6dlv - Revision history

OCA at 14:35, 13 March 2024

OCA — Wed, 13 Mar 2024 14:35:30 GMT

←Older revision		Revision as of 14:35, 13 March 2024
Line 3:		Line 3:
	<SX load='6dlv' size='340' side='right' viewer='molstar' caption='[[6dlv]], [[Resolution\|resolution]] 10.10Å' scene=''>		<SX load='6dlv' size='340' side='right' viewer='molstar' caption='[[6dlv]], [[Resolution\|resolution]] 10.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dlv]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6DLV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dlv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DLV FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[6dlu\|6dlu]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 10.1Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">DNM1, DNM ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlv OCA], [https://pdbe.org/6dlv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dlv RCSB], [https://www.ebi.ac.uk/pdbsum/6dlv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlv ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6dlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlv OCA], [~~http~~://pdbe.org/6dlv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6dlv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6dlv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlv ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN]] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.	+	[https://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Membrane fission is a fundamental process in the regulation and remodelling of cell membranes. Dynamin, a large GTPase, mediates membrane fission by assembling around, constricting and cleaving the necks of budding vesicles(1). Here we report a 3.75 A resolution cryo-electron microscopy structure of the membrane-associated helical polymer of human dynamin-1 in the GMPPCP-bound state. The structure defines the helical symmetry of the dynamin polymer and the positions of its oligomeric interfaces, which were validated by cell-based endocytosis assays. Compared to the lipid-free tetramer form(2), membrane-associated dynamin binds to the lipid bilayer with its pleckstrin homology domain (PHD) and self-assembles across the helical rungs via its guanine nucleotide-binding (GTPase) domain(3). Notably, interaction with the membrane and helical assembly are accommodated by a severely bent bundle signalling element (BSE), which connects the GTPase domain to the rest of the protein. The BSE conformation is asymmetric across the inter-rung GTPase interface, and is unique compared to all known nucleotide-bound states of dynamin. The structure suggests that the BSE bends as a result of forces generated from the GTPase dimer interaction that are transferred across the stalk to the PHD and lipid membrane. Mutations that disrupted the BSE kink impaired endocytosis. We also report a 10.1 A resolution cryo-electron microscopy map of a super-constricted dynamin polymer showing localized conformational changes at the BSE and GTPase domains, induced by GTP hydrolysis, that drive membrane constriction. Together, our results provide a structural basis for the mechanism of action of dynamin on the lipid membrane.	+
-		+
-	Cryo-EM of the dynamin polymer assembled on lipid membrane.,Kong L, Sochacki KA, Wang H, Fang S, Canagarajah B, Kehr AD, Rice WJ, Strub MP, Taraska JW, Hinshaw JE Nature. 2018 Aug;560(7717):258-262. doi: 10.1038/s41586-018-0378-6. Epub 2018 Aug, 1. PMID:30069048<ref>PMID:30069048</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 6dlv" style="background-color:#fffaf0;"></div>~~	+
-		+
-	~~==See Also==~~	+
-	*[[Dynamin 3D structures\|Dynamin 3D structures]]	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: ~~Dynamin GTPase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Canagarajah, B]]	+	[[Category: Canagarajah B]]
-	[[Category: Fang, S]]	+	[[Category: Fang S]]
-	[[Category: Hinshaw~~, J E~~]]	+	[[Category: Hinshaw JE]]
-	[[Category: Kehr~~, A D~~]]	+	[[Category: Kehr AD]]
-	[[Category: Kong, L]]	+	[[Category: Kong L]]
-	[[Category: Rice~~, W J~~]]	+	[[Category: Rice WJ]]
-	[[Category: Wang, H]]	+	[[Category: Wang H]]
-	~~[[Category: Dynamin family]]~~	+
-	~~[[Category: Endocytosis]]~~	+
-	~~[[Category: Gtpase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Pleckstrin homology domain~~]]	+

