6egt - Revision history

OCA at 06:09, 12 June 2019

OCA — Wed, 12 Jun 2019 06:09:54 GMT

←Older revision		Revision as of 06:09, 12 June 2019
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	==Structure of RVFV envelope protein Gc in postfusion conformation in complex with MES==		==Structure of RVFV envelope protein Gc in postfusion conformation in complex with MES==
-	<StructureSection load='6egt' size='340' side='right' caption='[[6egt]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='6egt' size='340' side='right'caption='[[6egt]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6egt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rvfv Rvfv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EGT FirstGlance]. <br>		<table><tr><td colspan='2'>[[6egt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rvfv Rvfv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EGT FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Rvfv]]		[[Category: Rvfv]]
-	[[Category: ~~GUARDADO~~-~~CALVO~~, P]]	+	[[Category: Guardado-Calvo, P]]
-	[[Category: ~~REY~~, F A]]	+	[[Category: Rey, F A]]
	[[Category: Fusion protein viral envelope lipid interaction viral fusion]]		[[Category: Fusion protein viral envelope lipid interaction viral fusion]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 10:19, 15 November 2017

OCA — Wed, 15 Nov 2017 10:19:03 GMT

←Older revision		Revision as of 10:19, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='6egt' size='340' side='right' caption='[[6egt]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6egt' size='340' side='right' caption='[[6egt]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6egt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EGT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6egt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rvfv Rvfv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EGT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6egt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6egt OCA], [http://pdbe.org/6egt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6egt RCSB], [http://www.ebi.ac.uk/pdbsum/6egt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6egt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6egt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6egt OCA], [http://pdbe.org/6egt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6egt RCSB], [http://www.ebi.ac.uk/pdbsum/6egt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6egt ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Rift Valley fever virus (RVFV) is transmitted by infected mosquitoes, causing severe disease in humans and livestock across Africa. We determined the x-ray structure of the RVFV class II fusion protein Gc in its postfusion form and in complex with a glycerophospholipid (GPL) bound in a conserved cavity next to the fusion loop. Site-directed mutagenesis and molecular dynamics simulations further revealed a built-in motif allowing en bloc insertion of the fusion loop into membranes, making few nonpolar side-chain interactions with the aliphatic moiety and multiple polar interactions with lipid head groups upon membrane restructuring. The GPL head-group recognition pocket is conserved in the fusion proteins of other arthropod-borne viruses, such as Zika and chikungunya viruses, which have recently caused major epidemics worldwide.
		+
		+	A glycerophospholipid-specific pocket in the RVFV class II fusion protein drives target membrane insertion.,Guardado-Calvo P, Atkovska K, Jeffers SA, Grau N, Backovic M, Perez-Vargas J, de Boer SM, Tortorici MA, Pehau-Arnaudet G, Lepault J, England P, Rottier PJ, Bosch BJ, Hub JS, Rey FA Science. 2017 Nov 3;358(6363):663-667. doi: 10.1126/science.aal2712. PMID:29097548<ref>PMID:29097548</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6egt" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Rvfv]]
	[[Category: GUARDADO-CALVO, P]]		[[Category: GUARDADO-CALVO, P]]
	[[Category: REY, F A]]		[[Category: REY, F A]]
	[[Category: Fusion protein viral envelope lipid interaction viral fusion]]		[[Category: Fusion protein viral envelope lipid interaction viral fusion]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 06:34, 1 November 2017

OCA — Wed, 01 Nov 2017 06:34:44 GMT

←Older revision		Revision as of 06:34, 1 November 2017
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-	'''Unreleased structure'''

-	~~The entry 6egt is ON HOLD until Sep 12 2019~~	+	==Structure of RVFV envelope protein Gc in postfusion conformation in complex with MES==
-		+	<StructureSection load='6egt' size='340' side='right' caption='[[6egt]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~Authors: GUARDADO-CALVO, P., REY, F.A.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6egt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EGT FirstGlance]. <br>
-	~~Description:~~ Structure of RVFV envelope protein Gc in postfusion conformation in complex with MES	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6egt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6egt OCA], [http://pdbe.org/6egt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6egt RCSB], [http://www.ebi.ac.uk/pdbsum/6egt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6egt ProSAT]</span></td></tr>
-	[[Category: ~~Guardado~~-~~Calvo~~, P]]	+	</table>
-	[[Category: ~~Rey~~, F.A]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: GUARDADO-CALVO, P]]
		+	[[Category: REY, F A]]
		+	[[Category: Fusion protein viral envelope lipid interaction viral fusion]]
		+	[[Category: Viral protein]]

OCA: Protected "6egt" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 17:08:57 GMT

Protected "6egt" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:08, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 6egt is ON HOLD until Sep 12 2019 Authors: GUARDADO-CALVO, P., REY, F.A. Description: Structure of RVFV envelope protein Gc in postfusion conformat...

OCA — Wed, 27 Sep 2017 17:08:56 GMT

New page: '''Unreleased structure''' The entry 6egt is ON HOLD until Sep 12 2019 Authors: GUARDADO-CALVO, P., REY, F.A. Description: Structure of RVFV envelope protein Gc in postfusion conformat...

New page

'''Unreleased structure'''

The entry 6egt is ON HOLD until Sep 12 2019

Authors: GUARDADO-CALVO, P., REY, F.A.

Description: Structure of RVFV envelope protein Gc in postfusion conformation in complex with MES
[[Category: Unreleased Structures]]
[[Category: Guardado-Calvo, P]]
[[Category: Rey, F.A]]