6e73 - Revision history

OCA at 14:39, 13 March 2024

OCA — Wed, 13 Mar 2024 14:39:40 GMT

←Older revision

Revision as of 14:39, 13 March 2024

OCA at 10:27, 18 December 2019

OCA — Wed, 18 Dec 2019 10:27:22 GMT

←Older revision		Revision as of 10:27, 18 December 2019
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	<StructureSection load='6e73' size='340' side='right'caption='[[6e73]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='6e73' size='340' side='right'caption='[[6e73]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6e73]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E73 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E73 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6e73]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E73 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E73 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1FL:5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC+ACID'>1FL</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1FL:5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC+ACID'>1FL</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TTR, PALB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e73 OCA], [http://pdbe.org/6e73 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e73 RCSB], [http://www.ebi.ac.uk/pdbsum/6e73 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e73 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e73 OCA], [http://pdbe.org/6e73 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e73 RCSB], [http://www.ebi.ac.uk/pdbsum/6e73 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e73 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cascio, D]]		[[Category: Cascio, D]]

OCA at 06:11, 31 July 2019

OCA — Wed, 31 Jul 2019 06:11:39 GMT

←Older revision		Revision as of 06:11, 31 July 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6e73 is ~~ON HOLD until Paper Publication~~	+	==Structure of Human Transthyretin Val30Met Mutant in Complex with Diflunisal==
-		+	<StructureSection load='6e73' size='340' side='right'caption='[[6e73]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~: ~~Chung~~, K., ~~Saelices~~, L., ~~Sawaya~~, M.R., ~~Cascio~~, D., ~~Eisenberg~~, D.S.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6e73]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E73 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E73 FirstGlance]. <br>
-	~~Description~~: ~~Structure~~ of ~~Human Transthyretin Val30Met Mutant~~ in ~~Complex with Diflunisal~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1FL:5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC+ACID'>1FL</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e73 OCA], [http://pdbe.org/6e73 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e73 RCSB], [http://www.ebi.ac.uk/pdbsum/6e73 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e73 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Eisenberg, D~~.S]]	+	</table>
-	[[Category: ~~Saelices, L~~]]	+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN]] Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR) [MIM:[http://omim.org/entry/105210 105210]]. A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor.<ref>PMID:11243784</ref> <ref>PMID:15735344</ref> <ref>PMID:19167329</ref> <ref>PMID:3818577</ref> <ref>PMID:3022108</ref> <ref>PMID:6651852</ref> <ref>PMID:6583672</ref> <ref>PMID:3135807</ref> <ref>PMID:1517749</ref> <ref>PMID:1932142</ref> <ref>PMID:7923855</ref> <ref>PMID:8382610</ref> <ref>PMID:8428915</ref> <ref>PMID:9733771</ref> <ref>PMID:12403615</ref> <ref>PMID:16185074</ref> <ref>PMID:16627944</ref> <ref>PMID:6487335</ref> <ref>PMID:3722385</ref> <ref>PMID:2891727</ref> <ref>PMID:2161654</ref> <ref>PMID:2363717</ref> <ref>PMID:1656975</ref> <ref>PMID:2046936</ref> <ref>PMID:1570831</ref> <ref>PMID:1734866</ref> <ref>PMID:1520326</ref> <ref>PMID:1520336</ref> <ref>PMID:1544214</ref> <ref>PMID:1351039</ref> <ref>PMID:1301926</ref> <ref>PMID:1362222</ref> <ref>PMID:1436517</ref> <ref>PMID:8352764</ref> <ref>PMID:8038017</ref> <ref>PMID:8257997</ref> <ref>PMID:8095302</ref> <ref>PMID:1997217</ref> <ref>PMID:8019560</ref> <ref>PMID:8081397</ref> <ref>PMID:7914929</ref> <ref>PMID:8133316</ref> <ref>PMID:7910950</ref> <ref>PMID:7655883</ref> <ref>PMID:7850982</ref> <ref>PMID:8579098</ref> <ref>PMID:9066351</ref> <ref>PMID:8990019</ref> <ref>PMID:9605286</ref> <ref>PMID:10036587</ref> <ref>PMID:10627135</ref> <ref>PMID:10694917</ref> <ref>PMID:10211412</ref> <ref>PMID:10439117</ref> <ref>PMID:10611950</ref> <ref>PMID:10071047</ref> <ref>PMID:10436378</ref> <ref>PMID:10842705</ref> <ref>PMID:10842718</ref> <ref>PMID:10882995</ref> <ref>PMID:11445644</ref> <ref>PMID:12557757</ref> <ref>PMID:11866053</ref> <ref>PMID:12050338</ref> <ref>PMID:12771253</ref> <ref>PMID:15214015</ref> <ref>PMID:15478468</ref> <ref>PMID:15217993</ref> <ref>PMID:17453626</ref> <ref>PMID:17577687</ref> <ref>PMID:17503405</ref> <ref>PMID:17635579</ref> Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) [MIM:[http://omim.org/entry/145680 145680]]. It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities.<ref>PMID:1979335</ref> Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1) [MIM:[http://omim.org/entry/115430 115430]]. It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.<ref>PMID:8309582</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN]] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:3714052</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Cascio, D]]		[[Category: Cascio, D]]
-	[[Category: Sawaya, M.R]]
	[[Category: Chung, K]]		[[Category: Chung, K]]
		+	[[Category: Eisenberg, D S]]
		+	[[Category: Saelices, L]]
		+	[[Category: Sawaya, M R]]
		+	[[Category: Amyloid]]
		+	[[Category: Diflunisal]]
		+	[[Category: Human transthyretin]]
		+	[[Category: Protein binding]]
		+	[[Category: Transthyretin]]

