6eh9 - Revision history

OCA at 09:10, 11 November 2020

OCA — Wed, 11 Nov 2020 09:10:39 GMT

←Older revision		Revision as of 09:10, 11 November 2020
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	==HA1.7 Human T-Cell Receptor specific for Influenza virus epitope PKYVKQNTLKLAT presented by Human Leukocyte Antigen HLA-DR0101==		==HA1.7 Human T-Cell Receptor specific for Influenza virus epitope PKYVKQNTLKLAT presented by Human Leukocyte Antigen HLA-DR0101==
-	<StructureSection load='6eh9' size='340' side='right' caption='[[6eh9]], [[Resolution\|resolution]] 2.49Å' scene=''>	+	<StructureSection load='6eh9' size='340' side='right'caption='[[6eh9]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6eh9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EH9 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6EH9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6eh9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EH9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6EH9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6eh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eh9 OCA], [http://pdbe.org/6eh9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eh9 RCSB], [http://www.ebi.ac.uk/pdbsum/6eh9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eh9 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6eh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eh9 OCA], [http://pdbe.org/6eh9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eh9 RCSB], [http://www.ebi.ac.uk/pdbsum/6eh9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eh9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 6eh9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6eh9" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[T-cell receptor 3D structures\|T-cell receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Cole, D K]]		[[Category: Cole, D K]]
	[[Category: Rizkallah, P J]]		[[Category: Rizkallah, P J]]

OCA at 06:33, 9 May 2018

OCA — Wed, 09 May 2018 06:33:56 GMT

←Older revision		Revision as of 06:33, 9 May 2018
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	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eh9 OCA], [http://pdbe.org/6eh9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eh9 RCSB], [http://www.ebi.ac.uk/pdbsum/6eh9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eh9 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eh9 OCA], [http://pdbe.org/6eh9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eh9 RCSB], [http://www.ebi.ac.uk/pdbsum/6eh9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eh9 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	T-cell immunity is controlled by T cell receptor (TCR) binding to peptide major histocompatibility complexes (pMHCs). The nature of the interaction between these two proteins has been the subject of many investigations because of its central role in immunity against pathogens, cancer, in autoimmunity, and during organ transplant rejection. Crystal structures comparing unbound and pMHC-bound TCRs have revealed flexibility at the interaction interface, particularly from the perspective of the TCR. However, crystal structures represent only a snapshot of protein conformation that could be influenced through biologically irrelevant crystal lattice contacts and other factors. Here, we solved the structures of three unbound TCRs from multiple crystals. Superposition of identical TCR structures from different crystals revealed some conformation differences of up to 5 A in individual complementarity determining region (CDR) loops that are similar to those that have previously been attributed to antigen engagement. We then used a combination of rigidity analysis and simulations of protein motion to reveal the theoretical potential of TCR CDR loop flexibility in unbound state. These simulations of protein motion support the notion that crystal structures may only offer an artifactual indication of TCR flexibility, influenced by crystallization conditions and crystal packing that is inconsistent with the theoretical potential of intrinsic TCR motions.
		+
		+	In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.,Holland CJ, MacLachlan BJ, Bianchi V, Hesketh SJ, Morgan R, Vickery O, Bulek AM, Fuller A, Godkin A, Sewell AK, Rizkallah PJ, Wells S, Cole DK Front Immunol. 2018 Apr 11;9:674. doi: 10.3389/fimmu.2018.00674. eCollection, 2018. PMID:29696015<ref>PMID:29696015</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6eh9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 05:48, 18 April 2018

OCA — Wed, 18 Apr 2018 05:48:06 GMT

←Older revision		Revision as of 05:48, 18 April 2018
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-	'''Unreleased structure'''

-	~~The entry 6eh9 is ON HOLD until Paper Publication~~	+	==HA1.7 Human T-Cell Receptor specific for Influenza virus epitope PKYVKQNTLKLAT presented by Human Leukocyte Antigen HLA-DR0101==
-		+	<StructureSection load='6eh9' size='340' side='right' caption='[[6eh9]], [[Resolution\|resolution]] 2.49Å' scene=''>
-	~~Authors: Rizkallah, P.J., Cole, D.K.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6eh9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EH9 FirstGlance]. <br>
-	~~Description:~~ HA1.7 Human T-Cell Receptor specific for Influenza virus epitope PKYVKQNTLKLAT presented by Human Leukocyte Antigen HLA-DR0101	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eh9 OCA], [http://pdbe.org/6eh9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eh9 RCSB], [http://www.ebi.ac.uk/pdbsum/6eh9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eh9 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: Cole, D.K]]	+	__TOC__
-	[[Category: Rizkallah, P.J]]	+	</StructureSection>
		+	[[Category: Cole, D K]]
		+	[[Category: Rizkallah, P J]]
		+	[[Category: 3d structure]]
		+	[[Category: Human leukocute antigen]]
		+	[[Category: Human t cell receptor]]
		+	[[Category: Immune system]]
		+	[[Category: Influenza haemagglutinin epitope]]

OCA: Protected "6eh9" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 17:09:44 GMT

Protected "6eh9" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:09, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 6eh9 is ON HOLD until Paper Publication Authors: Rizkallah, P.J., Cole, D.K. Description: HA1.7 Human T-Cell Receptor specific for Influenza virus ...

OCA — Wed, 27 Sep 2017 17:09:42 GMT

New page: '''Unreleased structure''' The entry 6eh9 is ON HOLD until Paper Publication Authors: Rizkallah, P.J., Cole, D.K. Description: HA1.7 Human T-Cell Receptor specific for Influenza virus ...

New page

'''Unreleased structure'''

The entry 6eh9 is ON HOLD until Paper Publication

Authors: Rizkallah, P.J., Cole, D.K.

Description: HA1.7 Human T-Cell Receptor specific for Influenza virus epitope PKYVKQNTLKLAT presented by Human Leukocyte Antigen HLA-DR0101
[[Category: Unreleased Structures]]
[[Category: Cole, D.K]]
[[Category: Rizkallah, P.J]]