6dw1 - Revision history

OCA at 10:20, 15 November 2023

OCA — Wed, 15 Nov 2023 10:20:41 GMT

←Older revision		Revision as of 10:20, 15 November 2023
Line 3:		Line 3:
	<SX load='6dw1' size='340' side='right' viewer='molstar' caption='[[6dw1]], [[Resolution\|resolution]] 3.10Å' scene=''>		<SX load='6dw1' size='340' side='right' viewer='molstar' caption='[[6dw1]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dw1]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DW1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6DW1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dw1]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DW1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6dw0\|6dw0]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gabrg2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Gabra1, Gabra-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Gabrb1, Gabrb-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dw1 OCA], [https://pdbe.org/6dw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dw1 RCSB], [https://www.ebi.ac.uk/pdbsum/6dw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dw1 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6dw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dw1 OCA], [~~http~~://pdbe.org/6dw1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6dw1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6dw1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6dw1 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GBRG2_RAT GBRG2_RAT]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [[http://www.uniprot.org/uniprot/GBRB1_RAT GBRB1_RAT]] Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.<ref>PMID:18281286</ref> <ref>PMID:1977069</ref> [[http://www.uniprot.org/uniprot/GBRA1_RAT GBRA1_RAT]] Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.<ref>PMID:1376242</ref> <ref>PMID:18281286</ref> <ref>PMID:2540033</ref>	+	[https://www.uniprot.org/uniprot/GBRG2_RAT GBRG2_RAT] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gouaux, E]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Phulera, S]]	+	[[Category: Gouaux E]]
-	[[Category: Yoshioka, C]]	+	[[Category: Phulera S]]
-	[[Category: Yu, J]]	+	[[Category: Yoshioka C]]
-	[[Category: Zhu, H]]	+	[[Category: Yu J]]
-	~~[[Category: Cys loop receptor]]~~	+	[[Category: Zhu H]]
-	~~[[Category: Gaba]]~~	+
-	~~[[Category: Gaba receptor]]~~	+
-	~~[[Category: Ion channel]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Neurotransmission~~]]	+

OCA at 00:13, 11 April 2020

OCA — Sat, 11 Apr 2020 00:13:14 GMT

←Older revision		Revision as of 00:13, 11 April 2020
Line 3:		Line 3:
	<SX load='6dw1' size='340' side='right' viewer='molstar' caption='[[6dw1]], [[Resolution\|resolution]] 3.10Å' scene=''>		<SX load='6dw1' size='340' side='right' viewer='molstar' caption='[[6dw1]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dw1]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DW1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DW1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dw1]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DW1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DW1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6dw0\|6dw0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6dw0\|6dw0]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gabrg2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Gabra1, Gabra-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Gabrb1, Gabrb-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gabrg2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Gabra1, Gabra-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Gabrb1, Gabrb-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dw1 OCA], [http://pdbe.org/6dw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dw1 RCSB], [http://www.ebi.ac.uk/pdbsum/6dw1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dw1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6dw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dw1 OCA], [http://pdbe.org/6dw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dw1 RCSB], [http://www.ebi.ac.uk/pdbsum/6dw1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dw1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 20:58, 6 March 2020

OCA — Fri, 06 Mar 2020 20:58:06 GMT

←Older revision		Revision as of 20:58, 6 March 2020
Line 1:		Line 1:

	==Cryo-EM structure of the benzodiazepine-sensitive alpha1beta1gamma2S tri-heteromeric GABAA receptor in complex with GABA (ECD map)==		==Cryo-EM structure of the benzodiazepine-sensitive alpha1beta1gamma2S tri-heteromeric GABAA receptor in complex with GABA (ECD map)==
-	<~~StructureSection~~ load='6dw1' size='340' side='right'caption='[[6dw1]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<SX load='6dw1' size='340' side='right' viewer='molstar' caption='[[6dw1]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6dw1]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DW1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6dw1]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DW1 FirstGlance]. <br>
Line 26:		Line 26:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 17:22, 20 November 2019

OCA — Wed, 20 Nov 2019 17:22:12 GMT

←Older revision		Revision as of 17:22, 20 November 2019
Line 1:		Line 1:

