6dzm - Revision history

OCA at 00:14, 11 April 2020

OCA — Sat, 11 Apr 2020 00:14:24 GMT

←Older revision		Revision as of 00:14, 11 April 2020
Line 3:		Line 3:
	<SX load='6dzm' size='340' side='right' viewer='molstar' caption='[[6dzm]], [[Resolution\|resolution]] 4.29Å' scene=''>		<SX load='6dzm' size='340' side='right' viewer='molstar' caption='[[6dzm]], [[Resolution\|resolution]] 4.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dzm]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdbv Bdbv] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DZM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dzm]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdbv Bdbv] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DZM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GP, DF49_53413gpGP, DH33_45404gpGP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=565995 BDBV])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GP, DF49_53413gpGP, DH33_45404gpGP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=565995 BDBV])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dzm OCA], [http://pdbe.org/6dzm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dzm RCSB], [http://www.ebi.ac.uk/pdbsum/6dzm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dzm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6dzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dzm OCA], [http://pdbe.org/6dzm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dzm RCSB], [http://www.ebi.ac.uk/pdbsum/6dzm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dzm ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:58, 6 March 2020

OCA — Fri, 06 Mar 2020 20:58:39 GMT

←Older revision		Revision as of 20:58, 6 March 2020
Line 1:		Line 1:

	==Bundibugyo virus GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI-15878 Fab==		==Bundibugyo virus GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI-15878 Fab==
-	<~~StructureSection~~ load='6dzm' size='340' side='right'caption='[[6dzm]], [[Resolution\|resolution]] 4.29Å' scene=''>	+	<SX load='6dzm' size='340' side='right' viewer='molstar' caption='[[6dzm]], [[Resolution\|resolution]] 4.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6dzm]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdbv Bdbv] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DZM FirstGlance]. <br>		<table><tr><td colspan='2'>[[6dzm]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdbv Bdbv] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DZM FirstGlance]. <br>
Line 24:		Line 24:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Bdbv]]		[[Category: Bdbv]]
	[[Category: Human]]		[[Category: Human]]

OCA at 10:17, 18 December 2019

OCA — Wed, 18 Dec 2019 10:17:00 GMT

←Older revision		Revision as of 10:17, 18 December 2019
Line 1:		Line 1:

	==Bundibugyo virus GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI-15878 Fab==		==Bundibugyo virus GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI-15878 Fab==
-	<StructureSection load='6dzm' size='340' side='right' caption='[[6dzm]], [[Resolution\|resolution]] 4.29Å' scene=''>	+	<StructureSection load='6dzm' size='340' side='right'caption='[[6dzm]], [[Resolution\|resolution]] 4.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6dzm]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdbv Bdbv] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DZM FirstGlance]. <br>		<table><tr><td colspan='2'>[[6dzm]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdbv Bdbv] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DZM FirstGlance]. <br>
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 6dzm" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6dzm" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Glycoprotein GP 3D structures\|Glycoprotein GP 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 27:
	[[Category: Bdbv]]		[[Category: Bdbv]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Murin, C D]]		[[Category: Murin, C D]]
	[[Category: Ward, A B]]		[[Category: Ward, A B]]

