6dt0 - Revision history

OCA at 14:36, 13 March 2024

OCA — Wed, 13 Mar 2024 14:36:35 GMT

←Older revision		Revision as of 14:36, 13 March 2024
Line 3:		Line 3:
	<SX load='6dt0' size='340' side='right' viewer='molstar' caption='[[6dt0]], [[Resolution\|resolution]] 3.70Å' scene=''>		<SX load='6dt0' size='340' side='right' viewer='molstar' caption='[[6dt0]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dt0]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Chrysonilia_crassa Chrysonilia~~ crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DT0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6DT0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dt0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DT0 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.7Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~NCU08166 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=5141 Chrysonilia crassa])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6dt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dt0 OCA], [~~http~~://pdbe.org/6dt0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6dt0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6dt0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6dt0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dt0 OCA], [https://pdbe.org/6dt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dt0 RCSB], [https://www.ebi.ac.uk/pdbsum/6dt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dt0 ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/Q7S4I4_NEUCR Q7S4I4_NEUCR]
-	Calcium transport plays an important role in regulating mitochondrial physiology and pathophysiology. The mitochondrial calcium uniporter (MCU) is a calcium-selective ion channel that is the primary mediator for calcium uptake into the mitochondrial matrix. Here we present the cryo-electron microscopy structure of the full-length MCU from Neurospora crassa to an overall resolution of ~3.7 A. Our structure reveals a tetrameric architecture, with the soluble and transmembrane domains adopting different symmetric arrangements within the channel. The conserved W-D-Phi-Phi-E-P-V-T-Y sequence motif of MCU pore forms a selectivity filter comprising two acidic rings separated by one helical turn along the central axis of the channel pore. ~~The structure combined with mutagenesis gives insight into the basis of calcium recognition~~.	+

-	Cryo-EM structure of a mitochondrial calcium uniporter.,Yoo J, Wu M, Yin Y, Herzik MA Jr, Lander GC, Lee SY Science. 2018 Jun 28. pii: science.aar4056. doi: 10.1126/science.aar4056. PMID:29954988<ref>PMID:29954988</ref>	+	==See Also==
-		+	*[[Mitochondrial calcium uniporter\|Mitochondrial calcium uniporter]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class~~=~~"pdbe-citations 6dt0" style~~=~~"background-color:#fffaf0;"></div>~~	+
-	~~== References~~ ==	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: Chrysonilia crassa]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Herzik~~, M A.J~~]]	+	[[Category: Neurospora crassa]]
-	[[Category: Lander~~, G C~~]]	+	[[Category: Herzik MAJ]]
-	[[Category: Lee, S Y]]	+	[[Category: Lander GC]]
-	[[Category: Wu, M]]	+	[[Category: Lee S-Y]]
-	[[Category: Yin, Y]]	+	[[Category: Wu M]]
-	[[Category: Yoo, J]]	+	[[Category: Yin Y]]
-	~~[[Category: Calcium uptake]]~~	+	[[Category: Yoo J]]
-	~~[[Category: Calcium-selective ion channel]]~~	+
-	~~[[Category: Mitochondrial calcium uniporter]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Uniporter~~]]	+

OCA at 00:11, 11 April 2020

OCA — Sat, 11 Apr 2020 00:11:34 GMT

←Older revision		Revision as of 00:11, 11 April 2020
Line 3:		Line 3:
	<SX load='6dt0' size='340' side='right' viewer='molstar' caption='[[6dt0]], [[Resolution\|resolution]] 3.70Å' scene=''>		<SX load='6dt0' size='340' side='right' viewer='molstar' caption='[[6dt0]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dt0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chrysonilia_crassa Chrysonilia crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DT0 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DT0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dt0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chrysonilia_crassa Chrysonilia crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DT0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DT0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCU08166 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Chrysonilia crassa])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCU08166 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Chrysonilia crassa])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dt0 OCA], [http://pdbe.org/6dt0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dt0 RCSB], [http://www.ebi.ac.uk/pdbsum/6dt0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dt0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6dt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dt0 OCA], [http://pdbe.org/6dt0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dt0 RCSB], [http://www.ebi.ac.uk/pdbsum/6dt0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dt0 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:57, 6 March 2020

OCA — Fri, 06 Mar 2020 20:57:25 GMT

←Older revision		Revision as of 20:57, 6 March 2020
Line 1:		Line 1:

	==Cryo-EM structure of a mitochondrial calcium uniporter==		==Cryo-EM structure of a mitochondrial calcium uniporter==
-	<~~StructureSection~~ load='6dt0' size='340' side='right' caption='[[6dt0]], [[Resolution\|resolution]] 3.70Å' scene=''>	+	<SX load='6dt0' size='340' side='right' viewer='molstar' caption='[[6dt0]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6dt0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chrysonilia_crassa Chrysonilia crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DT0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6dt0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chrysonilia_crassa Chrysonilia crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DT0 FirstGlance]. <br>
Line 20:		Line 20:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Chrysonilia crassa]]		[[Category: Chrysonilia crassa]]
		+	[[Category: Large Structures]]
	[[Category: Herzik, M A.J]]		[[Category: Herzik, M A.J]]
	[[Category: Lander, G C]]		[[Category: Lander, G C]]

OCA at 16:41, 15 August 2018

OCA — Wed, 15 Aug 2018 16:41:23 GMT

←Older revision		Revision as of 16:41, 15 August 2018
Line 3:		Line 3:
	<StructureSection load='6dt0' size='340' side='right' caption='[[6dt0]], [[Resolution\|resolution]] 3.70Å' scene=''>		<StructureSection load='6dt0' size='340' side='right' caption='[[6dt0]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dt0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DT0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dt0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chrysonilia_crassa Chrysonilia crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DT0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCU08166 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Chrysonilia crassa])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dt0 OCA], [http://pdbe.org/6dt0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dt0 RCSB], [http://www.ebi.ac.uk/pdbsum/6dt0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dt0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dt0 OCA], [http://pdbe.org/6dt0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dt0 RCSB], [http://www.ebi.ac.uk/pdbsum/6dt0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dt0 ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Chrysonilia crassa]]
	[[Category: Herzik, M A.J]]		[[Category: Herzik, M A.J]]
	[[Category: Lander, G C]]		[[Category: Lander, G C]]

OCA at 05:44, 11 July 2018

OCA — Wed, 11 Jul 2018 05:44:57 GMT

←Older revision		Revision as of 05:44, 11 July 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6dt0 is ~~ON HOLD until Paper~~ Publication	+	==Cryo-EM structure of a mitochondrial calcium uniporter==
		+	<StructureSection load='6dt0' size='340' side='right' caption='[[6dt0]], [[Resolution\|resolution]] 3.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6dt0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DT0 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dt0 OCA], [http://pdbe.org/6dt0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dt0 RCSB], [http://www.ebi.ac.uk/pdbsum/6dt0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dt0 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Calcium transport plays an important role in regulating mitochondrial physiology and pathophysiology. The mitochondrial calcium uniporter (MCU) is a calcium-selective ion channel that is the primary mediator for calcium uptake into the mitochondrial matrix. Here we present the cryo-electron microscopy structure of the full-length MCU from Neurospora crassa to an overall resolution of ~3.7 A. Our structure reveals a tetrameric architecture, with the soluble and transmembrane domains adopting different symmetric arrangements within the channel. The conserved W-D-Phi-Phi-E-P-V-T-Y sequence motif of MCU pore forms a selectivity filter comprising two acidic rings separated by one helical turn along the central axis of the channel pore. The structure combined with mutagenesis gives insight into the basis of calcium recognition.

-	~~Authors~~:	+	Cryo-EM structure of a mitochondrial calcium uniporter.,Yoo J, Wu M, Yin Y, Herzik MA Jr, Lander GC, Lee SY Science. 2018 Jun 28. pii: science.aar4056. doi: 10.1126/science.aar4056. PMID:29954988<ref>PMID:29954988</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6dt0" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Herzik, M A.J]]
		+	[[Category: Lander, G C]]
		+	[[Category: Lee, S Y]]
		+	[[Category: Wu, M]]
		+	[[Category: Yin, Y]]
		+	[[Category: Yoo, J]]
		+	[[Category: Calcium uptake]]
		+	[[Category: Calcium-selective ion channel]]
		+	[[Category: Mitochondrial calcium uniporter]]
		+	[[Category: Transport protein]]
		+	[[Category: Uniporter]]

OCA at 05:41, 4 July 2018

OCA — Wed, 04 Jul 2018 05:41:22 GMT

←Older revision		Revision as of 05:41, 4 July 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dt0 is ON HOLD	+	The entry 6dt0 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6dt0" [edit=sysop:move=sysop]

OCA — Wed, 20 Jun 2018 04:17:17 GMT

Protected "6dt0" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:17, 20 June 2018

OCA: New page: '''Unreleased structure''' The entry 6dt0 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 Jun 2018 04:17:15 GMT

New page: '''Unreleased structure''' The entry 6dt0 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6dt0 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]