6dr9 - Revision history

OCA at 06:13, 11 October 2023

OCA — Wed, 11 Oct 2023 06:13:01 GMT

←Older revision		Revision as of 06:13, 11 October 2023
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	<StructureSection load='6dr9' size='340' side='right'caption='[[6dr9]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='6dr9' size='340' side='right'caption='[[6dr9]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dr9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus~~ pestis~~" (lehmann and neumann 1896) migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DR9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DR9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DR9 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~yopH~~, ~~YPCD1.67c (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.945Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dr9 OCA], [~~http~~://pdbe.org/6dr9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6dr9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6dr9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6dr9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dr9 OCA], [https://pdbe.org/6dr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dr9 RCSB], [https://www.ebi.ac.uk/pdbsum/6dr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dr9 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O68720_YERPE O68720_YERPE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hengge, A C~~]]	+	[[Category: Yersinia pestis]]
-	[[Category: ~~Johnson, S J~~]]	+	[[Category: Hengge AC]]
-	[[Category: ~~Morales, Y~~]]	+	[[Category: Johnson SJ]]
-	[[Category: ~~Hydrolase]]~~	+	[[Category: Morales Y]]
-	~~[[Category: Phosphatase]]~~	+
-	~~[[Category: Ptp]]~~	+
-	~~[[Category: Ptpase]]~~	+
-	~~[[Category: Yoph~~]]	+

OCA at 08:34, 27 November 2019

OCA — Wed, 27 Nov 2019 08:34:07 GMT

←Older revision		Revision as of 08:34, 27 November 2019
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	==Crystal Structure of the YopH PTP1B Chimera 3 PTPase apo form==		==Crystal Structure of the YopH PTP1B Chimera 3 PTPase apo form==
-	<StructureSection load='6dr9' size='340' side='right' caption='[[6dr9]], [[Resolution\|resolution]] 1.94Å' scene=''>	+	<StructureSection load='6dr9' size='340' side='right'caption='[[6dr9]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6dr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DR9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6dr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DR9 FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Hengge, A C]]		[[Category: Hengge, A C]]
	[[Category: Johnson, S J]]		[[Category: Johnson, S J]]

OCA at 10:29, 5 September 2018

OCA — Wed, 05 Sep 2018 10:29:36 GMT

←Older revision		Revision as of 10:29, 5 September 2018
Line 3:		Line 3:
	<StructureSection load='6dr9' size='340' side='right' caption='[[6dr9]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='6dr9' size='340' side='right' caption='[[6dr9]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dr9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DR9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DR9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dr9 OCA], [http://pdbe.org/6dr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dr9 RCSB], [http://www.ebi.ac.uk/pdbsum/6dr9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dr9 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yopH, YPCD1.67c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dr9 OCA], [http://pdbe.org/6dr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dr9 RCSB], [http://www.ebi.ac.uk/pdbsum/6dr9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dr9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:28, 29 August 2018

OCA — Wed, 29 Aug 2018 07:28:07 GMT

←Older revision		Revision as of 07:28, 29 August 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6dr9 is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure of the YopH PTP1B Chimera 3 PTPase apo form==
		+	<StructureSection load='6dr9' size='340' side='right' caption='[[6dr9]], [[Resolution\|resolution]] 1.94Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6dr9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DR9 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dr9 OCA], [http://pdbe.org/6dr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dr9 RCSB], [http://www.ebi.ac.uk/pdbsum/6dr9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dr9 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	To study factors that affect WPD-loop motion in protein tyrosine phosphatases (PTPs), a chimera of PTP1B and YopH was created by transposing the WPD loop from PTP1B to YopH. Several subsequent mutations proved to be necessary to obtain a soluble, active enzyme. That chimera, termed chimera 3, retains productive WPD-loop motions and general acid catalysis with a pH dependency similar to that of the native enzymes. Kinetic isotope effects show the mechanism and transition state for phosphoryl transfer are unaltered. Catalysis of the chimera is slower than that of either of its parent enzymes, although its rate is comparable to those of most native PTPs. X-ray crystallography and nuclear magnetic resonance were used to probe the structure and dynamics of chimera 3. The chimera's structure was found to sample an unproductive hyper-open conformation of its WPD loop, a geometry that has not been observed in either of the parents or in other native PTPs. The reduced catalytic rate is attributed to the protein's sampling of this conformation in solution, reducing the fraction in the catalytically productive loop-closed conformation.

-	~~Authors: Morales~~, Y., Johnson, S.J.~~, Hengge, A~~.C.	+	A YopH PTP1B Chimera Shows the Importance of the WPD-Loop Sequence to the Activity, Structure, and Dynamics of Protein Tyrosine Phosphatases.,Moise G, Morales Y, Beaumont V, Caradonna T, Loria JP, Johnson SJ, Hengge AC Biochemistry. 2018 Aug 28. doi: 10.1021/acs.biochem.8b00663. PMID:30110154<ref>PMID:30110154</ref>

-	~~Description: Crystal Structure~~ of the ~~YopH PTP1B Chimera 3 PTPase apo form~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6dr9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hengge, A C]]
		+	[[Category: Johnson, S J]]
	[[Category: Morales, Y]]		[[Category: Morales, Y]]
-	[[Category: ~~Hengge, A.C~~]]	+	[[Category: Hydrolase]]
-	[[Category: ~~Johnson, S.J~~]]	+	[[Category: Phosphatase]]
		+	[[Category: Ptp]]
		+	[[Category: Ptpase]]
		+	[[Category: Yoph]]

OCA at 04:01, 27 June 2018

OCA — Wed, 27 Jun 2018 04:01:07 GMT

←Older revision		Revision as of 04:01, 27 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dr9 is ON HOLD	+	The entry 6dr9 is ON HOLD until Paper Publication

	Authors: Morales, Y., Johnson, S.J., Hengge, A.C.		Authors: Morales, Y., Johnson, S.J., Hengge, A.C.

OCA: Protected "6dr9" [edit=sysop:move=sysop]

OCA — Wed, 20 Jun 2018 04:11:33 GMT

Protected "6dr9" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:11, 20 June 2018

OCA: New page: '''Unreleased structure''' The entry 6dr9 is ON HOLD Authors: Morales, Y., Johnson, S.J., Hengge, A.C. Description: Crystal Structure of the YopH PTP1B Chimera 3 PTPase apo form [[Cate...

OCA — Wed, 20 Jun 2018 04:11:32 GMT

New page: '''Unreleased structure''' The entry 6dr9 is ON HOLD Authors: Morales, Y., Johnson, S.J., Hengge, A.C. Description: Crystal Structure of the YopH PTP1B Chimera 3 PTPase apo form [[Cate...

New page

'''Unreleased structure'''

The entry 6dr9 is ON HOLD

Authors: Morales, Y., Johnson, S.J., Hengge, A.C.

Description: Crystal Structure of the YopH PTP1B Chimera 3 PTPase apo form
[[Category: Unreleased Structures]]
[[Category: Morales, Y]]
[[Category: Hengge, A.C]]
[[Category: Johnson, S.J]]