OCA at 20:21, 19 September 2018

OCA — Wed, 19 Sep 2018 20:21:00 GMT

←Older revision		Revision as of 20:21, 19 September 2018
Line 3:		Line 3:
	<StructureSection load='6dzm' size='340' side='right' caption='[[6dzm]], [[Resolution\|resolution]] 4.29Å' scene=''>		<StructureSection load='6dzm' size='340' side='right' caption='[[6dzm]], [[Resolution\|resolution]] 4.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dzm]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DZM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dzm]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdbv Bdbv] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DZM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GP, DF49_53413gpGP, DH33_45404gpGP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=565995 BDBV])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dzm OCA], [http://pdbe.org/6dzm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dzm RCSB], [http://www.ebi.ac.uk/pdbsum/6dzm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dzm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dzm OCA], [http://pdbe.org/6dzm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dzm RCSB], [http://www.ebi.ac.uk/pdbsum/6dzm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dzm ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Monoclonal antibodies (mAbs) with pan-ebolavirus cross-reactivity are highly desirable, but development of such mAbs is limited by a lack of a molecular understanding of cross-reactive epitopes. The antibody ADI-15878 was previously identified from a human survivor of Ebola virus Makona variant (EBOV/Mak) infection. This mAb demonstrated potent neutralizing activity against all known ebolaviruses and provided protection in rodent and ferret models against three ebolavirus species. Here, we describe the unliganded crystal structure of ADI-15878 as well as the cryo-EM structures of ADI-15878 in complex with the EBOV/Mak and Bundibugyo virus (BDBV) glycoproteins (GPs). ADI-15878 binds through an induced-fit mechanism by targeting highly conserved residues in the internal fusion loop (IFL), bridging across GP protomers via the heptad repeat 1 (HR1) region. Our structures provide a more complete description of the ebolavirus immunogenic landscape, as well as a molecular basis for how rare but potent antibodies target conserved filoviral fusion machinery.
		+
		+	Structural Basis of Pan-Ebolavirus Neutralization by an Antibody Targeting the Glycoprotein Fusion Loop.,Murin CD, Bruhn JF, Bornholdt ZA, Copps J, Stanfield R, Ward AB Cell Rep. 2018 Sep 4;24(10):2723-2732.e4. doi: 10.1016/j.celrep.2018.08.009. PMID:30184505<ref>PMID:30184505</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6dzm" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bdbv]]
		+	[[Category: Human]]
	[[Category: Murin, C D]]		[[Category: Murin, C D]]
	[[Category: Ward, A B]]		[[Category: Ward, A B]]

OCA at 07:37, 12 September 2018

OCA — Wed, 12 Sep 2018 07:37:20 GMT

←Older revision		Revision as of 07:37, 12 September 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6dzm is ON HOLD until Paper Publication~~	+	==Bundibugyo virus GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI-15878 Fab==
-		+	<StructureSection load='6dzm' size='340' side='right' caption='[[6dzm]], [[Resolution\|resolution]] 4.29Å' scene=''>
-	~~Authors: Murin, C.D., Ward, A.B.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6dzm]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DZM FirstGlance]. <br>
-	~~Description:~~ Bundibugyo virus GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI-15878 Fab	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dzm OCA], [http://pdbe.org/6dzm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dzm RCSB], [http://www.ebi.ac.uk/pdbsum/6dzm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dzm ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Ward~~, A.B]]	+	</table>
-	[[Category: Murin, C.D]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Murin, C D]]
		+	[[Category: Ward, A B]]
		+	[[Category: Antibody]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Hr1]]
		+	[[Category: Internal fusion loop]]
		+	[[Category: Pan-ebolavirus]]
		+	[[Category: Viral protein]]

OCA at 05:51, 25 July 2018

OCA — Wed, 25 Jul 2018 05:51:23 GMT

←Older revision		Revision as of 05:51, 25 July 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dzm is ON HOLD	+	The entry 6dzm is ON HOLD until Paper Publication

	Authors: Murin, C.D., Ward, A.B.		Authors: Murin, C.D., Ward, A.B.

OCA: Protected "6dzm" [edit=sysop:move=sysop]

OCA — Wed, 11 Jul 2018 04:11:03 GMT

Protected "6dzm" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:11, 11 July 2018

OCA: New page: '''Unreleased structure''' The entry 6dzm is ON HOLD Authors: Murin, C.D., Ward, A.B. Description: Bundibugyo virus GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI...

OCA — Wed, 11 Jul 2018 04:11:02 GMT

New page: '''Unreleased structure''' The entry 6dzm is ON HOLD Authors: Murin, C.D., Ward, A.B. Description: Bundibugyo virus GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI...

New page

'''Unreleased structure'''

The entry 6dzm is ON HOLD

Authors: Murin, C.D., Ward, A.B.

Description: Bundibugyo virus GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI-15878 Fab
[[Category: Unreleased Structures]]
[[Category: Ward, A.B]]
[[Category: Murin, C.D]]