6dla - Revision history

OCA at 06:08, 11 October 2023

OCA — Wed, 11 Oct 2023 06:08:53 GMT

←Older revision		Revision as of 06:08, 11 October 2023
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	<StructureSection load='6dla' size='340' side='right'caption='[[6dla]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6dla' size='340' side='right'caption='[[6dla]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dla]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6DLA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dla]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DLA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.004Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6dla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dla OCA], [~~http~~://pdbe.org/6dla PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6dla RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6dla PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6dla ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dla OCA], [https://pdbe.org/6dla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dla RCSB], [https://www.ebi.ac.uk/pdbsum/6dla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dla ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Crowe~~, J E~~]]	+	[[Category: Crowe JE]]
-	[[Category: Dong, J]]	+	[[Category: Dong J]]
-	[[Category: Finn~~, J A]]~~	+	[[Category: Finn JA]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Antibody design]]~~	+
-	~~[[Category: Hemagglutinin]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Influenza a virus]]~~	+
-	~~[[Category: Rosetta~~]]	+

OCA at 12:39, 16 December 2020

OCA — Wed, 16 Dec 2020 12:39:12 GMT

←Older revision		Revision as of 12:39, 16 December 2020
Line 3:		Line 3:
	<StructureSection load='6dla' size='340' side='right'caption='[[6dla]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6dla' size='340' side='right'caption='[[6dla]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dla]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLA OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DLA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dla]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DLA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dla OCA], [http://pdbe.org/6dla PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dla RCSB], [http://www.ebi.ac.uk/pdbsum/6dla PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dla ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6dla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dla OCA], [http://pdbe.org/6dla PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dla RCSB], [http://www.ebi.ac.uk/pdbsum/6dla PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dla ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The amount of antibody (Ab) variable gene sequence information is expanding rapidly, but our ability to predict the function of Abs from sequence alone is limited. Here, we describe a sequence-to-function prediction method that couples structural data for a single Ab/antigen (Ag) complex with repertoire data. We used a position-specific structure-scoring matrix (P3SM) incorporating structure-prediction scores from Rosetta to identify Ab variable loops that have predicted structural similarity to the influenza virus-specific human Ab CH65. The P3SM approach identified new members of this Ab class. Recombinant Ab expression, crystallography, and virus inhibition assays showed that the HCDR3 loops of the newly identified Abs possessed similar structure and antiviral activity as the comparator CH65. This approach enables discovery of new human Abs with desired structure and function using cDNA repertoires that are obtained readily with current amplicon sequencing techniques.
		+
		+	Identification of Structurally Related Antibodies in Antibody Sequence Databases Using Rosetta-Derived Position-Specific Scoring.,Finn JA, Dong J, Sevy AM, Parrish E, Gilchuk I, Nargi R, Scarlett-Jones M, Reichard W, Bombardi R, Voss TG, Meiler J, Crowe JE Jr Structure. 2020 Oct 6;28(10):1124-1130.e5. doi: 10.1016/j.str.2020.07.012. Epub, 2020 Aug 11. PMID:32783953<ref>PMID:32783953</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6dla" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Crowe, J E]]		[[Category: Crowe, J E]]

OCA at 22:41, 5 June 2019

OCA — Wed, 05 Jun 2019 22:41:53 GMT

←Older revision		Revision as of 22:41, 5 June 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6dla ~~is ON HOLD until Paper Publication~~	+	==Crystal structures of an influenza A hemagglutinin antibody Fab CH65:7969d2==
-		+	<StructureSection load='6dla' size='340' side='right'caption='[[6dla]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6dla]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLA FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dla OCA], [http://pdbe.org/6dla PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dla RCSB], [http://www.ebi.ac.uk/pdbsum/6dla PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dla ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Crowe, J E]]
		+	[[Category: Dong, J]]
		+	[[Category: Finn, J A]]
		+	[[Category: Antibody]]
		+	[[Category: Antibody design]]
		+	[[Category: Hemagglutinin]]
		+	[[Category: Immune system]]
		+	[[Category: Influenza a virus]]
		+	[[Category: Rosetta]]

OCA at 05:39, 14 June 2018

OCA — Thu, 14 Jun 2018 05:39:53 GMT

←Older revision		Revision as of 05:39, 14 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dla is ON HOLD	+	The entry 6dla is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6dla" [edit=sysop:move=sysop]

OCA — Wed, 06 Jun 2018 04:25:45 GMT

Protected "6dla" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:25, 6 June 2018

OCA: New page: '''Unreleased structure''' The entry 6dla is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 06 Jun 2018 04:25:44 GMT

New page: '''Unreleased structure''' The entry 6dla is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6dla is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]