6dk4 - Revision history

OCA at 14:32, 6 March 2024

OCA — Wed, 06 Mar 2024 14:32:49 GMT

←Older revision		Revision as of 14:32, 6 March 2024
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	<StructureSection load='6dk4' size='340' side='right'caption='[[6dk4]], [[Resolution\|resolution]] 2.71Å' scene=''>		<StructureSection load='6dk4' size='340' side='right'caption='[[6dk4]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dk4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"campylobacter_fetus_subsp._jejuni"_smibert_1974 "campylobacter fetus subsp.~~ jejuni~~" smibert 1974~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DK4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DK4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dk4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni Campylobacter jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DK4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.71Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">perR, fur, Cj0322 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=197 "Campylobacter fetus subsp. jejuni" Smibert 1974])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dk4 OCA], [~~http~~://pdbe.org/6dk4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6dk4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6dk4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6dk4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dk4 OCA], [https://pdbe.org/6dk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dk4 RCSB], [https://www.ebi.ac.uk/pdbsum/6dk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dk4 ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/Q0PBI7_CAMJE Q0PBI7_CAMJE]
-	In Campylobacter jejuni (Cj), the metal-cofactored peroxide response regulator (PerR) transcription factor allows C. jejuni to respond to oxidative stresses. The crystal structure of the metalated form of CjPerR shows that the protein folds as an asymmetric dimer displaying structural differences in the orientation of its DNA-binding domain. Comparative analysis shows that such asymmetry is a conserved feature among crystallized PerR proteins, and mutational analysis reveals that residues found in the first alpha-helix of CjPerR contribute to DNA binding. These studies present the structure of CjPerR protein and highlight structural heterogeneity in the orientation of the metalated PerR DNA-binding domain which may underlie the ability of PerR to recognize DNA, control gene expression and contribute to bacterial pathogenesis. This article is protected by copyright. All rights reserved.	+
-		+
-	~~Crystal structure of Campylobacter jejuni Peroxide Regulator.,Sarvan S, Charih F, Butcher J, Brunzelle JS, Stintzi A, Couture JF FEBS Lett. 2018 Jun 1. doi~~: ~~10.1002~~/~~1873-3468.13120. PMID:29856899<ref>PMID:29856899<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 6dk4" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Campylobacter fetus subsp. jejuni smibert 1974]]
-	[[Category: Large Structures]]
-	[[Category: Brunzelle, J S]]
-	[[Category: Couture, J F]]
-	[[Category: Sarvan, S]]
	[[Category: Campylobacter jejuni]]		[[Category: Campylobacter jejuni]]
-	[[Category: ~~Ferric uptake regulator~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Metal transport~~]]	+	[[Category: Brunzelle JS]]
-	[[Category: ~~Peroxide stress~~]]	+	[[Category: Couture JF]]
-	[[Category: ~~Perr~~]]	+	[[Category: Sarvan S]]

OCA at 08:52, 8 January 2020

OCA — Wed, 08 Jan 2020 08:52:32 GMT

←Older revision		Revision as of 08:52, 8 January 2020
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	==Crystal structure of Campylobacter jejuni peroxide stress regulator==		==Crystal structure of Campylobacter jejuni peroxide stress regulator==
-	<StructureSection load='6dk4' size='340' side='right' caption='[[6dk4]], [[Resolution\|resolution]] 2.71Å' scene=''>	+	<StructureSection load='6dk4' size='340' side='right'caption='[[6dk4]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6dk4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"campylobacter_fetus_subsp._jejuni"_smibert_1974 "campylobacter fetus subsp. jejuni" smibert 1974]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DK4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6dk4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"campylobacter_fetus_subsp._jejuni"_smibert_1974 "campylobacter fetus subsp. jejuni" smibert 1974]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DK4 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Campylobacter fetus subsp. jejuni smibert 1974]]		[[Category: Campylobacter fetus subsp. jejuni smibert 1974]]
		+	[[Category: Large Structures]]
	[[Category: Brunzelle, J S]]		[[Category: Brunzelle, J S]]
	[[Category: Couture, J F]]		[[Category: Couture, J F]]

