6e5v - Revision history

OCA at 06:19, 11 October 2023

OCA — Wed, 11 Oct 2023 06:19:31 GMT

←Older revision		Revision as of 06:19, 11 October 2023
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	==human mGlu8 receptor amino terminal domain in complex with (S)-3,4-Dicarboxyphenylglycine (DCPG)==		==human mGlu8 receptor amino terminal domain in complex with (S)-3,4-Dicarboxyphenylglycine (DCPG)==
-	<StructureSection load='6e5v' size='340' side='right' caption='[[6e5v]], [[Resolution\|resolution]] 2.95Å' scene=''>	+	<StructureSection load='6e5v' size='340' side='right'caption='[[6e5v]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6e5v]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E5V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6E5V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6e5v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E5V FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HVG:4-[(S)-amino(carboxy)methyl]benzene-1,2-dicarboxylic+acid'>HVG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.95Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRM8, GPRC1H, MGLUR8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HVG:4-[(S)-amino(carboxy)methyl]benzene-1,2-dicarboxylic+acid'>HVG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6e5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e5v OCA], [~~http~~://pdbe.org/6e5v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6e5v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6e5v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6e5v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e5v OCA], [https://pdbe.org/6e5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e5v RCSB], [https://www.ebi.ac.uk/pdbsum/6e5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e5v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GRM8_HUMAN GRM8_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.<ref>PMID:9473604</ref>	+	[https://www.uniprot.org/uniprot/GRM8_HUMAN GRM8_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.<ref>PMID:9473604</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6e5v" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6e5v" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Metabotropic glutamate receptor 3D structures\|Metabotropic glutamate receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Ashok, S]]	+	[[Category: Large Structures]]
-	[[Category: Atwell, S]]	+	[[Category: Ashok S]]
-	[[Category: Bures, M]]	+	[[Category: Atwell S]]
-	[[Category: Chen, Q]]	+	[[Category: Bures M]]
-	[[Category: Hao, J]]	+	[[Category: Chen Q]]
-	[[Category: Ho~~, J D~~]]	+	[[Category: Hao J]]
-	[[Category: Monn~~, J A~~]]	+	[[Category: Ho JD]]
-	[[Category: Schkeryantz~~, J M~~]]	+	[[Category: Monn JA]]
-	[[Category: Vargas~~, M C~~]]	+	[[Category: Schkeryantz JM]]
-	[[Category: Wang, J]]	+	[[Category: Vargas MC]]
-	~~[[Category: Dcpg]]~~	+	[[Category: Wang J]]
-	~~[[Category: Grm8]]~~	+
-	~~[[Category: Mglur8 atd]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 07:04, 5 December 2018

OCA — Wed, 05 Dec 2018 07:04:14 GMT

←Older revision		Revision as of 07:04, 5 December 2018
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	<StructureSection load='6e5v' size='340' side='right' caption='[[6e5v]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='6e5v' size='340' side='right' caption='[[6e5v]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6e5v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E5V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6e5v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E5V FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HVG:4-[(S)-amino(carboxy)methyl]benzene-1,2-dicarboxylic+acid'>HVG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HVG:4-[(S)-amino(carboxy)methyl]benzene-1,2-dicarboxylic+acid'>HVG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRM8, GPRC1H, MGLUR8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e5v OCA], [http://pdbe.org/6e5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e5v RCSB], [http://www.ebi.ac.uk/pdbsum/6e5v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e5v ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e5v OCA], [http://pdbe.org/6e5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e5v RCSB], [http://www.ebi.ac.uk/pdbsum/6e5v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e5v ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Ashok, S]]		[[Category: Ashok, S]]
	[[Category: Atwell, S]]		[[Category: Atwell, S]]

OCA at 12:14, 7 November 2018

OCA — Wed, 07 Nov 2018 12:14:43 GMT

←Older revision		Revision as of 12:14, 7 November 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6e5v is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==human mGlu8 receptor amino terminal domain in complex with (S)-3,4-Dicarboxyphenylglycine (DCPG)==
		+	<StructureSection load='6e5v' size='340' side='right' caption='[[6e5v]], [[Resolution\|resolution]] 2.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6e5v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E5V FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HVG:4-[(S)-amino(carboxy)methyl]benzene-1,2-dicarboxylic+acid'>HVG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e5v OCA], [http://pdbe.org/6e5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e5v RCSB], [http://www.ebi.ac.uk/pdbsum/6e5v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e5v ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRM8_HUMAN GRM8_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.<ref>PMID:9473604</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	(S)-3,4-dicarboxyphenylglycine (DCPG) was first reported in 2001 as a potent orthosteric agonist with high subtype selectivity for the mGlu8 receptor, but the structural basis for its high selectivity is not well understood. We have solved a co-crystal structure of recombinant human mGlu8 amino terminal domain (ATD) protein bound to (S)-DCPG, which possesses the largest lobe opening angle observed to date among known agonist-bound mGlu ATD crystal structures. The binding conformation of (S)-DCPG observed in the crystal structure is significantly different from that in the homology model built from an L-Glutamate-bound rat mGlu1 ATD crystal structure, which has a smaller lobe opening angle. This highlights the importance of considering various lobe opening angles when modeling mGlu ATD-ligand complex. New homology models of other mGlu receptors based on the (S)-DCPG-bound mGlu8 ATD crystal structure were explored to rationalize (S)-DCPG's high mGlu8 receptor subtype selectivity.

