6drj - Revision history

OCA at 00:10, 11 April 2020

OCA — Sat, 11 Apr 2020 00:10:43 GMT

←Older revision		Revision as of 00:10, 11 April 2020
Line 3:		Line 3:
	<SX load='6drj' size='340' side='right' viewer='molstar' caption='[[6drj]], [[Resolution\|resolution]] 3.30Å' scene=''>		<SX load='6drj' size='340' side='right' viewer='molstar' caption='[[6drj]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6drj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DRJ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DRJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6drj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DRJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DRJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trpm2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trpm2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6drj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6drj OCA], [http://pdbe.org/6drj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6drj RCSB], [http://www.ebi.ac.uk/pdbsum/6drj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6drj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6drj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6drj OCA], [http://pdbe.org/6drj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6drj RCSB], [http://www.ebi.ac.uk/pdbsum/6drj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6drj ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:57, 6 March 2020

OCA — Fri, 06 Mar 2020 20:57:01 GMT

←Older revision		Revision as of 20:57, 6 March 2020
Line 1:		Line 1:

	==Structure of TRPM2 ion channel receptor by single particle electron cryo-microscopy, ADPR/Ca2+ bound state==		==Structure of TRPM2 ion channel receptor by single particle electron cryo-microscopy, ADPR/Ca2+ bound state==
-	<~~StructureSection~~ load='6drj' size='340' side='right' caption='[[6drj]], [[Resolution\|resolution]] 3.30Å' scene=''>	+	<SX load='6drj' size='340' side='right' viewer='molstar' caption='[[6drj]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6drj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DRJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DRJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[6drj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DRJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DRJ FirstGlance]. <br>
Line 20:		Line 20:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Brachidanio rerio]]		[[Category: Brachidanio rerio]]
		+	[[Category: Large Structures]]
	[[Category: Du, J]]		[[Category: Du, J]]
	[[Category: Huang, Y]]		[[Category: Huang, Y]]

OCA at 08:33, 10 October 2018

OCA — Wed, 10 Oct 2018 08:33:42 GMT

←Older revision		Revision as of 08:33, 10 October 2018
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6drj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6drj OCA], [http://pdbe.org/6drj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6drj RCSB], [http://www.ebi.ac.uk/pdbsum/6drj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6drj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6drj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6drj OCA], [http://pdbe.org/6drj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6drj RCSB], [http://www.ebi.ac.uk/pdbsum/6drj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6drj ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Transient receptor potential melastatin 2 (TRPM2) is a calcium-permeable, non-selective cation channel that has an essential role in diverse physiological processes such as core body temperature regulation, immune response and apoptosis(1-4). TRPM2 is polymodal and can be activated by a wide range of stimuli(1-7), including temperature, oxidative stress and NAD(+)-related metabolites such as ADP-ribose (ADPR). Its activation results in both Ca(2+) entry across the plasma membrane and Ca(2+) release from lysosomes(8), and has been linked to diseases such as ischaemia-reperfusion injury, bipolar disorder and Alzheimer's disease(9-11). Here we report the cryo-electron microscopy structures of the zebrafish TRPM2 in the apo resting (closed) state and in the ADPR/Ca(2+)-bound active (open) state, in which the characteristic NUDT9-H domains hang underneath the MHR1/2 domain. We identify an ADPR-binding site located in the bi-lobed structure of the MHR1/2 domain. Our results provide an insight into the mechanism of activation of the TRPM channel family and define a framework for the development of therapeutic agents to treat neurodegenerative diseases and temperature-related pathological conditions.
		+
		+	Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium.,Huang Y, Winkler PA, Sun W, Lu W, Du J Nature. 2018 Oct;562(7725):145-149. doi: 10.1038/s41586-018-0558-4. Epub 2018 Sep, 24. PMID:30250252<ref>PMID:30250252</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6drj" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:40, 26 September 2018

OCA — Wed, 26 Sep 2018 08:40:14 GMT

←Older revision		Revision as of 08:40, 26 September 2018
Line 1:		Line 1:

-	==~~Ion~~ channel receptor==	+	==Structure of TRPM2 ion channel receptor by single particle electron cryo-microscopy, ADPR/Ca2+ bound state==
	<StructureSection load='6drj' size='340' side='right' caption='[[6drj]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='6drj' size='340' side='right' caption='[[6drj]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6drj]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DRJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DRJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6drj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DRJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DRJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">trpm2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6drj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6drj OCA], [http://pdbe.org/6drj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6drj RCSB], [http://www.ebi.ac.uk/pdbsum/6drj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6drj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6drj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6drj OCA], [http://pdbe.org/6drj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6drj RCSB], [http://www.ebi.ac.uk/pdbsum/6drj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6drj ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Brachidanio rerio]]
	[[Category: Du, J]]		[[Category: Du, J]]
	[[Category: Huang, Y]]		[[Category: Huang, Y]]

OCA at 19:50, 19 September 2018

OCA — Wed, 19 Sep 2018 19:50:34 GMT

←Older revision		Revision as of 19:50, 19 September 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6drj is ~~ON HOLD until Paper Publication~~	+	==Ion channel receptor==
-		+	<StructureSection load='6drj' size='340' side='right' caption='[[6drj]], [[Resolution\|resolution]] 3.30Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6drj]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DRJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DRJ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6drj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6drj OCA], [http://pdbe.org/6drj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6drj RCSB], [http://www.ebi.ac.uk/pdbsum/6drj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6drj ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Du, J]]
		+	[[Category: Huang, Y]]
		+	[[Category: Lu, W]]
		+	[[Category: Sun, W]]
		+	[[Category: Winkler, P]]
		+	[[Category: Transport protein]]

OCA at 05:21, 18 July 2018

OCA — Wed, 18 Jul 2018 05:21:33 GMT

←Older revision		Revision as of 05:21, 18 July 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6drj is ON HOLD	+	The entry 6drj is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6drj" [edit=sysop:move=sysop]

OCA — Wed, 20 Jun 2018 04:13:09 GMT

Protected "6drj" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:13, 20 June 2018

OCA: New page: '''Unreleased structure''' The entry 6drj is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 Jun 2018 04:13:07 GMT

New page: '''Unreleased structure''' The entry 6drj is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6drj is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]