OCA at 07:52, 12 September 2018

OCA — Wed, 12 Sep 2018 07:52:31 GMT

←Older revision		Revision as of 07:52, 12 September 2018
Line 3:		Line 3:
	<StructureSection load='6dk4' size='340' side='right' caption='[[6dk4]], [[Resolution\|resolution]] 2.71Å' scene=''>		<StructureSection load='6dk4' size='340' side='right' caption='[[6dk4]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dk4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DK4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dk4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"campylobacter_fetus_subsp._jejuni"_smibert_1974 "campylobacter fetus subsp. jejuni" smibert 1974]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DK4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">perR, fur, Cj0322 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=197 "Campylobacter fetus subsp. jejuni" Smibert 1974])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dk4 OCA], [http://pdbe.org/6dk4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dk4 RCSB], [http://www.ebi.ac.uk/pdbsum/6dk4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dk4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dk4 OCA], [http://pdbe.org/6dk4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dk4 RCSB], [http://www.ebi.ac.uk/pdbsum/6dk4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dk4 ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Campylobacter fetus subsp. jejuni smibert 1974]]
	[[Category: Brunzelle, J S]]		[[Category: Brunzelle, J S]]
	[[Category: Couture, J F]]		[[Category: Couture, J F]]

OCA at 07:41, 14 June 2018

OCA — Thu, 14 Jun 2018 07:41:00 GMT

←Older revision		Revision as of 07:41, 14 June 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6dk4 is ~~ON HOLD~~	+	==Crystal structure of Campylobacter jejuni peroxide stress regulator==
		+	<StructureSection load='6dk4' size='340' side='right' caption='[[6dk4]], [[Resolution\|resolution]] 2.71Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6dk4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DK4 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dk4 OCA], [http://pdbe.org/6dk4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dk4 RCSB], [http://www.ebi.ac.uk/pdbsum/6dk4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dk4 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In Campylobacter jejuni (Cj), the metal-cofactored peroxide response regulator (PerR) transcription factor allows C. jejuni to respond to oxidative stresses. The crystal structure of the metalated form of CjPerR shows that the protein folds as an asymmetric dimer displaying structural differences in the orientation of its DNA-binding domain. Comparative analysis shows that such asymmetry is a conserved feature among crystallized PerR proteins, and mutational analysis reveals that residues found in the first alpha-helix of CjPerR contribute to DNA binding. These studies present the structure of CjPerR protein and highlight structural heterogeneity in the orientation of the metalated PerR DNA-binding domain which may underlie the ability of PerR to recognize DNA, control gene expression and contribute to bacterial pathogenesis. This article is protected by copyright. All rights reserved.

-	~~Authors: Sarvan~~, S., ~~Brunzelle~~, J~~.S.~~, ~~Couture~~, J.F.	+	Crystal structure of Campylobacter jejuni Peroxide Regulator.,Sarvan S, Charih F, Butcher J, Brunzelle JS, Stintzi A, Couture JF FEBS Lett. 2018 Jun 1. doi: 10.1002/1873-3468.13120. PMID:29856899<ref>PMID:29856899</ref>

-	~~Description: Crystal structure~~ of ~~Campylobacter jejuni peroxide stress regulator~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: Couture, J.F]]	+	<div class="pdbe-citations 6dk4" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Brunzelle, J S]]
		+	[[Category: Couture, J F]]
	[[Category: Sarvan, S]]		[[Category: Sarvan, S]]
-	[[Category: ~~Brunzelle, J.S~~]]	+	[[Category: Campylobacter jejuni]]
		+	[[Category: Ferric uptake regulator]]
		+	[[Category: Metal transport]]
		+	[[Category: Peroxide stress]]
		+	[[Category: Perr]]

OCA: Protected "6dk4" [edit=sysop:move=sysop]

OCA — Wed, 06 Jun 2018 04:21:32 GMT

Protected "6dk4" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:21, 6 June 2018

OCA: New page: '''Unreleased structure''' The entry 6dk4 is ON HOLD Authors: Sarvan, S., Brunzelle, J.S., Couture, J.F. Description: Crystal structure of Campylobacter jejuni peroxide stress regulato...

OCA — Wed, 06 Jun 2018 04:21:31 GMT

New page: '''Unreleased structure''' The entry 6dk4 is ON HOLD Authors: Sarvan, S., Brunzelle, J.S., Couture, J.F. Description: Crystal structure of Campylobacter jejuni peroxide stress regulato...

New page

'''Unreleased structure'''

The entry 6dk4 is ON HOLD

Authors: Sarvan, S., Brunzelle, J.S., Couture, J.F.

Description: Crystal structure of Campylobacter jejuni peroxide stress regulator
[[Category: Unreleased Structures]]
[[Category: Couture, J.F]]
[[Category: Sarvan, S]]
[[Category: Brunzelle, J.S]]