6dqn - Revision history

OCA at 00:09, 11 April 2020

OCA — Sat, 11 Apr 2020 00:09:12 GMT

←Older revision		Revision as of 00:09, 11 April 2020
Line 3:		Line 3:
	<SX load='6dqn' size='340' side='right' viewer='molstar' caption='[[6dqn]], [[Resolution\|resolution]] 3.33Å' scene=''>		<SX load='6dqn' size='340' side='right' viewer='molstar' caption='[[6dqn]], [[Resolution\|resolution]] 3.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dqn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DQN OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DQN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dqn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DQN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DQN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITPR3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITPR3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dqn OCA], [http://pdbe.org/6dqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dqn RCSB], [http://www.ebi.ac.uk/pdbsum/6dqn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dqn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6dqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dqn OCA], [http://pdbe.org/6dqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dqn RCSB], [http://www.ebi.ac.uk/pdbsum/6dqn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dqn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 20:56, 6 March 2020

OCA — Fri, 06 Mar 2020 20:56:23 GMT

←Older revision		Revision as of 20:56, 6 March 2020
Line 1:		Line 1:

	==Class 1 IP3-bound human type 3 1,4,5-inositol trisphosphate receptor==		==Class 1 IP3-bound human type 3 1,4,5-inositol trisphosphate receptor==
-	<~~StructureSection~~ load='6dqn' size='340' side='right'caption='[[6dqn]], [[Resolution\|resolution]] 3.33Å' scene=''>	+	<SX load='6dqn' size='340' side='right' viewer='molstar' caption='[[6dqn]], [[Resolution\|resolution]] 3.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6dqn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DQN FirstGlance]. <br>		<table><tr><td colspan='2'>[[6dqn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DQN FirstGlance]. <br>
Line 22:		Line 22:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 17:20, 20 November 2019

OCA — Wed, 20 Nov 2019 17:20:43 GMT

←Older revision		Revision as of 17:20, 20 November 2019
Line 1:		Line 1:
-	~~{{Large structure}}~~	+
	==Class 1 IP3-bound human type 3 1,4,5-inositol trisphosphate receptor==		==Class 1 IP3-bound human type 3 1,4,5-inositol trisphosphate receptor==
-	<StructureSection load='6dqn' size='340' side='right' caption='[[6dqn]], [[Resolution\|resolution]] 3.33Å' scene=''>	+	<StructureSection load='6dqn' size='340' side='right'caption='[[6dqn]], [[Resolution\|resolution]] 3.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6dqn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DQN FirstGlance]. <br>		<table><tr><td colspan='2'>[[6dqn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DQN FirstGlance]. <br>
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dqn OCA], [http://pdbe.org/6dqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dqn RCSB], [http://www.ebi.ac.uk/pdbsum/6dqn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dqn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dqn OCA], [http://pdbe.org/6dqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dqn RCSB], [http://www.ebi.ac.uk/pdbsum/6dqn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dqn ProSAT]</span></td></tr>
	</table>		</table>
-	{{Large structure}}
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ITPR3_HUMAN ITPR3_HUMAN]] Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.		[[http://www.uniprot.org/uniprot/ITPR3_HUMAN ITPR3_HUMAN]] Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
Line 25:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hite, R K]]		[[Category: Hite, R K]]
	[[Category: Paknejad, N]]		[[Category: Paknejad, N]]

OCA at 16:40, 15 August 2018

OCA — Wed, 15 Aug 2018 16:40:36 GMT

←Older revision		Revision as of 16:40, 15 August 2018
Line 3:		Line 3:
	<StructureSection load='6dqn' size='340' side='right' caption='[[6dqn]], [[Resolution\|resolution]] 3.33Å' scene=''>		<StructureSection load='6dqn' size='340' side='right' caption='[[6dqn]], [[Resolution\|resolution]] 3.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dqn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DQN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dqn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DQN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITPR3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dqn OCA], [http://pdbe.org/6dqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dqn RCSB], [http://www.ebi.ac.uk/pdbsum/6dqn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dqn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dqn OCA], [http://pdbe.org/6dqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dqn RCSB], [http://www.ebi.ac.uk/pdbsum/6dqn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dqn ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Hite, R K]]		[[Category: Hite, R K]]
	[[Category: Paknejad, N]]		[[Category: Paknejad, N]]

