6dlz - Revision history

OCA at 00:06, 11 April 2020

OCA — Sat, 11 Apr 2020 00:06:37 GMT

←Older revision		Revision as of 00:06, 11 April 2020
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	<SX load='6dlz' size='340' side='right' viewer='molstar' caption='[[6dlz]], [[Resolution\|resolution]] 3.90Å' scene=''>		<SX load='6dlz' size='340' side='right' viewer='molstar' caption='[[6dlz]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dlz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DLZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dlz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DLZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYZ:CYCLOTHIAZIDE'>CYZ</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYZ:CYCLOTHIAZIDE'>CYZ</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CACNG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CACNG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlz OCA], [http://pdbe.org/6dlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlz RCSB], [http://www.ebi.ac.uk/pdbsum/6dlz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6dlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlz OCA], [http://pdbe.org/6dlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlz RCSB], [http://www.ebi.ac.uk/pdbsum/6dlz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 20:55, 6 March 2020

OCA — Fri, 06 Mar 2020 20:55:20 GMT

←Older revision		Revision as of 20:55, 6 March 2020
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	==Open state GluA2 in complex with STZ after micelle signal subtraction==		==Open state GluA2 in complex with STZ after micelle signal subtraction==
-	<~~StructureSection~~ load='6dlz' size='340' side='right'caption='[[6dlz]], [[Resolution\|resolution]] 3.90Å' scene=''>	+	<SX load='6dlz' size='340' side='right' viewer='molstar' caption='[[6dlz]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6dlz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[6dlz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLZ FirstGlance]. <br>
Line 22:		Line 22:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 10:08, 4 December 2019

OCA — Wed, 04 Dec 2019 10:08:16 GMT

←Older revision		Revision as of 10:08, 4 December 2019
Line 1:		Line 1:

	==Open state GluA2 in complex with STZ after micelle signal subtraction==		==Open state GluA2 in complex with STZ after micelle signal subtraction==
-	<StructureSection load='6dlz' size='340' side='right' caption='[[6dlz]], [[Resolution\|resolution]] 3.90Å' scene=''>	+	<StructureSection load='6dlz' size='340' side='right'caption='[[6dlz]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6dlz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[6dlz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLZ FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Sobolevsky, A I]]		[[Category: Sobolevsky, A I]]
	[[Category: Twomey, E C]]		[[Category: Twomey, E C]]

OCA at 10:29, 5 September 2018

OCA — Wed, 05 Sep 2018 10:29:09 GMT

←Older revision		Revision as of 10:29, 5 September 2018
Line 3:		Line 3:
	<StructureSection load='6dlz' size='340' side='right' caption='[[6dlz]], [[Resolution\|resolution]] 3.90Å' scene=''>		<StructureSection load='6dlz' size='340' side='right' caption='[[6dlz]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dlz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dlz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYZ:CYCLOTHIAZIDE'>CYZ</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYZ:CYCLOTHIAZIDE'>CYZ</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CACNG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlz OCA], [http://pdbe.org/6dlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlz RCSB], [http://www.ebi.ac.uk/pdbsum/6dlz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlz OCA], [http://pdbe.org/6dlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlz RCSB], [http://www.ebi.ac.uk/pdbsum/6dlz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>		[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	AMPA receptors mediate fast excitatory neurotransmission and are critical for CNS development and function. Calcium-permeable subsets of AMPA receptors are strongly implicated in acute and chronic neurological disorders. However, despite the clinical importance, the therapeutic landscape for specifically targeting them, and not the calcium-impermeable AMPA receptors, remains largely undeveloped. To address this problem, we used cryo-electron microscopy and electrophysiology to investigate the mechanisms by which small-molecule blockers selectively inhibit ion channel conductance in calcium-permeable AMPA receptors. We determined the structures of calcium-permeable GluA2 AMPA receptor complexes with the auxiliary subunit stargazin bound to channel blockers, including the orb weaver spider toxin AgTx-636, the spider toxin analog NASPM, and the adamantane derivative IEM-1460. Our structures provide insights into the architecture of the blocker binding site and the mechanism of trapping, which are critical for development of small molecules that specifically target calcium-permeable AMPA receptors.
		+
		+	Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors.,Twomey EC, Yelshanskaya MV, Vassilevski AA, Sobolevsky AI Neuron. 2018 Aug 9. pii: S0896-6273(18)30625-1. doi:, 10.1016/j.neuron.2018.07.027. PMID:30122377<ref>PMID:30122377</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6dlz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Sobolevsky, A I]]		[[Category: Sobolevsky, A I]]
	[[Category: Twomey, E C]]		[[Category: Twomey, E C]]

OCA at 06:08, 22 August 2018

OCA — Wed, 22 Aug 2018 06:08:31 GMT

←Older revision		Revision as of 06:08, 22 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6dlz is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Open state GluA2 in complex with STZ after micelle signal subtraction==
-		+	<StructureSection load='6dlz' size='340' side='right' caption='[[6dlz]], [[Resolution\|resolution]] 3.90Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6dlz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLZ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYZ:CYCLOTHIAZIDE'>CYZ</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlz OCA], [http://pdbe.org/6dlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlz RCSB], [http://www.ebi.ac.uk/pdbsum/6dlz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlz ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Sobolevsky, A I]]
		+	[[Category: Twomey, E C]]
		+	[[Category: Vassilevski, A A]]
		+	[[Category: Yelshanskaya, M V]]
		+	[[Category: Ion channel]]
		+	[[Category: Transport protein]]

OCA at 05:37, 4 July 2018

OCA — Wed, 04 Jul 2018 05:37:17 GMT

←Older revision		Revision as of 05:37, 4 July 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dlz is ON HOLD	+	The entry 6dlz is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6dlz" [edit=sysop:move=sysop]

OCA — Thu, 14 Jun 2018 05:41:37 GMT

Protected "6dlz" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:41, 14 June 2018

OCA: New page: '''Unreleased structure''' The entry 6dlz is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 14 Jun 2018 05:41:35 GMT

New page: '''Unreleased structure''' The entry 6dlz is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6dlz is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]