OCA at 00:06, 11 April 2020

OCA — Sat, 11 Apr 2020 00:06:13 GMT

←Older revision		Revision as of 00:06, 11 April 2020
Line 3:		Line 3:
	<SX load='6dlv' size='340' side='right' viewer='molstar' caption='[[6dlv]], [[Resolution\|resolution]] 10.10Å' scene=''>		<SX load='6dlv' size='340' side='right' viewer='molstar' caption='[[6dlv]], [[Resolution\|resolution]] 10.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dlv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DLV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dlv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DLV FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6dlu\|6dlu]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6dlu\|6dlu]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DNM1, DNM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DNM1, DNM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlv OCA], [http://pdbe.org/6dlv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlv RCSB], [http://www.ebi.ac.uk/pdbsum/6dlv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6dlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlv OCA], [http://pdbe.org/6dlv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlv RCSB], [http://www.ebi.ac.uk/pdbsum/6dlv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 20:55, 6 March 2020

OCA — Fri, 06 Mar 2020 20:55:12 GMT

←Older revision		Revision as of 20:55, 6 March 2020
Line 1:		Line 1:

	==Cryo-EM of the GTP-bound human dynamin-1 polymer assembled on the membrane in the super constricted state==		==Cryo-EM of the GTP-bound human dynamin-1 polymer assembled on the membrane in the super constricted state==
-	<~~StructureSection~~ load='6dlv' size='340' side='right'caption='[[6dlv]], [[Resolution\|resolution]] 10.10Å' scene=''>	+	<SX load='6dlv' size='340' side='right' viewer='molstar' caption='[[6dlv]], [[Resolution\|resolution]] 10.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6dlv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLV FirstGlance]. <br>		<table><tr><td colspan='2'>[[6dlv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLV FirstGlance]. <br>
Line 26:		Line 26:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Dynamin GTPase]]		[[Category: Dynamin GTPase]]
	[[Category: Human]]		[[Category: Human]]

OCA at 08:53, 8 January 2020

OCA — Wed, 08 Jan 2020 08:53:20 GMT

←Older revision		Revision as of 08:53, 8 January 2020
Line 1:		Line 1:

	==Cryo-EM of the GTP-bound human dynamin-1 polymer assembled on the membrane in the super constricted state==		==Cryo-EM of the GTP-bound human dynamin-1 polymer assembled on the membrane in the super constricted state==
-	<StructureSection load='6dlv' size='340' side='right' caption='[[6dlv]], [[Resolution\|resolution]] 10.10Å' scene=''>	+	<StructureSection load='6dlv' size='340' side='right'caption='[[6dlv]], [[Resolution\|resolution]] 10.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6dlv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLV FirstGlance]. <br>		<table><tr><td colspan='2'>[[6dlv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLV FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 6dlv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6dlv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dynamin 3D structures\|Dynamin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 29:
	[[Category: Dynamin GTPase]]		[[Category: Dynamin GTPase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Canagarajah, B]]		[[Category: Canagarajah, B]]
	[[Category: Fang, S]]		[[Category: Fang, S]]

