6dzn - Revision history

OCA at 10:17, 18 December 2019

OCA — Wed, 18 Dec 2019 10:17:18 GMT

←Older revision		Revision as of 10:17, 18 December 2019
Line 1:		Line 1:

	==Pan-ebolavirus human antibody ADI-15878 Fab==		==Pan-ebolavirus human antibody ADI-15878 Fab==
-	<StructureSection load='6dzn' size='340' side='right' caption='[[6dzn]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='6dzn' size='340' side='right'caption='[[6dzn]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6dzn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DZN FirstGlance]. <br>		<table><tr><td colspan='2'>[[6dzn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DZN FirstGlance]. <br>
Line 16:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 6dzn" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6dzn" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bruhn, J F]]		[[Category: Bruhn, J F]]
	[[Category: Murin, C D]]		[[Category: Murin, C D]]

OCA at 20:20, 19 September 2018

OCA — Wed, 19 Sep 2018 20:20:50 GMT

←Older revision		Revision as of 20:20, 19 September 2018
Line 3:		Line 3:
	<StructureSection load='6dzn' size='340' side='right' caption='[[6dzn]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6dzn' size='340' side='right' caption='[[6dzn]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dzn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DZN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dzn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DZN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AE3:2-(2-ETHOXYETHOXY)ETHANOL'>AE3</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AE3:2-(2-ETHOXYETHOXY)ETHANOL'>AE3</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dzn OCA], [http://pdbe.org/6dzn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dzn RCSB], [http://www.ebi.ac.uk/pdbsum/6dzn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dzn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dzn OCA], [http://pdbe.org/6dzn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dzn RCSB], [http://www.ebi.ac.uk/pdbsum/6dzn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dzn ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Monoclonal antibodies (mAbs) with pan-ebolavirus cross-reactivity are highly desirable, but development of such mAbs is limited by a lack of a molecular understanding of cross-reactive epitopes. The antibody ADI-15878 was previously identified from a human survivor of Ebola virus Makona variant (EBOV/Mak) infection. This mAb demonstrated potent neutralizing activity against all known ebolaviruses and provided protection in rodent and ferret models against three ebolavirus species. Here, we describe the unliganded crystal structure of ADI-15878 as well as the cryo-EM structures of ADI-15878 in complex with the EBOV/Mak and Bundibugyo virus (BDBV) glycoproteins (GPs). ADI-15878 binds through an induced-fit mechanism by targeting highly conserved residues in the internal fusion loop (IFL), bridging across GP protomers via the heptad repeat 1 (HR1) region. Our structures provide a more complete description of the ebolavirus immunogenic landscape, as well as a molecular basis for how rare but potent antibodies target conserved filoviral fusion machinery.
		+
		+	Structural Basis of Pan-Ebolavirus Neutralization by an Antibody Targeting the Glycoprotein Fusion Loop.,Murin CD, Bruhn JF, Bornholdt ZA, Copps J, Stanfield R, Ward AB Cell Rep. 2018 Sep 4;24(10):2723-2732.e4. doi: 10.1016/j.celrep.2018.08.009. PMID:30184505<ref>PMID:30184505</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6dzn" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Bruhn, J F]]		[[Category: Bruhn, J F]]
	[[Category: Murin, C D]]		[[Category: Murin, C D]]

OCA at 07:37, 12 September 2018

OCA — Wed, 12 Sep 2018 07:37:08 GMT

←Older revision		Revision as of 07:37, 12 September 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6dzn ~~is ON HOLD until Paper Publication~~	+	==Pan-ebolavirus human antibody ADI-15878 Fab==
-		+	<StructureSection load='6dzn' size='340' side='right' caption='[[6dzn]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~Authors~~: ~~Murin, C~~.D.~~, Ward, A~~.B.~~, Bruhn, J~~.F.~~, Stanfield, R~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6dzn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DZN FirstGlance]. <br>
-	~~Description~~: ~~Pan~~-~~ebolavirus human antibody ADI~~-~~15878 Fab~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AE3:2-(2-ETHOXYETHOXY)ETHANOL'>AE3</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dzn OCA], [http://pdbe.org/6dzn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dzn RCSB], [http://www.ebi.ac.uk/pdbsum/6dzn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dzn ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Ward~~, A.B]]	+	</table>
-	[[Category: Bruhn, J.F]]	+	__TOC__
-	[[Category: Murin, C.D]]	+	</StructureSection>
		+	[[Category: Bruhn, J F]]
		+	[[Category: Murin, C D]]
	[[Category: Stanfield, R]]		[[Category: Stanfield, R]]
		+	[[Category: Ward, A B]]
		+	[[Category: Adi-15878]]
		+	[[Category: Antibody]]
		+	[[Category: Bundibugyo virus]]
		+	[[Category: Ebola virus]]
		+	[[Category: Immune system]]
		+	[[Category: Immunotherapeutic]]
		+	[[Category: Pan-ebolavirus]]

OCA at 05:29, 18 July 2018

OCA — Wed, 18 Jul 2018 05:29:03 GMT

←Older revision		Revision as of 05:29, 18 July 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dzn is ON HOLD	+	The entry 6dzn is ON HOLD until Paper Publication

	Authors: Murin, C.D., Ward, A.B., Bruhn, J.F., Stanfield, R.		Authors: Murin, C.D., Ward, A.B., Bruhn, J.F., Stanfield, R.

-	Description: ~~Bundibugyo virus GP (mucin-deleted) in complex with pan~~-ebolavirus human antibody ADI-15878 Fab	+	Description: Pan-ebolavirus human antibody ADI-15878 Fab
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Ward, A.B]]		[[Category: Ward, A.B]]

OCA: Protected "6dzn" [edit=sysop:move=sysop]

OCA — Wed, 11 Jul 2018 04:11:05 GMT

Protected "6dzn" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:11, 11 July 2018

OCA: New page: '''Unreleased structure''' The entry 6dzn is ON HOLD Authors: Murin, C.D., Ward, A.B., Bruhn, J.F., Stanfield, R. Description: Bundibugyo virus GP (mucin-deleted) in complex with pan-e...

OCA — Wed, 11 Jul 2018 04:11:04 GMT

New page: '''Unreleased structure''' The entry 6dzn is ON HOLD Authors: Murin, C.D., Ward, A.B., Bruhn, J.F., Stanfield, R. Description: Bundibugyo virus GP (mucin-deleted) in complex with pan-e...

New page

'''Unreleased structure'''

The entry 6dzn is ON HOLD

Authors: Murin, C.D., Ward, A.B., Bruhn, J.F., Stanfield, R.

Description: Bundibugyo virus GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI-15878 Fab
[[Category: Unreleased Structures]]
[[Category: Ward, A.B]]
[[Category: Bruhn, J.F]]
[[Category: Murin, C.D]]
[[Category: Stanfield, R]]