-	~~Authors: Chen~~, Q., Ho~~, J.D.~~, Ashok, S., Vargas~~, M.C.~~, Wang, J., Atwell, S., Bures, M., Schkeryantz~~, J.M.~~, Monn, J.A.~~, Hao, J~~.	+	Structural Basis for (S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8 Receptor.,Chen Q, Ho JD, Ashok S, Vargas MC, Wang J, Atwell S, Bures M, Schkeryantz JM, Monn JA, Hao J J Med Chem. 2018 Oct 26. doi: 10.1021/acs.jmedchem.8b01120. PMID:30365309<ref>PMID:30365309</ref>

-	~~Description: human mGlu8 receptor amino terminal domain in complex with (~~S)-~~3,4~~-~~Dicarboxyphenylglycine (DCPG)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	~~[[Category: Hao, J]]~~	+	<div class="pdbe-citations 6e5v" style="background-color:#fffaf0;"></div>
-	~~[[Category: Bures, M]]~~	+	== References ==
-	~~[[Category: Monn, J.A]]~~	+	<references/>
-	~~[[Category: Vargas, M.C]]~~	+	__TOC__
		+	</StructureSection>
	[[Category: Ashok, S]]		[[Category: Ashok, S]]
-	[[Category: Schkeryantz, J.M]]
	[[Category: Atwell, S]]		[[Category: Atwell, S]]
		+	[[Category: Bures, M]]
	[[Category: Chen, Q]]		[[Category: Chen, Q]]
-	[[Category: Ho, J.D]]	+	[[Category: Hao, J]]
		+	[[Category: Ho, J D]]
		+	[[Category: Monn, J A]]
		+	[[Category: Schkeryantz, J M]]
		+	[[Category: Vargas, M C]]
	[[Category: Wang, J]]		[[Category: Wang, J]]
		+	[[Category: Dcpg]]
		+	[[Category: Grm8]]
		+	[[Category: Mglur8 atd]]
		+	[[Category: Signaling protein]]

OCA at 04:38, 22 August 2018

OCA — Wed, 22 Aug 2018 04:38:44 GMT

←Older revision		Revision as of 04:38, 22 August 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6e5v is ON HOLD	+	The entry 6e5v is ON HOLD until Paper Publication

	Authors: Chen, Q., Ho, J.D., Ashok, S., Vargas, M.C., Wang, J., Atwell, S., Bures, M., Schkeryantz, J.M., Monn, J.A., Hao, J.		Authors: Chen, Q., Ho, J.D., Ashok, S., Vargas, M.C., Wang, J., Atwell, S., Bures, M., Schkeryantz, J.M., Monn, J.A., Hao, J.
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Hao, J]]		[[Category: Hao, J]]
-	[[Category: Monn, J.A]]
-	[[Category: Ashok, S]]
-	[[Category: Atwell, S]]
	[[Category: Bures, M]]		[[Category: Bures, M]]
		+	[[Category: Monn, J.A]]
	[[Category: Vargas, M.C]]		[[Category: Vargas, M.C]]
		+	[[Category: Ashok, S]]
	[[Category: Schkeryantz, J.M]]		[[Category: Schkeryantz, J.M]]
		+	[[Category: Atwell, S]]
	[[Category: Chen, Q]]		[[Category: Chen, Q]]
	[[Category: Ho, J.D]]		[[Category: Ho, J.D]]
	[[Category: Wang, J]]		[[Category: Wang, J]]

OCA: Protected "6e5v" [edit=sysop:move=sysop]

OCA — Wed, 01 Aug 2018 17:04:49 GMT

Protected "6e5v" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:04, 1 August 2018

OCA: New page: '''Unreleased structure''' The entry 6e5v is ON HOLD Authors: Chen, Q., Ho, J.D., Ashok, S., Vargas, M.C., Wang, J., Atwell, S., Bures, M., Schkeryantz, J.M., Monn, J.A., Hao, J. Descr...

OCA — Wed, 01 Aug 2018 17:04:48 GMT

New page: '''Unreleased structure''' The entry 6e5v is ON HOLD Authors: Chen, Q., Ho, J.D., Ashok, S., Vargas, M.C., Wang, J., Atwell, S., Bures, M., Schkeryantz, J.M., Monn, J.A., Hao, J. Descr...

New page

'''Unreleased structure'''

The entry 6e5v is ON HOLD

Authors: Chen, Q., Ho, J.D., Ashok, S., Vargas, M.C., Wang, J., Atwell, S., Bures, M., Schkeryantz, J.M., Monn, J.A., Hao, J.

Description: human mGlu8 receptor amino terminal domain in complex with (S)-3,4-Dicarboxyphenylglycine (DCPG)
[[Category: Unreleased Structures]]
[[Category: Hao, J]]
[[Category: Monn, J.A]]
[[Category: Ashok, S]]
[[Category: Atwell, S]]
[[Category: Bures, M]]
[[Category: Vargas, M.C]]
[[Category: Schkeryantz, J.M]]
[[Category: Chen, Q]]
[[Category: Ho, J.D]]
[[Category: Wang, J]]