6eix - Revision history

6eix - Revision history http://52.214.119.220/wiki/index.php?title=6eix&action=history Revision history for this page on the wiki en MediaWiki 1.11.2 Tue, 14 Apr 2026 21:46:02 GMT OCA at 07:39, 13 December 2017 http://52.214.119.220/wiki/index.php?title=6eix&diff=2833109&oldid=prev <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 07:39, 13 December 2017</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 24:</td> <td colspan="2" class="diff-lineno">Line 24:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Bullock, A N]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Bullock, A N]]</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Canning, P]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Canning, P]]</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Delft, F <del style="color: red; font-weight: bold; text-decoration: none;">Von</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Delft, F <ins style="color: red; font-weight: bold; text-decoration: none;">von</ins>]]</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Edwards, A M]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Edwards, A M]]</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Krojer, T]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Krojer, T]]</div></td></tr> </table> Wed, 13 Dec 2017 07:39:13 GMT OCA http://52.214.119.220/wiki/index.php/Talk:6eix OCA: Protected "6eix" [edit=sysop:move=sysop] http://52.214.119.220/wiki/index.php?title=6eix&diff=2802834&oldid=prev <p>Protected "<a href="/wiki/index.php/6eix" title="6eix">6eix</a>" [edit=sysop:move=sysop]</p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 11:51, 6 November 2017</td> </tr> </table> Mon, 06 Nov 2017 11:51:05 GMT OCA http://52.214.119.220/wiki/index.php/Talk:6eix OCA: New page: ==Crystal structure of the kinase domain of the Q207E mutant of ACVR1 (ALK2) in complex with a 2-aminopyridine inhibitor K02288== <StructureSection load='6eix' size='340' side='right' cap... http://52.214.119.220/wiki/index.php?title=6eix&diff=2802833&oldid=prev <p>New page: ==Crystal structure of the kinase domain of the Q207E mutant of ACVR1 (ALK2) in complex with a 2-aminopyridine inhibitor K02288== <StructureSection load='6eix' size='340' side='right' cap...</p> <p><b>New page</b></p><div><br /> ==Crystal structure of the kinase domain of the Q207E mutant of ACVR1 (ALK2) in complex with a 2-aminopyridine inhibitor K02288==<br /> <StructureSection load='6eix' size='340' side='right' caption='[[6eix]], [[Resolution|resolution]] 2.30&Aring;' scene=''><br /> == Structural highlights ==<br /> <table><tr><td colspan='2'>[[6eix]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EIX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EIX FirstGlance]. <br><br /> </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3F:3-[6-AMINO-5-(3,4,5-TRIMETHOXYPHENYL)PYRIDIN-3-YL]PHENOL'>A3F</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr><br /> <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACVR1, ACVRLK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr><br /> <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein_serine/threonine_kinase Receptor protein serine/threonine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.30 2.7.11.30] </span></td></tr><br /> <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eix OCA], [http://pdbe.org/6eix PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eix RCSB], [http://www.ebi.ac.uk/pdbsum/6eix PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eix ProSAT]</span></td></tr><br /> </table><br /> == Disease ==<br /> [[http://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN]] Fibrodysplasia ossificans progressiva. Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:[http://omim.org/entry/135100 135100]]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.<ref>PMID:16642017</ref> <ref>PMID:19085907</ref> <ref>PMID:19330033</ref> <br /> == Function ==<br /> [[http://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN]] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity). <br /> == References ==<br /> <references/><br /> __TOC__<br /> </StructureSection><br /> [[Category: Human]]<br /> [[Category: Receptor protein serine/threonine kinase]]<br /> [[Category: Allerston, C K]]<br /> [[Category: Arrowsmith, C H]]<br /> [[Category: Bountra, C]]<br /> [[Category: Bullock, A N]]<br /> [[Category: Canning, P]]<br /> [[Category: Delft, F Von]]<br /> [[Category: Edwards, A M]]<br /> [[Category: Krojer, T]]<br /> [[Category: Sanvitale, C E]]<br /> [[Category: Williams, E P]]<br /> [[Category: Alk2]]<br /> [[Category: Bmp]]<br /> [[Category: Kinase]]<br /> [[Category: Receptor]]<br /> [[Category: Sgc]]<br /> [[Category: Signaling protein]]<br /> [[Category: Structural genomic]]</div> Mon, 06 Nov 2017 11:51:03 GMT OCA http://52.214.119.220/wiki/index.php/Talk:6eix