6dso - Revision history

OCA at 14:36, 13 March 2024

OCA — Wed, 13 Mar 2024 14:36:30 GMT

←Older revision		Revision as of 14:36, 13 March 2024
Line 3:		Line 3:
	<SX load='6dso' size='340' side='right' viewer='molstar' caption='[[6dso]], [[Resolution\|resolution]] 3.00Å' scene=''>		<SX load='6dso' size='340' side='right' viewer='molstar' caption='[[6dso]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dso]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DSO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6DSO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dso]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DSO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6dso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dso OCA], [~~http~~://pdbe.org/6dso PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6dso RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6dso PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6dso ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dso OCA], [https://pdbe.org/6dso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dso RCSB], [https://www.ebi.ac.uk/pdbsum/6dso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dso ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/SAA2_MOUSE SAA2_MOUSE]] Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.	+	[https://www.uniprot.org/uniprot/SAA2_MOUSE SAA2_MOUSE] Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SAA2_MOUSE SAA2_MOUSE]] Major acute phase reactant. Apolipoprotein of the HDL complex.	+	[https://www.uniprot.org/uniprot/SAA2_MOUSE SAA2_MOUSE] Major acute phase reactant. Apolipoprotein of the HDL complex.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Systemic AA amyloidosis is a worldwide occurring protein misfolding disease of humans and animals. It arises from the formation of amyloid fibrils from the acute phase protein serum amyloid A. Here, we report the purification and electron cryo-microscopy analysis of amyloid fibrils from a mouse and a human patient with systemic AA amyloidosis. The obtained resolutions are 3.0 A and 2.7 A for the murine and human fibril, respectively. The two fibrils differ in fundamental properties, such as presence of right-hand or left-hand twisted cross-beta sheets and overall fold of the fibril proteins. Yet, both proteins adopt highly similar beta-arch conformations within the N-terminal ~21 residues. Our data demonstrate the importance of the fibril protein N-terminus for the stability of the analyzed amyloid fibril morphologies and suggest strategies of combating this disease by interfering with specific fibril polymorphs.	+
-		+
-	Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids.,Liberta F, Loerch S, Rennegarbe M, Schierhorn A, Westermark P, Westermark GT, Hazenberg BPC, Grigorieff N, Fandrich M, Schmidt M Nat Commun. 2019 Mar 7;10(1):1104. doi: 10.1038/s41467-019-09033-z. PMID:30846696<ref>PMID:30846696</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 6dso" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</SX>		</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Fandrich, M]]	+	[[Category: Fandrich M]]
-	[[Category: Grigorieff, N]]	+	[[Category: Grigorieff N]]
-	[[Category: Liberta, F]]	+	[[Category: Liberta F]]
-	[[Category: Loerch, S]]	+	[[Category: Loerch S]]
-	[[Category: Schmidt, M]]	+	[[Category: Schmidt M]]
-	~~[[Category: Aa-amyloidosis]]~~	+
-	~~[[Category: Cross-beta]]~~	+
-	~~[[Category: Fibril]]~~	+
-	~~[[Category: Helical]]~~	+
-	~~[[Category: Protein fibril~~]]	+

OCA at 00:11, 11 April 2020

OCA — Sat, 11 Apr 2020 00:11:23 GMT

←Older revision		Revision as of 00:11, 11 April 2020
Line 3:		Line 3:
	<SX load='6dso' size='340' side='right' viewer='molstar' caption='[[6dso]], [[Resolution\|resolution]] 3.00Å' scene=''>		<SX load='6dso' size='340' side='right' viewer='molstar' caption='[[6dso]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dso]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DSO OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DSO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dso]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DSO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DSO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dso OCA], [http://pdbe.org/6dso PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dso RCSB], [http://www.ebi.ac.uk/pdbsum/6dso PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dso ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6dso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dso OCA], [http://pdbe.org/6dso PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dso RCSB], [http://www.ebi.ac.uk/pdbsum/6dso PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dso ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 20:57, 6 March 2020

