6dl1 - Revision history

OCA at 11:04, 1 January 2020

OCA — Wed, 01 Jan 2020 11:04:44 GMT

←Older revision		Revision as of 11:04, 1 January 2020
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	==Racemic structure of jatrophidin, an orbitide from Jatropha curcas==		==Racemic structure of jatrophidin, an orbitide from Jatropha curcas==
-	<StructureSection load='6dl1' size='340' side='right' caption='[[6dl1]], [[Resolution\|resolution]] 1.03Å' scene=''>	+	<StructureSection load='6dl1' size='340' side='right'caption='[[6dl1]], [[Resolution\|resolution]] 1.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6dl1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DL1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6dl1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DL1 FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: King, G J]]		[[Category: King, G J]]
	[[Category: Ramalho, S D]]		[[Category: Ramalho, S D]]

OCA at 08:15, 14 November 2018

OCA — Wed, 14 Nov 2018 08:15:13 GMT

←Older revision		Revision as of 08:15, 14 November 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6dl1 is ~~ON HOLD until Paper~~ Publication	+	==Racemic structure of jatrophidin, an orbitide from Jatropha curcas==
		+	<StructureSection load='6dl1' size='340' side='right' caption='[[6dl1]], [[Resolution\|resolution]] 1.03Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6dl1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DL1 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dl1 OCA], [http://pdbe.org/6dl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dl1 RCSB], [http://www.ebi.ac.uk/pdbsum/6dl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dl1 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Orbitides are small cyclic peptides with a diverse range of therapeutic bioactivities. They are produced by many plant species, including those of the Jatropha genus. Here, the objective was to provide new structural information on orbitides to complement the growing knowledge base on orbitide sequences and activities by focusing on three Jatropha orbitides: ribifolin (1), pohlianin C (7), and jatrophidin (12). To determine three-dimensional structures, racemic crystallography, an emerging structural technique that enables rapid crystallization of biomolecules by combining equal amounts of the two enantiomers, was used. The high-resolution structure of ribifolin (0.99 A) was elucidated from its racemate and showed it was identical to the structure crystallized from its l-enantiomer only (1.35 A). Racemic crystallography was also used to elucidate high-resolution structures of pohlianin C (1.20 A) and jatrophidin (1.03 A), for which there was difficulty forming crystals without using racemic mixtures. The structures were used to interpret membrane permeability data in PAMPA and a Caco-2 cell assay, showing they had poor permeability. Overall, the results show racemic crystallography can be used to obtain high-resolution structures of orbitides and is useful when enantiopure samples are difficult to crystallize or solution structures from NMR are of low resolution.

-	~~Authors: Wang~~, ~~C.K~~., King, ~~G.J.~~, ~~Ramalho~~, S.D.	+	Synthesis, Racemic X-ray Crystallographic, and Permeability Studies of Bioactive Orbitides from Jatropha Species.,Ramalho SD, Wang CK, King GJ, Byriel KA, Huang YH, Bolzani VS, Craik DJ J Nat Prod. 2018 Oct 22. doi: 10.1021/acs.jnatprod.8b00447. PMID:30345754<ref>PMID:30345754</ref>

-	~~Description: Racemic structure~~ of ~~jatrophidin~~, ~~an orbitide from Jatropha curcas~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: Wang, C.K]]	+	<div class="pdbe-citations 6dl1" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Ramalho, S.D~~]]	+	== References ==
-	[[Category: ~~King, G.J~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: King, G J]]
		+	[[Category: Ramalho, S D]]
		+	[[Category: Wang, C K]]
		+	[[Category: Cyclic peptide]]
		+	[[Category: Plant protein]]

OCA at 04:37, 22 August 2018

OCA — Wed, 22 Aug 2018 04:37:51 GMT

←Older revision		Revision as of 04:37, 22 August 2018
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	The entry 6dl1 is ON HOLD until Paper Publication		The entry 6dl1 is ON HOLD until Paper Publication

-	Authors: Wang, C.K~~., Ramalho, S.D~~., King, G.J., ~~Craik~~, D.J.	+	Authors: Wang, C.K., King, G.J., Ramalho, S.D.

	Description: Racemic structure of jatrophidin, an orbitide from Jatropha curcas		Description: Racemic structure of jatrophidin, an orbitide from Jatropha curcas
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Wang, C.K]]		[[Category: Wang, C.K]]
-	[[Category: Craik, D.J]]
	[[Category: Ramalho, S.D]]		[[Category: Ramalho, S.D]]
	[[Category: King, G.J]]		[[Category: King, G.J]]

OCA at 05:39, 14 June 2018

OCA — Thu, 14 Jun 2018 05:39:40 GMT

←Older revision		Revision as of 05:39, 14 June 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dl1 is ON HOLD	+	The entry 6dl1 is ON HOLD until Paper Publication

	Authors: Wang, C.K., Ramalho, S.D., King, G.J., Craik, D.J.		Authors: Wang, C.K., Ramalho, S.D., King, G.J., Craik, D.J.

OCA: Protected "6dl1" [edit=sysop:move=sysop]

OCA — Wed, 06 Jun 2018 04:25:00 GMT

Protected "6dl1" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:25, 6 June 2018

OCA: New page: '''Unreleased structure''' The entry 6dl1 is ON HOLD Authors: Wang, C.K., Ramalho, S.D., King, G.J., Craik, D.J. Description: Racemic structure of jatrophidin, an orbitide from Jatroph...

OCA — Wed, 06 Jun 2018 04:24:59 GMT

New page: '''Unreleased structure''' The entry 6dl1 is ON HOLD Authors: Wang, C.K., Ramalho, S.D., King, G.J., Craik, D.J. Description: Racemic structure of jatrophidin, an orbitide from Jatroph...

New page

'''Unreleased structure'''

The entry 6dl1 is ON HOLD

Authors: Wang, C.K., Ramalho, S.D., King, G.J., Craik, D.J.

Description: Racemic structure of jatrophidin, an orbitide from Jatropha curcas
[[Category: Unreleased Structures]]
[[Category: Wang, C.K]]
[[Category: Craik, D.J]]
[[Category: Ramalho, S.D]]
[[Category: King, G.J]]