OCA at 16:40, 15 August 2018

OCA — Wed, 15 Aug 2018 16:40:00 GMT

←Older revision		Revision as of 16:40, 15 August 2018
Line 3:		Line 3:
	<StructureSection load='6dlv' size='340' side='right' caption='[[6dlv]], [[Resolution\|resolution]] 10.10Å' scene=''>		<StructureSection load='6dlv' size='340' side='right' caption='[[6dlv]], [[Resolution\|resolution]] 10.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dlv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dlv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLV FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6dlu\|6dlu]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6dlu\|6dlu]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DNM1, DNM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlv OCA], [http://pdbe.org/6dlv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlv RCSB], [http://www.ebi.ac.uk/pdbsum/6dlv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlv OCA], [http://pdbe.org/6dlv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlv RCSB], [http://www.ebi.ac.uk/pdbsum/6dlv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlv ProSAT]</span></td></tr>
Line 10:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN]] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.		[[http://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN]] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Membrane fission is a fundamental process in the regulation and remodelling of cell membranes. Dynamin, a large GTPase, mediates membrane fission by assembling around, constricting and cleaving the necks of budding vesicles(1). Here we report a 3.75 A resolution cryo-electron microscopy structure of the membrane-associated helical polymer of human dynamin-1 in the GMPPCP-bound state. The structure defines the helical symmetry of the dynamin polymer and the positions of its oligomeric interfaces, which were validated by cell-based endocytosis assays. Compared to the lipid-free tetramer form(2), membrane-associated dynamin binds to the lipid bilayer with its pleckstrin homology domain (PHD) and self-assembles across the helical rungs via its guanine nucleotide-binding (GTPase) domain(3). Notably, interaction with the membrane and helical assembly are accommodated by a severely bent bundle signalling element (BSE), which connects the GTPase domain to the rest of the protein. The BSE conformation is asymmetric across the inter-rung GTPase interface, and is unique compared to all known nucleotide-bound states of dynamin. The structure suggests that the BSE bends as a result of forces generated from the GTPase dimer interaction that are transferred across the stalk to the PHD and lipid membrane. Mutations that disrupted the BSE kink impaired endocytosis. We also report a 10.1 A resolution cryo-electron microscopy map of a super-constricted dynamin polymer showing localized conformational changes at the BSE and GTPase domains, induced by GTP hydrolysis, that drive membrane constriction. Together, our results provide a structural basis for the mechanism of action of dynamin on the lipid membrane.
		+
		+	Cryo-EM of the dynamin polymer assembled on lipid membrane.,Kong L, Sochacki KA, Wang H, Fang S, Canagarajah B, Kehr AD, Rice WJ, Strub MP, Taraska JW, Hinshaw JE Nature. 2018 Aug;560(7717):258-262. doi: 10.1038/s41586-018-0378-6. Epub 2018 Aug, 1. PMID:30069048<ref>PMID:30069048</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6dlv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Dynamin GTPase]]		[[Category: Dynamin GTPase]]
		+	[[Category: Human]]
	[[Category: Canagarajah, B]]		[[Category: Canagarajah, B]]
	[[Category: Fang, S]]		[[Category: Fang, S]]

OCA at 18:50, 1 August 2018

OCA — Wed, 01 Aug 2018 18:50:49 GMT

←Older revision		Revision as of 18:50, 1 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6dlv is ~~ON HOLD~~	+	==Cryo-EM of the GTP-bound human dynamin-1 polymer assembled on the membrane in the super constricted state==
-		+	<StructureSection load='6dlv' size='340' side='right' caption='[[6dlv]], [[Resolution\|resolution]] 10.10Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6dlv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLV FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6dlu\|6dlu]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dynamin_GTPase Dynamin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.5 3.6.5.5] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlv OCA], [http://pdbe.org/6dlv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlv RCSB], [http://www.ebi.ac.uk/pdbsum/6dlv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlv ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN]] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dynamin GTPase]]
		+	[[Category: Canagarajah, B]]
		+	[[Category: Fang, S]]
		+	[[Category: Hinshaw, J E]]
		+	[[Category: Kehr, A D]]
		+	[[Category: Kong, L]]
		+	[[Category: Rice, W J]]
		+	[[Category: Wang, H]]
		+	[[Category: Dynamin family]]
		+	[[Category: Endocytosis]]
		+	[[Category: Gtpase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Membrane protein]]
		+	[[Category: Pleckstrin homology domain]]

OCA: Protected "6dlv" [edit=sysop:move=sysop]

OCA — Thu, 14 Jun 2018 05:41:18 GMT

Protected "6dlv" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:41, 14 June 2018

OCA: New page: '''Unreleased structure''' The entry 6dlv is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 14 Jun 2018 05:41:16 GMT

New page: '''Unreleased structure''' The entry 6dlv is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6dlv is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]