6dlx - Revision history

OCA at 06:09, 11 October 2023

OCA — Wed, 11 Oct 2023 06:09:10 GMT

←Older revision		Revision as of 06:09, 11 October 2023
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	<StructureSection load='6dlx' size='340' side='right'caption='[[6dlx]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='6dlx' size='340' side='right'caption='[[6dlx]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dlx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6DLX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dlx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DLX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GXY:4-bromo-2,5-dimethoxyaniline'>GXY</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.848Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6dlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlx OCA], [~~http~~://pdbe.org/6dlx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6dlx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6dlx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlx ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GXY:4-bromo-2,5-dimethoxyaniline'>GXY</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlx OCA], [https://pdbe.org/6dlx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dlx RCSB], [https://www.ebi.ac.uk/pdbsum/6dlx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlx ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FTSY_ECOLI FTSY_ECOLI] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.<ref>PMID:8194520</ref> <ref>PMID:9305630</ref> <ref>PMID:11735405</ref> <ref>PMID:11741850</ref> <ref>PMID:15148364</ref> <ref>PMID:17682051</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ataide~~, F S~~]]	+	[[Category: Ataide FS]]
-	[[Category: Faoro, C]]	+	[[Category: Faoro C]]
-	~~[[Category: Fbdd]]~~	+
-	~~[[Category: Ftsy]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Sr receptor]]~~	+
-	~~[[Category: Srp~~]]	+

OCA at 09:05, 11 November 2020

OCA — Wed, 11 Nov 2020 09:05:46 GMT

←Older revision		Revision as of 09:05, 11 November 2020
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	==FtsY-NG domain bound to fragment 3.==		==FtsY-NG domain bound to fragment 3.==
-	<StructureSection load='6dlx' size='340' side='right' caption='[[6dlx]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='6dlx' size='340' side='right'caption='[[6dlx]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dlx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLX OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DLX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dlx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DLX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GXY:4-bromo-2,5-dimethoxyaniline'>GXY</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GXY:4-bromo-2,5-dimethoxyaniline'>GXY</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlx OCA], [http://pdbe.org/6dlx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlx RCSB], [http://www.ebi.ac.uk/pdbsum/6dlx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6dlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlx OCA], [http://pdbe.org/6dlx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlx RCSB], [http://www.ebi.ac.uk/pdbsum/6dlx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlx ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 6dlx" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6dlx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Signal recognition particle receptor\|Signal recognition particle receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ataide, F S]]		[[Category: Ataide, F S]]
	[[Category: Faoro, C]]		[[Category: Faoro, C]]

OCA at 06:08, 22 August 2018

OCA — Wed, 22 Aug 2018 06:08:43 GMT

←Older revision		Revision as of 06:08, 22 August 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6dlx is ~~ON HOLD until Paper~~ Publication	+	==FtsY-NG domain bound to fragment 3.==
		+	<StructureSection load='6dlx' size='340' side='right' caption='[[6dlx]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6dlx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GXY:4-bromo-2,5-dimethoxyaniline'>GXY</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlx OCA], [http://pdbe.org/6dlx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlx RCSB], [http://www.ebi.ac.uk/pdbsum/6dlx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlx ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Given the increasing incidence of antibiotic resistance, antibiotics that employ new strategies are urgently needed. Bacterial survival is dependent on proper function of the signal recognition particle (SRP) and its receptor (FtsY). A unique set of interactions in FtsY:SRP-RNA represents a promising candidate for new antibiotic development as no antibiotic targets this complex and these interactions are functionally replaced by protein:protein interactions in eukaryotes. We used a Fragment Based Drug Design (FBDD) approach to search for new compounds that can bind FtsY, and have identified three lead fragments. In vitro and in vivo analyses have shown that despite a high micromolar binding affinity, one fragment has some antimicrobial properties. X-ray structures of E. coli FtsY:fragments reveal the fragments bind in the targeted RNA interaction site. Our results show that FBDD is a suitable approach for targeting FtsY:SRP-RNA for antibiotic development and opens the possibility of targeting protein:RNA interactions in general.

-	~~Authors: Ataide, F.S~~., Faoro, C.	+	Discovery of fragments that target key interactions in the signal recognition particle (SRP) as potential leads for a new class of antibiotics.,Faoro C, Wilkinson-White L, Kwan AH, Ataide SF PLoS One. 2018 Jul 25;13(7):e0200387. doi: 10.1371/journal.pone.0200387., eCollection 2018. PMID:30044812<ref>PMID:30044812</ref>

-	~~Description: FtsY-NG domain bound to fragment 3~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6dlx" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ataide, F S]]
	[[Category: Faoro, C]]		[[Category: Faoro, C]]
-	[[Category: ~~Ataide, F.S~~]]	+	[[Category: Fbdd]]
		+	[[Category: Ftsy]]
		+	[[Category: Signaling protein]]
		+	[[Category: Sr receptor]]
		+	[[Category: Srp]]

OCA at 05:37, 4 July 2018

OCA — Wed, 04 Jul 2018 05:37:11 GMT

←Older revision		Revision as of 05:37, 4 July 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dlx is ON HOLD	+	The entry 6dlx is ON HOLD until Paper Publication

	Authors: Ataide, F.S., Faoro, C.		Authors: Ataide, F.S., Faoro, C.

OCA: Protected "6dlx" [edit=sysop:move=sysop]

OCA — Thu, 14 Jun 2018 05:41:25 GMT

Protected "6dlx" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:41, 14 June 2018

OCA: New page: '''Unreleased structure''' The entry 6dlx is ON HOLD Authors: Ataide, F.S., Faoro, C. Description: FtsY-NG domain bound to fragment 3. Category: Unreleased Structures [[Category: F...

OCA — Thu, 14 Jun 2018 05:41:23 GMT

New page: '''Unreleased structure''' The entry 6dlx is ON HOLD Authors: Ataide, F.S., Faoro, C. Description: FtsY-NG domain bound to fragment 3. Category: Unreleased Structures [[Category: F...

New page

'''Unreleased structure'''

The entry 6dlx is ON HOLD

Authors: Ataide, F.S., Faoro, C.

Description: FtsY-NG domain bound to fragment 3.
[[Category: Unreleased Structures]]
[[Category: Faoro, C]]
[[Category: Ataide, F.S]]