJP:4-hydroxyquinoline-3-carboxylic+acid'>GJP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.777Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~TDP1 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GJP:4-hydroxyquinoline-3-carboxylic+acid'>GJP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6djd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6djd OCA], [~~http~~://pdbe.org/6djd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6djd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6djd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6djd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6djd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6djd OCA], [https://pdbe.org/6djd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6djd RCSB], [https://www.ebi.ac.uk/pdbsum/6djd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6djd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/TYDP1_HUMAN TYDP1_HUMAN]] Defects in TDP1 are the cause of spinocerebellar ataxia autosomal recessive with axonal neuropathy (SCAN1) [MIM:[~~http~~://omim.org/entry/607250 607250]]. SCAN1 is an autosomal recessive cerebellar ataxia (ARCA) associated with peripheral axonal motor and sensory neuropathy, distal muscular atrophy, pes cavus and steppage gait as seen in Charcot-Marie-Tooth neuropathy. All affected individuals have normal intelligence.<ref>PMID:16141202</ref> <ref>PMID:15647511</ref> <ref>PMID:12244316</ref> <ref>PMID:17948061</ref> <ref>PMID:15920477</ref>	+	[https://www.uniprot.org/uniprot/TYDP1_HUMAN TYDP1_HUMAN] Defects in TDP1 are the cause of spinocerebellar ataxia autosomal recessive with axonal neuropathy (SCAN1) [MIM:[https://omim.org/entry/607250 607250]. SCAN1 is an autosomal recessive cerebellar ataxia (ARCA) associated with peripheral axonal motor and sensory neuropathy, distal muscular atrophy, pes cavus and steppage gait as seen in Charcot-Marie-Tooth neuropathy. All affected individuals have normal intelligence.<ref>PMID:16141202</ref> <ref>PMID:15647511</ref> <ref>PMID:12244316</ref> <ref>PMID:17948061</ref> <ref>PMID:15920477</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TYDP1_HUMAN TYDP1_HUMAN]] DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.<ref>PMID:12023295</ref> <ref>PMID:15111055</ref> <ref>PMID:15811850</ref> <ref>PMID:16141202</ref> <ref>PMID:22822062</ref>	+	[https://www.uniprot.org/uniprot/TYDP1_HUMAN TYDP1_HUMAN] DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.<ref>PMID:12023295</ref> <ref>PMID:15111055</ref> <ref>PMID:15811850</ref> <ref>PMID:16141202</ref> <ref>PMID:22822062</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 6djd" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6djd" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Burke~~, T R~~]]	+	[[Category: Burke Jr TR]]
-	[[Category: Kiselev, E]]	+	[[Category: Kiselev E]]
-	[[Category: Lountos~~, G T~~]]	+	[[Category: Lountos GT]]
-	[[Category: Needle, D]]	+	[[Category: Needle D]]
-	[[Category: Pommier, Y]]	+	[[Category: Pommier Y]]
-	[[Category: Tropea~~, J E~~]]	+	[[Category: Tropea JE]]
-	[[Category: Waugh~~, D S~~]]	+	[[Category: Waugh DS]]
-	[[Category: Zhao~~, X Z]]~~	+	[[Category: Zhao XZ]]
-	~~[[Category: Fragment-based drug design]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]	+