OCA at 18:51, 1 August 2018

OCA — Wed, 01 Aug 2018 18:51:27 GMT

←Older revision		Revision as of 18:51, 1 August 2018
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	{{Large structure}}
		+	==Class 1 IP3-bound human type 3 1,4,5-inositol trisphosphate receptor==
		+	<StructureSection load='6dqn' size='340' side='right' caption='[[6dqn]], [[Resolution\|resolution]] 3.33Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6dqn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DQN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dqn OCA], [http://pdbe.org/6dqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dqn RCSB], [http://www.ebi.ac.uk/pdbsum/6dqn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dqn ProSAT]</span></td></tr>
		+	</table>
		+	{{Large structure}}
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ITPR3_HUMAN ITPR3_HUMAN]] Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inositol trisphosphate receptors (IP3Rs) are ubiquitous Ca(2+)-permeable channels that mediate release of Ca(2+) from the endoplasmic reticulum, thereby regulating numerous processes including cell division, cell death, differentiation and fertilization. IP3Rs are jointly activated by inositol trisphosphate (IP3) and their permeant ion, Ca(2+). At high concentrations, however, Ca(2+) inhibits activity, ensuring precise spatiotemporal control over intracellular Ca(2+). Despite extensive characterization of IP3R, the mechanisms through which these molecules control channel gating have remained elusive. Here, we present structures of full-length human type 3 IP3Rs in ligand-bound and ligand-free states. Multiple IP3-bound structures demonstrate that the large cytoplasmic domain provides a platform for propagation of long-range conformational changes to the ion-conduction gate. Structures in the presence of Ca(2+) reveal two Ca(2+)-binding sites that induce the disruption of numerous interactions between subunits, thereby inhibiting IP3R. These structures thus provide a mechanistic basis for beginning to understand the regulation of IP3R.

-	~~The entry 6dqn is ON HOLD until Paper Publication~~	+	Structural basis for the regulation of inositol trisphosphate receptors by Ca(2+) and IP3.,Paknejad N, Hite RK Nat Struct Mol Biol. 2018 Jul 16. pii: 10.1038/s41594-018-0089-6. doi:, 10.1038/s41594-018-0089-6. PMID:30013099<ref>PMID:30013099</ref>

-	~~Authors: Hite~~, R.K.~~, Paknejad, N~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Class 1 IP3~~-~~bound human type 3 1,4,5~~-~~inositol trisphosphate receptor~~	+	<div class="pdbe-citations 6dqn" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hite, R K]]
	[[Category: Paknejad, N]]		[[Category: Paknejad, N]]
-	[[Category: ~~Hite, R.K~~]]	+	[[Category: Calcium channel]]
		+	[[Category: Ion channel]]
		+	[[Category: Metal transport]]

OCA: Protected "6dqn" [edit=sysop:move=sysop]

OCA — Wed, 20 Jun 2018 04:08:59 GMT

Protected "6dqn" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:08, 20 June 2018

OCA: New page: '''Unreleased structure''' The entry 6dqn is ON HOLD until Paper Publication Authors: Hite, R.K., Paknejad, N. Description: Class 1 IP3-bound human type 3 1,4,5-inositol trisphosphate ...

OCA — Wed, 20 Jun 2018 04:08:57 GMT

New page: '''Unreleased structure''' The entry 6dqn is ON HOLD until Paper Publication Authors: Hite, R.K., Paknejad, N. Description: Class 1 IP3-bound human type 3 1,4,5-inositol trisphosphate ...

New page

'''Unreleased structure'''

The entry 6dqn is ON HOLD until Paper Publication

Authors: Hite, R.K., Paknejad, N.

Description: Class 1 IP3-bound human type 3 1,4,5-inositol trisphosphate receptor
[[Category: Unreleased Structures]]
[[Category: Paknejad, N]]
[[Category: Hite, R.K]]