OCA — Fri, 06 Mar 2020 20:57:20 GMT

←Older revision		Revision as of 20:57, 6 March 2020
Line 1:		Line 1:

	==Cryo-EM structure of murine AA amyloid fibril==		==Cryo-EM structure of murine AA amyloid fibril==
-	<~~StructureSection~~ load='6dso' size='340' side='right'caption='[[6dso]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<SX load='6dso' size='340' side='right' viewer='molstar' caption='[[6dso]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6dso]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DSO FirstGlance]. <br>		<table><tr><td colspan='2'>[[6dso]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DSO FirstGlance]. <br>
Line 22:		Line 22:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 08:11, 3 April 2019

OCA — Wed, 03 Apr 2019 08:11:22 GMT

←Older revision		Revision as of 08:11, 3 April 2019
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SAA2_MOUSE SAA2_MOUSE]] Major acute phase reactant. Apolipoprotein of the HDL complex.		[[http://www.uniprot.org/uniprot/SAA2_MOUSE SAA2_MOUSE]] Major acute phase reactant. Apolipoprotein of the HDL complex.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Systemic AA amyloidosis is a worldwide occurring protein misfolding disease of humans and animals. It arises from the formation of amyloid fibrils from the acute phase protein serum amyloid A. Here, we report the purification and electron cryo-microscopy analysis of amyloid fibrils from a mouse and a human patient with systemic AA amyloidosis. The obtained resolutions are 3.0 A and 2.7 A for the murine and human fibril, respectively. The two fibrils differ in fundamental properties, such as presence of right-hand or left-hand twisted cross-beta sheets and overall fold of the fibril proteins. Yet, both proteins adopt highly similar beta-arch conformations within the N-terminal ~21 residues. Our data demonstrate the importance of the fibril protein N-terminus for the stability of the analyzed amyloid fibril morphologies and suggest strategies of combating this disease by interfering with specific fibril polymorphs.
		+
		+	Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids.,Liberta F, Loerch S, Rennegarbe M, Schierhorn A, Westermark P, Westermark GT, Hazenberg BPC, Grigorieff N, Fandrich M, Schmidt M Nat Commun. 2019 Mar 7;10(1):1104. doi: 10.1038/s41467-019-09033-z. PMID:30846696<ref>PMID:30846696</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6dso" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:55, 13 March 2019

OCA — Wed, 13 Mar 2019 11:55:56 GMT

←Older revision		Revision as of 11:55, 13 March 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6dso is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of murine AA amyloid fibril==
-		+	<StructureSection load='6dso' size='340' side='right'caption='[[6dso]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6dso]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DSO FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dso OCA], [http://pdbe.org/6dso PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dso RCSB], [http://www.ebi.ac.uk/pdbsum/6dso PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dso ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/SAA2_MOUSE SAA2_MOUSE]] Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SAA2_MOUSE SAA2_MOUSE]] Major acute phase reactant. Apolipoprotein of the HDL complex.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Fandrich, M]]
		+	[[Category: Grigorieff, N]]
		+	[[Category: Liberta, F]]
		+	[[Category: Loerch, S]]
		+	[[Category: Schmidt, M]]
		+	[[Category: Aa-amyloidosis]]
		+	[[Category: Cross-beta]]
		+	[[Category: Fibril]]
		+	[[Category: Helical]]
		+	[[Category: Protein fibril]]

OCA at 16:59, 1 August 2018

OCA — Wed, 01 Aug 2018 16:59:29 GMT

←Older revision		Revision as of 16:59, 1 August 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dso is ON HOLD	+	The entry 6dso is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6dso" [edit=sysop:move=sysop]

OCA — Wed, 20 Jun 2018 04:16:23 GMT

Protected "6dso" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:16, 20 June 2018

OCA: New page: '''Unreleased structure''' The entry 6dso is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 Jun 2018 04:16:22 GMT

New page: '''Unreleased structure''' The entry 6dso is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6dso is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]