OCA at 06:44, 3 July 2019

OCA — Wed, 03 Jul 2019 06:44:32 GMT

←Older revision		Revision as of 06:44, 3 July 2019
Line 3:		Line 3:
	<StructureSection load='6djd' size='340' side='right'caption='[[6djd]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='6djd' size='340' side='right'caption='[[6djd]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6djd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DJD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6djd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DJD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GJP:4-hydroxyquinoline-3-carboxylic+acid'>GJP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GJP:4-hydroxyquinoline-3-carboxylic+acid'>GJP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TDP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6djd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6djd OCA], [http://pdbe.org/6djd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6djd RCSB], [http://www.ebi.ac.uk/pdbsum/6djd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6djd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6djd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6djd OCA], [http://pdbe.org/6djd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6djd RCSB], [http://www.ebi.ac.uk/pdbsum/6djd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6djd ProSAT]</span></td></tr>
	</table>		</table>
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TYDP1_HUMAN TYDP1_HUMAN]] DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.<ref>PMID:12023295</ref> <ref>PMID:15111055</ref> <ref>PMID:15811850</ref> <ref>PMID:16141202</ref> <ref>PMID:22822062</ref>		[[http://www.uniprot.org/uniprot/TYDP1_HUMAN TYDP1_HUMAN]] DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.<ref>PMID:12023295</ref> <ref>PMID:15111055</ref> <ref>PMID:15811850</ref> <ref>PMID:16141202</ref> <ref>PMID:22822062</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tyrosyl DNA-phosphodiesterase I (TDP1) repairs type IB topoisomerase (TOP1) cleavage complexes generated by TOP1 inhibitors commonly used as anticancer agents. TDP1 also removes DNA 3' end blocking lesions generated by chain-terminating nucleosides and alkylating agents, and base oxidation both in the nuclear and mitochondrial genomes. Combination therapy with TDP1 inhibitors is proposed to synergize with topoisomerase targeting drugs to enhance selectivity against cancer cells exhibiting deficiencies in parallel DNA repair pathways. A crystallographic fragment screening campaign against the catalytic domain of TDP1 was conducted to identify new lead compounds. Crystal structures revealed two fragments that bind to the TDP1 active site and exhibit inhibitory activity against TDP1. These fragments occupy a similar position in the TDP1 active site as seen in prior crystal structures of TDP1 with bound vanadate, a transition state mimic. Using structural insights into fragment binding, several fragment derivatives have been prepared and evaluated in biochemical assays. These results demonstrate that fragment-based methods can be a highly feasible approach toward the discovery of small-molecule chemical scaffolds to target TDP1, and for the first time, we provide co-crystal structures of small molecule inhibitors bound to TDP1, which could serve for the rational development of medicinal TDP1 inhibitors.
		+
		+	Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening.,Lountos GT, Zhao XZ, Kiselev E, Tropea JE, Needle D, Pommier Y, Burke TR, Waugh DS Nucleic Acids Res. 2019 Jun 14. pii: 5519170. doi: 10.1093/nar/gkz515. PMID:31199869<ref>PMID:31199869</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6djd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Burke, T R]]		[[Category: Burke, T R]]

