6due - Revision history

OCA at 06:14, 11 October 2023

OCA — Wed, 11 Oct 2023 06:14:16 GMT

←Older revision		Revision as of 06:14, 11 October 2023
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	<StructureSection load='6due' size='340' side='right'caption='[[6due]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='6due' size='340' side='right'caption='[[6due]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6due]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Toxgg Toxgg~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DUE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DUE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6due]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii_GT1 Toxoplasma gondii GT1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DUE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGGT1_235470 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=507601 TOXGG])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6due FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6due OCA], [~~http~~://pdbe.org/6due PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6due RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6due PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6due ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6due FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6due OCA], [https://pdbe.org/6due PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6due RCSB], [https://www.ebi.ac.uk/pdbsum/6due PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6due ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/S7W634_TOXGG S7W634_TOXGG]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Toxgg~~]]	+	[[Category: Toxoplasma gondii GT1]]
-	[[Category: Boulanger~~, M J~~]]	+	[[Category: Boulanger MJ]]
-	[[Category: Powell~~, C J]]~~	+	[[Category: Powell CJ]]
-	~~[[Category: Apicomplexan]]~~	+
-	~~[[Category: Atpase]]~~	+
-	~~[[Category: Motor protein]]~~	+
-	~~[[Category: Myosin~~]]	+

OCA at 08:54, 8 January 2020

OCA — Wed, 08 Jan 2020 08:54:32 GMT

←Older revision		Revision as of 08:54, 8 January 2020
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	==Toxoplasma gondii MyoA, a Class-XIV myosin, in the pre-powerstroke state==		==Toxoplasma gondii MyoA, a Class-XIV myosin, in the pre-powerstroke state==
-	<StructureSection load='6due' size='340' side='right' caption='[[6due]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='6due' size='340' side='right'caption='[[6due]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6due]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DUE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DUE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6due]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgg Toxgg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DUE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DUE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGGT1_235470 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=507601 TOXGG])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6due FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6due OCA], [http://pdbe.org/6due PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6due RCSB], [http://www.ebi.ac.uk/pdbsum/6due PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6due ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6due FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6due OCA], [http://pdbe.org/6due PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6due RCSB], [http://www.ebi.ac.uk/pdbsum/6due PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6due ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 6due" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6due" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Myosin 3D Structures\|Myosin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Toxgg]]
	[[Category: Boulanger, M J]]		[[Category: Boulanger, M J]]
	[[Category: Powell, C J]]		[[Category: Powell, C J]]

OCA at 06:51, 31 October 2018

OCA — Wed, 31 Oct 2018 06:51:11 GMT

←Older revision		Revision as of 06:51, 31 October 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6due is ~~ON HOLD until Paper~~ Publication	+	==Toxoplasma gondii MyoA, a Class-XIV myosin, in the pre-powerstroke state==
		+	<StructureSection load='6due' size='340' side='right' caption='[[6due]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6due]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DUE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DUE FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6due FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6due OCA], [http://pdbe.org/6due PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6due RCSB], [http://www.ebi.ac.uk/pdbsum/6due PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6due ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Parasites of the phylum Apicomplexa are responsible for significant morbidity and mortality on a global scale. Central to the virulence of these pathogens are the phylum-specific, unconventional class XIV myosins that power the essential processes of parasite motility and host cell invasion. Notably, class XIV myosins differ from human myosins in key functional regions, yet they are capable of fast movement along actin filaments with kinetics rivaling previously studied myosins. Toward establishing a detailed molecular mechanism of class XIV motility, we determined the 2.6-A resolution crystal structure of the Toxoplasma gondii MyoA (TgMyoA) motor domain. Structural analysis reveals intriguing strategies for force transduction and chemomechanical coupling that rely on a divergent SH1/SH2 region, the class-defining "HYAG"-site polymorphism, and the actin-binding surface. In vitro motility assays and hydrogen-deuterium exchange coupled with MS further reveal the mechanistic underpinnings of phosphorylation-dependent modulation of TgMyoA motility whereby localized regions of increased stability and order correlate with enhanced motility. Analysis of solvent-accessible pockets reveals striking differences between apicomplexan class XIV and human myosins. Extending these analyses to high-confidence homology models of Plasmodium and Cryptosporidium MyoA motor domains supports the intriguing potential of designing class-specific, yet broadly active, apicomplexan myosin inhibitors. The successful expression of the functional TgMyoA complex combined with our crystal structure of the motor domain provides a strong foundation in support of detailed structure-function studies and enables the development of small-molecule inhibitors targeting these devastating global pathogens.

-	~~Authors~~:	+	Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA from Toxoplasma gondii.,Powell CJ, Ramaswamy R, Kelsen A, Hamelin DJ, Warshaw DM, Bosch J, Burke JE, Ward GE, Boulanger MJ Proc Natl Acad Sci U S A. 2018 Oct 22. pii: 1811167115. doi:, 10.1073/pnas.1811167115. PMID:30348763<ref>PMID:30348763</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6due" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Boulanger, M J]]
		+	[[Category: Powell, C J]]
		+	[[Category: Apicomplexan]]
		+	[[Category: Atpase]]
		+	[[Category: Motor protein]]
		+	[[Category: Myosin]]

OCA at 04:38, 22 August 2018

OCA — Wed, 22 Aug 2018 04:38:00 GMT

←Older revision		Revision as of 04:38, 22 August 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6due is ON HOLD	+	The entry 6due is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6due" [edit=sysop:move=sysop]

OCA — Wed, 27 Jun 2018 04:07:03 GMT

Protected "6due" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:07, 27 June 2018

OCA: New page: '''Unreleased structure''' The entry 6due is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Jun 2018 04:07:02 GMT

New page: '''Unreleased structure''' The entry 6due is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6due is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]