6dtq - Revision history

OCA at 06:13, 11 October 2023

OCA — Wed, 11 Oct 2023 06:13:54 GMT

←Older revision		Revision as of 06:13, 11 October 2023
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	<StructureSection load='6dtq' size='340' side='right'caption='[[6dtq]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='6dtq' size='340' side='right'caption='[[6dtq]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dtq]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Thema Thema~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DTQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DTQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dtq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DTQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DTQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MAL~~:~~MALTOSE~~'>~~MAL~~</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dtq OCA], [~~http~~://pdbe.org/6dtq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6dtq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6dtq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6dtq ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dtq OCA], [https://pdbe.org/6dtq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dtq RCSB], [https://www.ebi.ac.uk/pdbsum/6dtq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dtq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G4XU73_THEMA G4XU73_THEMA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6dtq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6dtq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Maltose-binding protein 3D structures\|Maltose-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Thema~~]]	+	[[Category: Thermotoga maritima MSB8]]
-	[[Category: Cuneo~~, M J~~]]	+	[[Category: Cuneo MJ]]
-	[[Category: Shukla, S]]	+	[[Category: Shukla S]]
-	~~[[Category: Maltose binding protein]]~~	+
-	~~[[Category: Maltotetraose]]~~	+
-	~~[[Category: Periplasmic binding protein]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 08:11, 3 April 2019

OCA — Wed, 03 Apr 2019 08:11:32 GMT

←Older revision		Revision as of 08:11, 3 April 2019
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	==Maltose bound T. maritima MalE3==		==Maltose bound T. maritima MalE3==
-	<StructureSection load='6dtq' size='340' side='right' caption='[[6dtq]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='6dtq' size='340' side='right'caption='[[6dtq]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dtq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DTQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DTQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dtq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thema Thema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DTQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DTQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dtq OCA], [http://pdbe.org/6dtq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dtq RCSB], [http://www.ebi.ac.uk/pdbsum/6dtq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dtq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dtq OCA], [http://pdbe.org/6dtq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dtq RCSB], [http://www.ebi.ac.uk/pdbsum/6dtq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dtq ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The genome of the hyperthermophile Thermotoga maritima contains three isoforms of maltose binding protein (MBP) that are high-affinity receptors for di-, tri-, and tetrasaccharides. Two of these proteins (tmMBP1 and tmMBP2) share significant sequence identity, approximately 90%, while the third (tmMBP3) shares less than 40% identity. MBP from Escherichia coli (ecMBP) shares 35% sequence identity with the tmMBPs. This subset of MBP isoforms offers an interesting opportunity to investigate the mechanisms underlying the evolution of substrate specificity and affinity profiles in a genome where redundant MBP genes are present. In this study, the X-ray crystal structures of tmMBP1, tmMBP2, and tmMBP3 are reported in the absence and presence of oligosaccharides. tmMBP1 and tmMBP2 have binding pockets that are larger than that of tmMBP3, enabling them to bind to larger substrates, while tmMBP1 and tmMBP2 also undergo substrate-induced hinge bending motions ( approximately 52 degrees ) that are larger than that of tmMBP3 ( approximately 35 degrees ). Small-angle X-ray scattering was used to compare protein behavior in solution, and computer simulations provided insights into dynamics of these proteins. Comparing quantitative protein-substrate interactions and dynamical properties of tmMBPs with those of the promiscuous ecMBP and disaccharide selective Thermococcus litoralis MBP provides insights into the features that enable selective binding. Collectively, the results provide insights into how the structure and dynamics of tmMBP homologues enable them to differentiate between a myriad of chemical entities while maintaining their common fold.
		+
		+	Differential Substrate Recognition by Maltose Binding Proteins Influenced by Structure and Dynamics.,Shukla S, Bafna K, Gullett C, Myles DAA, Agarwal PK, Cuneo MJ Biochemistry. 2018 Oct 9;57(40):5864-5876. doi: 10.1021/acs.biochem.8b00783. Epub, 2018 Sep 25. PMID:30204415<ref>PMID:30204415</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6dtq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Thema]]
	[[Category: Cuneo, M J]]		[[Category: Cuneo, M J]]
	[[Category: Shukla, S]]		[[Category: Shukla, S]]

OCA at 19:50, 19 September 2018

OCA — Wed, 19 Sep 2018 19:50:43 GMT

←Older revision		Revision as of 19:50, 19 September 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6dtq is ~~ON HOLD until Paper Publication~~	+	==Maltose bound T. maritima MalE3==
-		+	<StructureSection load='6dtq' size='340' side='right' caption='[[6dtq]], [[Resolution\|resolution]] 2.15Å' scene=''>
-	~~Authors~~: ~~Cuneo~~, M.J., ~~Shukla~~, S.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6dtq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DTQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DTQ FirstGlance]. <br>
-	~~Description~~: ~~Maltose bound T~~. ~~maritima MalE3~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dtq OCA], [http://pdbe.org/6dtq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dtq RCSB], [http://www.ebi.ac.uk/pdbsum/6dtq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dtq ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cuneo, M J]]
	[[Category: Shukla, S]]		[[Category: Shukla, S]]
-	[[Category: ~~Cuneo, M.J~~]]	+	[[Category: Maltose binding protein]]
		+	[[Category: Maltotetraose]]
		+	[[Category: Periplasmic binding protein]]
		+	[[Category: Sugar binding protein]]

OCA at 05:41, 4 July 2018

OCA — Wed, 04 Jul 2018 05:41:32 GMT

←Older revision		Revision as of 05:41, 4 July 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dtq is ON HOLD	+	The entry 6dtq is ON HOLD until Paper Publication

	Authors: Cuneo, M.J., Shukla, S.		Authors: Cuneo, M.J., Shukla, S.

OCA: Protected "6dtq" [edit=sysop:move=sysop]

OCA — Wed, 27 Jun 2018 04:04:36 GMT

Protected "6dtq" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:04, 27 June 2018

OCA: New page: '''Unreleased structure''' The entry 6dtq is ON HOLD Authors: Cuneo, M.J., Shukla, S. Description: Maltose bound T. maritima MalE3 Category: Unreleased Structures [[Category: Shukl...

OCA — Wed, 27 Jun 2018 04:04:35 GMT

New page: '''Unreleased structure''' The entry 6dtq is ON HOLD Authors: Cuneo, M.J., Shukla, S. Description: Maltose bound T. maritima MalE3 Category: Unreleased Structures [[Category: Shukl...

New page

'''Unreleased structure'''

The entry 6dtq is ON HOLD

Authors: Cuneo, M.J., Shukla, S.

Description: Maltose bound T. maritima MalE3
[[Category: Unreleased Structures]]
[[Category: Shukla, S]]
[[Category: Cuneo, M.J]]