OCA at 06:04, 29 May 2019

OCA — Wed, 29 May 2019 06:04:56 GMT

←Older revision		Revision as of 06:04, 29 May 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6djd ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of Tdp1 catalytic domain in complex with Zenobia fragment ZT1982 (single soak)==
-		+	<StructureSection load='6djd' size='340' side='right'caption='[[6djd]], [[Resolution\|resolution]] 1.78Å' scene=''>
-	~~Authors~~: ~~Lountos, G~~.T.~~, Zhao, X~~.Z.~~, Kiselev, E~~., ~~Tropea~~, J.E., ~~Needle, D~~., ~~Burke Jr~~., T.R., ~~Pommier, Y~~., ~~Waugh, D~~.S.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6djd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DJD FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of Tdp1 catalytic domain~~ in ~~complex~~ with ~~Zenobia fragment ZT1982~~ (~~single soak~~)	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GJP:4-hydroxyquinoline-3-carboxylic+acid'>GJP</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6djd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6djd OCA], [http://pdbe.org/6djd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6djd RCSB], [http://www.ebi.ac.uk/pdbsum/6djd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6djd ProSAT]</span></td></tr>
-	[[~~Category~~: T.R]]	+	</table>
-	[[Category: ~~Pommier, Y~~]]	+	== Disease ==
-	[[Category: ~~Waugh~~, ~~D.S~~]]	+	[[http://www.uniprot.org/uniprot/TYDP1_HUMAN TYDP1_HUMAN]] Defects in TDP1 are the cause of spinocerebellar ataxia autosomal recessive with axonal neuropathy (SCAN1) [MIM:[http://omim.org/entry/607250 607250]]. SCAN1 is an autosomal recessive cerebellar ataxia (ARCA) associated with peripheral axonal motor and sensory neuropathy, distal muscular atrophy, pes cavus and steppage gait as seen in Charcot-Marie-Tooth neuropathy. All affected individuals have normal intelligence.<ref>PMID:16141202</ref> <ref>PMID:15647511</ref> <ref>PMID:12244316</ref> <ref>PMID:17948061</ref> <ref>PMID:15920477</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TYDP1_HUMAN TYDP1_HUMAN]] DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.<ref>PMID:12023295</ref> <ref>PMID:15111055</ref> <ref>PMID:15811850</ref> <ref>PMID:16141202</ref> <ref>PMID:22822062</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Burke, T R]]
	[[Category: Kiselev, E]]		[[Category: Kiselev, E]]
-	[[Category: ~~Zhao~~, ~~X.Z]]~~	+	[[Category: Lountos, G T]]
-	~~[[Category: Tropea, J.E]]~~	+
-	~~[[Category: Burke Jr~~]]	+
	[[Category: Needle, D]]		[[Category: Needle, D]]
-	[[Category: ~~Lountos~~, ~~G.T~~]]	+	[[Category: Pommier, Y]]
		+	[[Category: Tropea, J E]]
		+	[[Category: Waugh, D S]]
		+	[[Category: Zhao, X Z]]
		+	[[Category: Fragment-based drug design]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 03:59, 20 June 2018

OCA — Wed, 20 Jun 2018 03:59:36 GMT

←Older revision		Revision as of 03:59, 20 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6djd is ON HOLD	+	The entry 6djd is ON HOLD until Paper Publication

	Authors: Lountos, G.T., Zhao, X.Z., Kiselev, E., Tropea, J.E., Needle, D., Burke Jr., T.R., Pommier, Y., Waugh, D.S.		Authors: Lountos, G.T., Zhao, X.Z., Kiselev, E., Tropea, J.E., Needle, D., Burke Jr., T.R., Pommier, Y., Waugh, D.S.

OCA: Protected "6djd" [edit=sysop:move=sysop]

OCA — Wed, 06 Jun 2018 04:18:41 GMT

Protected "6djd" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:18, 6 June 2018

OCA: New page: '''Unreleased structure''' The entry 6djd is ON HOLD Authors: Lountos, G.T., Zhao, X.Z., Kiselev, E., Tropea, J.E., Needle, D., Burke Jr., T.R., Pommier, Y., Waugh, D.S. Description: C...

OCA — Wed, 06 Jun 2018 04:18:40 GMT

New page: '''Unreleased structure''' The entry 6djd is ON HOLD Authors: Lountos, G.T., Zhao, X.Z., Kiselev, E., Tropea, J.E., Needle, D., Burke Jr., T.R., Pommier, Y., Waugh, D.S. Description: C...

New page

'''Unreleased structure'''

The entry 6djd is ON HOLD

Authors: Lountos, G.T., Zhao, X.Z., Kiselev, E., Tropea, J.E., Needle, D., Burke Jr., T.R., Pommier, Y., Waugh, D.S.

Description: Crystal structure of Tdp1 catalytic domain in complex with Zenobia fragment ZT1982 (single soak)
[[Category: Unreleased Structures]]
[[Category: T.R]]
[[Category: Pommier, Y]]
[[Category: Waugh, D.S]]
[[Category: Kiselev, E]]
[[Category: Zhao, X.Z]]
[[Category: Tropea, J.E]]
[[Category: Burke Jr]]
[[Category: Needle, D]]
[[Category: Lountos, G.T]]