6e0h - Revision history

OCA at 14:38, 13 March 2024

OCA — Wed, 13 Mar 2024 14:38:11 GMT

←Older revision		Revision as of 14:38, 13 March 2024
Line 3:		Line 3:
	<SX load='6e0h' size='340' side='right' viewer='molstar' caption='[[6e0h]], [[Resolution\|resolution]] 4.05Å' scene=''>		<SX load='6e0h' size='340' side='right' viewer='molstar' caption='[[6e0h]], [[Resolution\|resolution]] 4.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6e0h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Aspfu Aspfu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E0H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6e0h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus_Af293 Aspergillus fumigatus Af293]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E0H FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.05Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[6e1o\|6e1o]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">AFUA_4G02970 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=330879 ASPFU])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e0h OCA], [https://pdbe.org/6e0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e0h RCSB], [https://www.ebi.ac.uk/pdbsum/6e0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e0h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e0h OCA], [https://pdbe.org/6e0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e0h RCSB], [https://www.ebi.ac.uk/pdbsum/6e0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e0h ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/Q4WA18_ASPFU Q4WA18_ASPFU]
-	The lipid distribution of plasma membranes of eukaryotic cells is asymmetric and phospholipid scramblases disrupt this asymmetry by mediating the rapid, nonselective transport of lipids down their concentration gradients. As a result, phosphatidylserine is exposed to the outer leaflet of membrane, an important step in extracellular signaling networks controlling processes such as apoptosis, blood coagulation, membrane fusion and repair. Several TMEM16 family members have been identified as Ca(2+)-activated scramblases, but the mechanisms underlying their Ca(2+)-dependent gating and their effects on the surrounding lipid bilayer remain poorly understood. Here, we describe three high-resolution cryo-electron microscopy structures of a fungal scramblase from Aspergillus fumigatus, afTMEM16, reconstituted in lipid nanodiscs. These structures reveal that Ca(2+)-dependent activation of the scramblase entails global rearrangement of the transmembrane and cytosolic domains. These structures, together with functional experiments, suggest that activation of the protein thins the membrane near the transport pathway to facilitate rapid transbilayer lipid movement.	+
-		+
-	Structural basis of Ca(2+)-dependent activation and lipid transport by a TMEM16 scramblase.,Falzone ME, Rheinberger J, Lee BC, Peyear T, Sasset L, Raczkowski AM, Eng ET, Di Lorenzo A, Andersen OS, Nimigean CM, Accardi A Elife. 2019 Jan 16;8. pii: ~~43229. doi: 10.7554~~/~~eLife.43229. PMID:30648972<ref>PMID:30648972<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 6e0h" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: ~~Aspfu~~]]	+	[[Category: Aspergillus fumigatus Af293]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Accardi, A]]	+	[[Category: Accardi A]]
-	[[Category: Falzone~~, M E]]~~	+	[[Category: Falzone ME]]
-	~~[[Category: Ca2+-activated]]~~	+
-	~~[[Category: Lipid transport]]~~	+
-	~~[[Category: Membrane-reorganization]]~~	+
-	~~[[Category: Scramblase~~]]	+

OCA at 10:17, 18 March 2021

OCA — Thu, 18 Mar 2021 10:17:57 GMT

←Older revision		Revision as of 10:17, 18 March 2021
Line 3:		Line 3:
	<SX load='6e0h' size='340' side='right' viewer='molstar' caption='[[6e0h]], [[Resolution\|resolution]] 4.05Å' scene=''>		<SX load='6e0h' size='340' side='right' viewer='molstar' caption='[[6e0h]], [[Resolution\|resolution]] 4.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6e0h]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Aspfu Aspfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E0H OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6E0H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6e0h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspfu Aspfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E0H FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6e1o\|6e1o]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6e1o\|6e1o]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AFUA_4G02970 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=330879 ASPFU])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AFUA_4G02970 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=330879 ASPFU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6e0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e0h OCA], [~~http~~://pdbe.org/6e0h PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6e0h RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6e0h PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6e0h ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e0h OCA], [https://pdbe.org/6e0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e0h RCSB], [https://www.ebi.ac.uk/pdbsum/6e0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e0h ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:16, 11 April 2020

OCA — Sat, 11 Apr 2020 00:16:24 GMT

←Older revision		Revision as of 00:16, 11 April 2020
Line 3:		Line 3:
	<SX load='6e0h' size='340' side='right' viewer='molstar' caption='[[6e0h]], [[Resolution\|resolution]] 4.05Å' scene=''>		<SX load='6e0h' size='340' side='right' viewer='molstar' caption='[[6e0h]], [[Resolution\|resolution]] 4.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6e0h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfu Aspfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E0H OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6E0H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6e0h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfu Aspfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E0H OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6E0H FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6e1o\|6e1o]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6e1o\|6e1o]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AFUA_4G02970 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=330879 ASPFU])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AFUA_4G02970 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=330879 ASPFU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6e0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e0h OCA], [http://pdbe.org/6e0h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e0h RCSB], [http://www.ebi.ac.uk/pdbsum/6e0h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e0h ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6e0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e0h OCA], [http://pdbe.org/6e0h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e0h RCSB], [http://www.ebi.ac.uk/pdbsum/6e0h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e0h ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:59, 6 March 2020

OCA — Fri, 06 Mar 2020 20:59:34 GMT

←Older revision		Revision as of 20:59, 6 March 2020
Line 1:		Line 1:

	==PDB: afTMEM16 reconstituted in nanodiscs in the presence of Ca2+==		==PDB: afTMEM16 reconstituted in nanodiscs in the presence of Ca2+==
-	<~~StructureSection~~ load='6e0h' size='340' side='right'caption='[[6e0h]], [[Resolution\|resolution]] 4.05Å' scene=''>	+	<SX load='6e0h' size='340' side='right' viewer='molstar' caption='[[6e0h]], [[Resolution\|resolution]] 4.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6e0h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfu Aspfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E0H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E0H FirstGlance]. <br>		<table><tr><td colspan='2'>[[6e0h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfu Aspfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E0H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E0H FirstGlance]. <br>
Line 21:		Line 21:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Aspfu]]		[[Category: Aspfu]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 10:19, 18 December 2019

OCA — Wed, 18 Dec 2019 10:19:57 GMT

←Older revision		Revision as of 10:19, 18 December 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6e0h is ~~ON HOLD~~	+	==PDB: afTMEM16 reconstituted in nanodiscs in the presence of Ca2+==
		+	<StructureSection load='6e0h' size='340' side='right'caption='[[6e0h]], [[Resolution\|resolution]] 4.05Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6e0h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfu Aspfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E0H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E0H FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6e1o\|6e1o]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AFUA_4G02970 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=330879 ASPFU])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e0h OCA], [http://pdbe.org/6e0h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e0h RCSB], [http://www.ebi.ac.uk/pdbsum/6e0h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e0h ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The lipid distribution of plasma membranes of eukaryotic cells is asymmetric and phospholipid scramblases disrupt this asymmetry by mediating the rapid, nonselective transport of lipids down their concentration gradients. As a result, phosphatidylserine is exposed to the outer leaflet of membrane, an important step in extracellular signaling networks controlling processes such as apoptosis, blood coagulation, membrane fusion and repair. Several TMEM16 family members have been identified as Ca(2+)-activated scramblases, but the mechanisms underlying their Ca(2+)-dependent gating and their effects on the surrounding lipid bilayer remain poorly understood. Here, we describe three high-resolution cryo-electron microscopy structures of a fungal scramblase from Aspergillus fumigatus, afTMEM16, reconstituted in lipid nanodiscs. These structures reveal that Ca(2+)-dependent activation of the scramblase entails global rearrangement of the transmembrane and cytosolic domains. These structures, together with functional experiments, suggest that activation of the protein thins the membrane near the transport pathway to facilitate rapid transbilayer lipid movement.

-	~~Authors:~~ Falzone, ~~M.E.~~, ~~Accardi~~, A.	+	Structural basis of Ca(2+)-dependent activation and lipid transport by a TMEM16 scramblase.,Falzone ME, Rheinberger J, Lee BC, Peyear T, Sasset L, Raczkowski AM, Eng ET, Di Lorenzo A, Andersen OS, Nimigean CM, Accardi A Elife. 2019 Jan 16;8. pii: 43229. doi: 10.7554/eLife.43229. PMID:30648972<ref>PMID:30648972</ref>

-	~~Description: PDB: afTMEM16 reconstituted in nanodiscs in~~ the ~~presence~~ of ~~Ca2+~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6e0h" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Aspfu]]
		+	[[Category: Large Structures]]
	[[Category: Accardi, A]]		[[Category: Accardi, A]]
-	[[Category: Falzone, M.E]]	+	[[Category: Falzone, M E]]
		+	[[Category: Ca2+-activated]]
		+	[[Category: Lipid transport]]
		+	[[Category: Membrane-reorganization]]
		+	[[Category: Scramblase]]

OCA at 05:58, 30 January 2019

OCA — Wed, 30 Jan 2019 05:58:29 GMT

←Older revision		Revision as of 05:58, 30 January 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6e0h is ON HOLD ~~until Paper Publication~~	+	The entry 6e0h is ON HOLD

	Authors: Falzone, M.E., Accardi, A.		Authors: Falzone, M.E., Accardi, A.

OCA at 19:47, 9 August 2018

OCA — Thu, 09 Aug 2018 19:47:56 GMT

←Older revision		Revision as of 19:47, 9 August 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6e0h is ON HOLD	+	The entry 6e0h is ON HOLD until Paper Publication

	Authors: Falzone, M.E., Accardi, A.		Authors: Falzone, M.E., Accardi, A.

-	Description: afTMEM16 reconstituted in nanodiscs in the ~~absence~~ of Ca2+	+	Description: PDB: afTMEM16 reconstituted in nanodiscs in the presence of Ca2+
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Accardi, A]]		[[Category: Accardi, A]]
	[[Category: Falzone, M.E]]		[[Category: Falzone, M.E]]

OCA: Protected "6e0h" [edit=sysop:move=sysop]

OCA — Wed, 18 Jul 2018 05:32:20 GMT

Protected "6e0h" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:32, 18 July 2018

OCA: New page: '''Unreleased structure''' The entry 6e0h is ON HOLD Authors: Falzone, M.E., Accardi, A. Description: afTMEM16 reconstituted in nanodiscs in the absence of Ca2+ [[Category: Unreleased ...

OCA — Wed, 18 Jul 2018 05:32:18 GMT

New page: '''Unreleased structure''' The entry 6e0h is ON HOLD Authors: Falzone, M.E., Accardi, A. Description: afTMEM16 reconstituted in nanodiscs in the absence of Ca2+ [[Category: Unreleased ...

New page

'''Unreleased structure'''

The entry 6e0h is ON HOLD

Authors: Falzone, M.E., Accardi, A.

Description: afTMEM16 reconstituted in nanodiscs in the absence of Ca2+
[[Category: Unreleased Structures]]
[[Category: Accardi, A]]
[[Category: Falzone, M.E]]