6djr - Revision history

OCA at 14:34, 13 March 2024

OCA — Wed, 13 Mar 2024 14:34:57 GMT

←Older revision		Revision as of 14:34, 13 March 2024
Line 3:		Line 3:
	<SX load='6djr' size='340' side='right' viewer='molstar' caption='[[6djr]], [[Resolution\|resolution]] 5.80Å' scene=''>		<SX load='6djr' size='340' side='right' viewer='molstar' caption='[[6djr]], [[Resolution\|resolution]] 5.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6djr]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DJR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6DJR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6djr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DJR FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=UNK:UNKNOWN'>UNK</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 5.8Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6djr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6djr OCA], [~~http~~://pdbe.org/6djr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6djr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6djr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6djr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6djr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6djr OCA], [https://pdbe.org/6djr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6djr RCSB], [https://www.ebi.ac.uk/pdbsum/6djr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6djr ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The transient receptor potential ion channels support Ca(2+) permeation in many organs, including the heart, brain, and kidney. Genetic mutations in transient receptor potential cation channel subfamily C member 3 (TRPC3) are associated with neurodegenerative diseases, memory loss, and hypertension. To better understand the conformational changes that regulate TRPC3 function, we solved the cryo-EM structures for the full-length human TRPC3 and its cytoplasmic domain (CPD) in the apo state at 5.8 and 4.0 A resolution, respectively. These structures revealed that the TRPC3 transmembrane domain resembles those of other TRP channels and that the CPD is a stable module involved in channel assembly and gating. We observed the presence of a C-terminal domain swap at the center of the CPD, where horizontal helices (HHs) transition into a coiled-coil bundle. Comparison of TRPC3 structures revealed that the HHs can reside in two distinct positions. Electrophysiological analyses disclosed that shortening the length of the C-terminal loop connecting the HH with the TRP helices increases TRPC3 activity and that elongating the length of the loop has the opposite effect. Our findings indicate that the C-terminal loop affects channel gating by altering the allosteric coupling between the cytoplasmic and transmembrane domains. We propose that molecules that target the HH may represent a promising strategy for controlling TRPC3-associated neurological disorders and hypertension.
-
-	Structure-function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating.,Sierra-Valdez F, Azumaya CM, Romero LO, Nakagawa T, Cordero-Morales JF J Biol Chem. 2018 Aug 23. pii: RA118.005066. doi: 10.1074/jbc.RA118.005066. PMID:30139744<ref>PMID:30139744</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 6djr" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Azumaya~~, C M~~]]	+	[[Category: Azumaya CM]]
-	[[Category: Cordero-Morales~~, J F~~]]	+	[[Category: Cordero-Morales JF]]
-	[[Category: Nakagawa, T]]	+	[[Category: Nakagawa T]]
-	[[Category: Sierra-Valdez~~, F J]]~~	+	[[Category: Sierra-Valdez FJ]]
-	~~[[Category: Cerebellum]]~~	+
-	~~[[Category: Ion channel]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Moonwalker]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Trp channel~~]]	+

OCA at 00:04, 11 April 2020

OCA — Sat, 11 Apr 2020 00:04:57 GMT

←Older revision		Revision as of 00:04, 11 April 2020
Line 3:		Line 3:
	<SX load='6djr' size='340' side='right' viewer='molstar' caption='[[6djr]], [[Resolution\|resolution]] 5.80Å' scene=''>		<SX load='6djr' size='340' side='right' viewer='molstar' caption='[[6djr]], [[Resolution\|resolution]] 5.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6djr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DJR OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DJR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6djr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DJR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DJR FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6djr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6djr OCA], [http://pdbe.org/6djr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6djr RCSB], [http://www.ebi.ac.uk/pdbsum/6djr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6djr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6djr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6djr OCA], [http://pdbe.org/6djr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6djr RCSB], [http://www.ebi.ac.uk/pdbsum/6djr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6djr ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:54, 6 March 2020

OCA — Fri, 06 Mar 2020 20:54:31 GMT

←Older revision		Revision as of 20:54, 6 March 2020
Line 1:		Line 1:

	==Full-length human TRPC3 in GDN==		==Full-length human TRPC3 in GDN==
-	<~~StructureSection~~ load='6djr' size='340' side='right'caption='[[6djr]], [[Resolution\|resolution]] 5.80Å' scene=''>	+	<SX load='6djr' size='340' side='right' viewer='molstar' caption='[[6djr]], [[Resolution\|resolution]] 5.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6djr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DJR FirstGlance]. <br>		<table><tr><td colspan='2'>[[6djr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DJR FirstGlance]. <br>
Line 19:		Line 19:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 17:54, 11 December 2019

OCA — Wed, 11 Dec 2019 17:54:50 GMT

←Older revision		Revision as of 17:54, 11 December 2019
Line 1:		Line 1:

	==Full-length human TRPC3 in GDN==		==Full-length human TRPC3 in GDN==
-	<StructureSection load='6djr' size='340' side='right' caption='[[6djr]], [[Resolution\|resolution]] 5.80Å' scene=''>	+	<StructureSection load='6djr' size='340' side='right'caption='[[6djr]], [[Resolution\|resolution]] 5.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6djr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DJR FirstGlance]. <br>		<table><tr><td colspan='2'>[[6djr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DJR FirstGlance]. <br>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Azumaya, C M]]		[[Category: Azumaya, C M]]
	[[Category: Cordero-Morales, J F]]		[[Category: Cordero-Morales, J F]]

OCA at 10:29, 5 September 2018

OCA — Wed, 05 Sep 2018 10:29:02 GMT

←Older revision		Revision as of 10:29, 5 September 2018
Line 3:		Line 3:
	<StructureSection load='6djr' size='340' side='right' caption='[[6djr]], [[Resolution\|resolution]] 5.80Å' scene=''>		<StructureSection load='6djr' size='340' side='right' caption='[[6djr]], [[Resolution\|resolution]] 5.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6djr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DJR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6djr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DJR FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6djr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6djr OCA], [http://pdbe.org/6djr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6djr RCSB], [http://www.ebi.ac.uk/pdbsum/6djr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6djr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6djr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6djr OCA], [http://pdbe.org/6djr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6djr RCSB], [http://www.ebi.ac.uk/pdbsum/6djr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6djr ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The transient receptor potential ion channels support Ca(2+) permeation in many organs, including the heart, brain, and kidney. Genetic mutations in transient receptor potential cation channel subfamily C member 3 (TRPC3) are associated with neurodegenerative diseases, memory loss, and hypertension. To better understand the conformational changes that regulate TRPC3 function, we solved the cryo-EM structures for the full-length human TRPC3 and its cytoplasmic domain (CPD) in the apo state at 5.8 and 4.0 A resolution, respectively. These structures revealed that the TRPC3 transmembrane domain resembles those of other TRP channels and that the CPD is a stable module involved in channel assembly and gating. We observed the presence of a C-terminal domain swap at the center of the CPD, where horizontal helices (HHs) transition into a coiled-coil bundle. Comparison of TRPC3 structures revealed that the HHs can reside in two distinct positions. Electrophysiological analyses disclosed that shortening the length of the C-terminal loop connecting the HH with the TRP helices increases TRPC3 activity and that elongating the length of the loop has the opposite effect. Our findings indicate that the C-terminal loop affects channel gating by altering the allosteric coupling between the cytoplasmic and transmembrane domains. We propose that molecules that target the HH may represent a promising strategy for controlling TRPC3-associated neurological disorders and hypertension.
		+
		+	Structure-function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating.,Sierra-Valdez F, Azumaya CM, Romero LO, Nakagawa T, Cordero-Morales JF J Biol Chem. 2018 Aug 23. pii: RA118.005066. doi: 10.1074/jbc.RA118.005066. PMID:30139744<ref>PMID:30139744</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6djr" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Azumaya, C M]]		[[Category: Azumaya, C M]]
	[[Category: Cordero-Morales, J F]]		[[Category: Cordero-Morales, J F]]

OCA at 07:27, 29 August 2018

OCA — Wed, 29 Aug 2018 07:27:45 GMT

←Older revision		Revision as of 07:27, 29 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6djr is ~~ON HOLD until Paper Publication~~	+	==Full-length human TRPC3 in GDN==
-		+	<StructureSection load='6djr' size='340' side='right' caption='[[6djr]], [[Resolution\|resolution]] 5.80Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6djr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DJR FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6djr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6djr OCA], [http://pdbe.org/6djr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6djr RCSB], [http://www.ebi.ac.uk/pdbsum/6djr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6djr ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Azumaya, C M]]
		+	[[Category: Cordero-Morales, J F]]
		+	[[Category: Nakagawa, T]]
		+	[[Category: Sierra-Valdez, F J]]
		+	[[Category: Cerebellum]]
		+	[[Category: Ion channel]]
		+	[[Category: Membrane protein]]
		+	[[Category: Moonwalker]]
		+	[[Category: Transport protein]]
		+	[[Category: Trp channel]]

OCA at 05:38, 14 June 2018

OCA — Thu, 14 Jun 2018 05:38:50 GMT

←Older revision		Revision as of 05:38, 14 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6djr is ON HOLD	+	The entry 6djr is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6djr" [edit=sysop:move=sysop]

OCA — Wed, 06 Jun 2018 04:19:36 GMT

Protected "6djr" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:19, 6 June 2018

OCA: New page: '''Unreleased structure''' The entry 6djr is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 06 Jun 2018 04:19:35 GMT

New page: '''Unreleased structure''' The entry 6djr is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6djr is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]