OCA at 04:39, 22 August 2018

OCA — Wed, 22 Aug 2018 04:39:34 GMT

←Older revision		Revision as of 04:39, 22 August 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6e73 is ON HOLD	+	The entry 6e73 is ON HOLD until Paper Publication

	Authors: Chung, K., Saelices, L., Sawaya, M.R., Cascio, D., Eisenberg, D.S.		Authors: Chung, K., Saelices, L., Sawaya, M.R., Cascio, D., Eisenberg, D.S.
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	Description: Structure of Human Transthyretin Val30Met Mutant in Complex with Diflunisal		Description: Structure of Human Transthyretin Val30Met Mutant in Complex with Diflunisal
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Sawaya, M.R]]
-	[[Category: Chung, K]]
	[[Category: Eisenberg, D.S]]		[[Category: Eisenberg, D.S]]
	[[Category: Saelices, L]]		[[Category: Saelices, L]]
	[[Category: Cascio, D]]		[[Category: Cascio, D]]
		+	[[Category: Sawaya, M.R]]
		+	[[Category: Chung, K]]

OCA: Protected "6e73" [edit=sysop:move=sysop]

OCA — Wed, 01 Aug 2018 17:07:58 GMT

Protected "6e73" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:07, 1 August 2018

OCA: New page: '''Unreleased structure''' The entry 6e73 is ON HOLD Authors: Chung, K., Saelices, L., Sawaya, M.R., Cascio, D., Eisenberg, D.S. Description: Structure of Human Transthyretin Val30Met ...

OCA — Wed, 01 Aug 2018 17:07:57 GMT

New page: '''Unreleased structure''' The entry 6e73 is ON HOLD Authors: Chung, K., Saelices, L., Sawaya, M.R., Cascio, D., Eisenberg, D.S. Description: Structure of Human Transthyretin Val30Met ...

New page

'''Unreleased structure'''

The entry 6e73 is ON HOLD

Authors: Chung, K., Saelices, L., Sawaya, M.R., Cascio, D., Eisenberg, D.S.

Description: Structure of Human Transthyretin Val30Met Mutant in Complex with Diflunisal
[[Category: Unreleased Structures]]
[[Category: Sawaya, M.R]]
[[Category: Chung, K]]
[[Category: Eisenberg, D.S]]
[[Category: Saelices, L]]
[[Category: Cascio, D]]