	==Cryo-EM structure of the benzodiazepine-sensitive alpha1beta1gamma2S tri-heteromeric GABAA receptor in complex with GABA (ECD map)==		==Cryo-EM structure of the benzodiazepine-sensitive alpha1beta1gamma2S tri-heteromeric GABAA receptor in complex with GABA (ECD map)==
-	<StructureSection load='6dw1' size='340' side='right' caption='[[6dw1]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='6dw1' size='340' side='right'caption='[[6dw1]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dw1]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DW1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dw1]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DW1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6dw0\|6dw0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6dw0\|6dw0]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gabrg2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Gabra1, Gabra-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Gabrb1, Gabrb-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dw1 OCA], [http://pdbe.org/6dw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dw1 RCSB], [http://www.ebi.ac.uk/pdbsum/6dw1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dw1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dw1 OCA], [http://pdbe.org/6dw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dw1 RCSB], [http://www.ebi.ac.uk/pdbsum/6dw1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dw1 ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 6dw1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6dw1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[GABA receptor 3D structures\|GABA receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Gouaux, E]]		[[Category: Gouaux, E]]
	[[Category: Phulera, S]]		[[Category: Phulera, S]]

OCA at 21:50, 9 August 2018

OCA — Thu, 09 Aug 2018 21:50:06 GMT

←Older revision		Revision as of 21:50, 9 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6dw1 is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Cryo-EM structure of the benzodiazepine-sensitive alpha1beta1gamma2S tri-heteromeric GABAA receptor in complex with GABA (ECD map)==
		+	<StructureSection load='6dw1' size='340' side='right' caption='[[6dw1]], [[Resolution\|resolution]] 3.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6dw1]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DW1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6dw0\|6dw0]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dw1 OCA], [http://pdbe.org/6dw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dw1 RCSB], [http://www.ebi.ac.uk/pdbsum/6dw1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dw1 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GBRG2_RAT GBRG2_RAT]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [[http://www.uniprot.org/uniprot/GBRB1_RAT GBRB1_RAT]] Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.<ref>PMID:18281286</ref> <ref>PMID:1977069</ref> [[http://www.uniprot.org/uniprot/GBRA1_RAT GBRA1_RAT]] Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.<ref>PMID:1376242</ref> <ref>PMID:18281286</ref> <ref>PMID:2540033</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fast inhibitory neurotransmission in mammalian nervous system is largely mediated by GABAA receptors, chloride-selective members of the superfamily of pentameric Cys-loop receptors. Native GABAA receptors are heteromeric assemblies sensitive to many important drugs, from sedatives to anesthetics and anticonvulsant agents, with mutant forms of GABAA receptors implicated in multiple neurological diseases. Despite profound importance of heteromeric GABAA receptors in neuroscience and medicine, they have proven recalcitrant to structure determination. Here we present the structure of tri-heteromeric alpha1beta1gamma2SEM GABAA receptor in complex with GABA, determined by single particle cryo-EM at 3.1-3.8 A resolution, elucidating molecular principles of receptor assembly and agonist binding. Remarkable N-linked glycosylation on the alpha1 subunit occludes the extracellular vestibule of the ion channel and is poised to modulate receptor assembly and perhaps ion channel gating. Our work provides a pathway to structural studies of heteromeric GABAA receptors and a framework for rational design of novel therapeutic agents.

-	~~Authors~~:	+	Cryo-EM structure of the benzodiazepine-sensitive alpha1beta1gamma2S tri-heteromeric GABAA receptor in complex with GABA.,Phulera S, Zhu H, Yu J, Claxton DP, Yoder N, Yoshioka C, Gouaux E Elife. 2018 Jul 25;7. pii: 39383. doi: 10.7554/eLife.39383. PMID:30044221<ref>PMID:30044221</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6dw1" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gouaux, E]]
		+	[[Category: Phulera, S]]
		+	[[Category: Yoshioka, C]]
		+	[[Category: Yu, J]]
		+	[[Category: Zhu, H]]
		+	[[Category: Cys loop receptor]]
		+	[[Category: Gaba]]
		+	[[Category: Gaba receptor]]
		+	[[Category: Ion channel]]
		+	[[Category: Membrane protein]]
		+	[[Category: Neurotransmission]]

OCA at 16:59, 1 August 2018

OCA — Wed, 01 Aug 2018 16:59:49 GMT

←Older revision		Revision as of 16:59, 1 August 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dw1 is ON HOLD	+	The entry 6dw1 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6dw1" [edit=sysop:move=sysop]

OCA — Wed, 04 Jul 2018 05:46:39 GMT

Protected "6dw1" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:46, 4 July 2018

OCA: New page: '''Unreleased structure''' The entry 6dw1 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 04 Jul 2018 05:46:38 GMT

New page: '''Unreleased structure''' The entry 6dw1 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6dw1 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]